Oxidative Stress and Neurotoxicity of Cadmium and Zinc on Artemia franciscana

Kukavica, Biljana; Davidović-Plavšić, Biljana; Savić, Ana; Dmitrović, Dejan; Šukalo, Goran; Đurić-Savić, Sandra; Vučić, Goran

doi:10.1007/s12011-022-03352-x

Cited by 6 publications

(2 citation statements)

References 60 publications

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“…64 Dysregulation of Zn is significantly involved in ROS production and has been found to indirectly lead to redox balance disruption. 55,[65][66][67] As one of the most significant trace elements, Zn deficiencies are associated with a range of cellular and physiological effects, including oxidative stress, inflammation, and apoptosis. 65 Exerting its antioxidant effect, Zn stabilises the cell membrane, protecting against lipid oxidation.…”

Section: Titanium Dioxide Nanoparticles Dysregulate Cellular Homeosta...mentioning

confidence: 99%

Impact of nano-titanium dioxide extracted from food products on Caco-2 cells using three-phase digestion model

Jeffcoat,

Divakarla,

New

et al. 2023

Environ. Sci.: Nano

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Section: Titanium Dioxide Nanoparticles Dysregulate Cellular Homeosta...mentioning

confidence: 99%

Impact of nano-titanium dioxide extracted from food products on Caco-2 cells using three-phase digestion model

Jeffcoat,

Divakarla,

New

et al. 2023

Environ. Sci.: Nano

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“…(Muyssen and Janssen 2002 ; Oteiza 2012 ). However, its excess can induce neurotoxicity in various animal groups such as crustaceans and mammals (Szewczyk 2013 ; Kukavica et al 2023 ), while deficiency in mammals elevates the risk of neurological disorders like depression (Szewczyk 2013 ). In mammals, Zn can affect a range of receptors or transporters at pre- and post-synaptic sides (Doboszewska et al 2017 ).…”

Section: Introductionmentioning

confidence: 99%

Binary effects of fluoxetine and zinc on the biomarker responses of the non-target model organism Daphnia magna

Atli,

Sevgiler

2024

Environ Sci Pollut Res

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The antidepressant effect of zinc on mammals has been documented in recent decades, and the concentration of the antidepressant fluoxetine (FLX) in aquatic environments has been rising constantly. The aim of the present study is to evaluate the combined toxicity of a serotonin reuptake inhibitor (FLX) and Zn2+ on a non-target aquatic model organism Daphnia magna. Animals were exposed to single and binary combinations of FLX (20.5 and 41 µg/L for subchronic and 41 and 82 µg/L for acute exposures) and Zn2+ (40 µg/L for subchronic and 80 µg/L for acute exposures). In vivo experiments were done for 7 days subchronic and 48 h acute exposure, while subcellular supernatants of whole Daphnia lysate (WDL) were directly treated with the same concentrations used in the acute experiments. Morphological characteristics, Ca2+-ATPase, antioxidant enzyme activities, and lipid peroxidation were examined. There was antioxidant system suppression and Ca2+-ATPase inhibition despite the diverse response patterns due to duration, concentration, and toxicant type. After acute exposure, biomarkers showed a diminishing trend compared to subchronic exposure. According to integrated biomarker response index (IBR) analysis, in vivo Zn2+ exposure was reasonably effective on the health of D. magna, whereas exposure of WDL to Zn2+ had a lesser impact. FLX toxicity increased in a concentration-dependent manner, reversed by the combined exposure. We concluded that potential pro-oxidative and adverse Ca2+-ATPase effects of FLX and Zn2+ in D. magna may also have harmful impact on ecosystem levels. Pharmaceutical exposure (FLX) should be considered along with their potential to interact with other toxicants in aquatic biota. Graphical Abstract

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Sublethal cadmium exposure in the freshwater snail Lymnaea stagnalis meets a deficient, poorly responsive metallothionein system while evoking oxidative and cellular stress

Gnatyshyna¹,

Khoma²,

Мартынюк³

et al. 2023

Comparative Biochemistry and Physiology Part C: Toxicology &

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Oxidative Stress and Neurotoxicity of Cadmium and Zinc on Artemia franciscana

Cited by 6 publications

References 60 publications

Impact of nano-titanium dioxide extracted from food products on Caco-2 cells using three-phase digestion model

Impact of nano-titanium dioxide extracted from food products on Caco-2 cells using three-phase digestion model

Binary effects of fluoxetine and zinc on the biomarker responses of the non-target model organism Daphnia magna

Sublethal cadmium exposure in the freshwater snail Lymnaea stagnalis meets a deficient, poorly responsive metallothionein system while evoking oxidative and cellular stress

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