Oxidative Stress and NADPH Oxidase: Connecting Electromagnetic Fields, Cation Channels and Biological Effects

Georgiou, Christos D.; Margaritis, Lukas H.

doi:10.3390/ijms221810041

Cited by 19 publications

(9 citation statements)

References 86 publications

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“…In accordance with the tenor of the present review article, several authors have proposed voltage-gated (dependent) ion channels as molecular transducers of weak external EMF fields into biological signals (e.g., Pall, 2013Pall, , 2015Pall, , 2016Li et al, 2020a;Georgiou and Margaritis, 2021;Panagopoulos et al, 2021;Wust et al, 2021). Identification of voltage-gated ion channels as central functional units in electrolocation of fishes (see section 4 "Biological voltmeters" of this article) may further support this "ion channel hypothesis" of external EMF perception.…”

Section: Discussionsupporting

confidence: 82%

Ion channels as molecular targets of glioblastoma electrotherapy

Abed

Ganser

Eckert

et al. 2023

Front. Cell. Neurosci.

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Therapies with weak, non-ionizing electromagnetic fields comprise FDA-approved treatments such as Tumor Treating Fields (TTFields) that are used for adjuvant therapy of glioblastoma. In vitro data and animal models suggest a variety of biological TTFields effects. In particular, effects ranging from direct tumoricidal, radio- or chemotherapy-sensitizing, metastatic spread-inhibiting, up to immunostimulation have been described. Diverse underlying molecular mechanisms, such as dielectrophoresis of cellular compounds during cytokinesis, disturbing the formation of the spindle apparatus during mitosis, and perforating the plasma membrane have been proposed. Little attention, however, has been paid to molecular structures that are predestinated to percept electromagnetic fields—the voltage sensors of voltage-gated ion channels. The present review article briefly summarizes the mode of action of voltage sensing by ion channels. Moreover, it introduces into the perception of ultra-weak electric fields by specific organs of fishes with voltage-gated ion channels as key functional units therein. Finally, this article provides an overview of the published data on modulation of ion channel function by diverse external electromagnetic field protocols. Combined, these data strongly point to a function of voltage-gated ion channels as transducers between electricity and biology and, hence, to voltage-gated ion channels as primary targets of electrotherapy.

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Section: Discussionsupporting

confidence: 82%

Ion channels as molecular targets of glioblastoma electrotherapy

Abed

Ganser

Eckert

et al. 2023

Front. Cell. Neurosci.

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“…Studies have shown that NADPH Oxidases (NOXs) can promote ROS accumulation in cells and exacerbate inflammatory responses in certain mammalian cells, by promoting the activation of inflammatory pathways and the production of inflammatory factors [ 31 , 32 ]. Antioxidant enzymes, including SOD, SOD2, and peroxidases such as GPX and CAT, play a crucial role in antioxidant defense by regulating ROS levels [ 33 , 34 ].…”

Section: Discussionmentioning

confidence: 99%

Cecropin A Alleviates LPS-Induced Oxidative Stress and Apoptosis of Bovine Endometrial Epithelial Cells

Zhao,

Zhang,

Sun

et al. 2024

Animals

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Dairy cows receiving a prolonged high-concentrate diet express an elevated concentration of lipopolysaccharides (LPSs) in the peripheral blood circulation, accompanied by a series of systemic inflammatory responses; however, the specific impacts of inflammation are yet to be determined. Cecropin-like antimicrobial peptides have become a research hotspot regarding antimicrobial peptides because of their excellent anti-inflammatory activities, and cecropin A is a major member of the cecropin family. To elucidate the mechanism of cecropin A as anti-inflammatory under the condition of sub-acute ruminal acidosis (SARA) in dairy cows, we induced inflammation in bEECs with LPS (10 µg/mL) and then added cecropin A (25 µM). Afterwards, we detected three categories of indexes including oxidative stress indices, inflammation-related genes, and apoptosis-related genes in bovine endometrial epithelial cells (bEECs). The results indicated that cecropin A has the ability to reduce inflammatory factors TNF-α, IL-1β, and IL-8 and inhibit the MAPK pathway to alleviate inflammation. In addition, cecropin A is able to reduce reactive oxygen species (ROS) levels and alleviates LPS-induced oxidative stress and mitochondrial dysfunction by downregulating NADPH Oxidase (NOX), and upregulating catalase (CAT), glutathione peroxidase (GPX), and superoxide dismutase (SOD). Furthermore, cecropin A demonstrates the ability to inhibit apoptosis by suppressing the mitochondrial-dependent apoptotic pathway, specifically Fas/FasL-caspase-8/-3. The observed increase in the Bcl-2/Bax ratio, a known apoptosis regulator, further supports this finding. In conclusion, our study presents novel solutions for addressing inflammatory responses associated with SARA.

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“…In addition to the mitochondrial electron transport chain, ROS can also be generated through the catalytic reaction of NADPH oxidase (NOX) [ 20 ]. NOX plays a crucial role in the production of ROS by reducing O 2 to H 2 O 2 through the donation of a second electron to O 2 · − [ 1 , 21 ]. H 2 O 2 , serving as a messenger molecule, assumes a pivotal role in redox sensing, signaling, and redox regulation, with its production primarily stemming from the breakdown of O 2 through a swift and efficient reaction [ 22 ].…”

Section: Os and Rosmentioning

confidence: 99%

Targeting oxidative stress as a preventive and therapeutic approach for cardiovascular disease

Yan

Sun

et al. 2023

J Transl Med

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Cardiovascular diseases (CVDs) continue to exert a significant impact on global mortality rates, encompassing conditions like pulmonary arterial hypertension (PAH), atherosclerosis (AS), and myocardial infarction (MI). Oxidative stress (OS) plays a crucial role in the pathogenesis and advancement of CVDs, highlighting its significance as a contributing factor. Maintaining an equilibrium between reactive oxygen species (ROS) and antioxidant systems not only aids in mitigating oxidative stress but also confers protective benefits on cardiac health. Herbal monomers can inhibit OS in CVDs by activating multiple signaling pathways, such as increasing the activity of endogenous antioxidant systems and decreasing the level of ROS expression. Given the actions of herbal monomers to significantly protect the normal function of the heart and reduce the damage caused by OS to the organism. Hence, it is imperative to recognize the significance of herbal monomers as prospective therapeutic interventions for mitigating oxidative damage in CVDs. This paper aims to comprehensively review the origins and mechanisms underlying OS, elucidate the intricate association between CVDs and OS, and explore the therapeutic potential of antioxidant treatment utilizing herbal monomers. Furthermore, particular emphasis will be placed on examining the cardioprotective effects of herbal monomers by evaluating their impact on cardiac signaling pathways subsequent to treatment. Graphical Abstract

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Oxidative Stress and NADPH Oxidase: Connecting Electromagnetic Fields, Cation Channels and Biological Effects

Cited by 19 publications

References 86 publications

Ion channels as molecular targets of glioblastoma electrotherapy

Ion channels as molecular targets of glioblastoma electrotherapy

Cecropin A Alleviates LPS-Induced Oxidative Stress and Apoptosis of Bovine Endometrial Epithelial Cells

Targeting oxidative stress as a preventive and therapeutic approach for cardiovascular disease

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