Oxidative Stress and Obesity

Savini, Isabella; Gasperi, Valeria; Catani, Maria Valeria

doi:10.1007/978-3-319-19821-7_6

Cited by 25 publications

(26 citation statements)

References 180 publications

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“…In recent years, assessment of MDA of tissues and plasma has been extensively used in numerous cancers including breast cancer. Various studies have examined the possibility of a relationship between lipid peroxidation and breast cancer (Gonenc et al, 2006a;Gönenç et al, 2006b;Hauck and Bernlohr, 2016;Savini et al, 2016;Sreenivasa Rao et al, 2012). Some studies have reported higher serum MDA levels in breast cancer patients (Aldini et al, 2010;Savini et al, 2016) while some have reported lower levels (Abdel-Salam et al, 2011;Gerber et al, 1996;Gonenc et al, 2006;Tas et al, 2005).…”

Section: General Characteristicsmentioning

confidence: 99%

Enzymatic antioxidant and lipid peroxidation evaluation in the newly diagnosed breast cancer patients in Iran

Kangari

Farahany

Golchin

et al. 2018

Asian Pac J Cancer Prev

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Background: Breast cancer is caused by breast tissue malignant cells and it has become one of the main medical concerns with a socio-economic significance especially for women. Among the multiple factors involved in the initiation, progression, and invasion of breast cancer, oxidative stress plays an important role. Antioxidant status, lipid peroxidation, and oxidative stress in newly diagnosed breast cancer patients were determined to find a defined pattern of oxidative stress in these patients. Methods: The malondialdehyde (MDA) levels (as an indicator of lipid peroxidation), glutathione peroxidase (GPX), and superoxide dismutase (SOD) activities of newly diagnosed breast cancer patients (n=38) and controls (n=38) were assessed using blood samples. Results: MDA level and SOD activity were significantly higher in the breast cancer patients compared to the healthy subjects group (p<0.05). Compared to the healthy group, GPX activity decreased significantly in patients group (p<0.05). Conclusions: High lipid peroxidation is an important risk factor for breast cancer and the increased levels of superoxide anion in breast cancer cells may be a reason for the induction of SOD activity. Nevertheless, oxidative stress is an important factor in development and progression of breast cancer. Further studies on it can lead to a more helpful approach to management of breast cancer.

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Section: General Characteristicsmentioning

confidence: 99%

Enzymatic antioxidant and lipid peroxidation evaluation in the newly diagnosed breast cancer patients in Iran

Kangari

Farahany

Golchin

et al. 2018

Asian Pac J Cancer Prev

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“…Superoxide radicals generated due to oxidative stress are taken up by SOD and converted to hydrogen peroxide and water. The former is in turn taken up by CAT or GPx and converted to oxygen and water (CAT) or the respective alcohol and water (GPx) depending on which enzyme catalyzed the reaction, though, GPx is more suited to hydroperoxides [11,61]. Our data showed that SOD increased copiously in the arsenic exposed group when compared with the Normal control (Fig.…”

Section: Discussionmentioning

confidence: 64%

Flavonoid-rich fractions from Clerodendrum volubile and Vernonia amygdalina extenuates arsenic-invoked hepato-renal toxicity via augmentation of the antioxidant system in rats

Ugbaja

Akinhanmi

Ugwor

et al. 2021

Clinical Nutrition Open Science

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Arsenicosis remains a global health concern due to devastating health effects. Clerodendrum volubile and vernonia amygdalina have tremendous bioactivities against oxidative stress-related diseases. The study, therefore, appraised the effects of flavonoids fractions from C. volubile and V. amygdalina (FCV and FVA respectively) against arsenic-induced oxidative stress in rats. Thirty male Wistar rats (120 ± 10 g) were divided into six groups of five each; Control (distilled water), arsenic alone (40 ppm sodium arsenite), arsenic þ FCV (100 mg/kg), arsenic þ FVA (100 mg/kg), arsenic þ FCV and FVA (50 mg/kg each), and arsenic þ vitamin C (100 mg/kg). The treatment commenced after four-week long arsenic exposure and lasted another four weeks. Blood, liver and kidneys of the rats were collected after sacrifice following an overnight fast. Arsenic caused significant (p<0.05) reductions in the total thiols levels in the plasma, liver, and kidneys, as well as the lowering of catalase and glutathione peroxidase activities.

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“…Where noticed an increase in the levels of (GPT, GOT) that the increase in enzyme activity it can lead to abnormal structural and functional changes that the occur of hepatic cells, and these changes may increase the necrosis of hepatocytes (Necrosis). Thus, the enzymes are released into the bloodstream [16] . The results of the albumin concentration showed a significant decrease, and the result was (3.004±0.456) this result was accordance with the result of (Savini et al), as this study that appears confirmed low serum albumin is associated with an increased risk developing cardiovascular disease in adults age.…”

Section: Serum Testmentioning

confidence: 99%

An Physiological Enzymatic Study for Atherosclerosis Patients in the City of Fallujah

Hadeel Abdelelah Abdel Razaaq

2021

Indian Journal of Forensic Medicine & Toxicology

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Atherosclerosis is a syndrome that affects arterial blood vessels. Arteriosclerosis thickens the walls of blood vessels as a result of accumulation of macrophages and white blood cells, and fat accumulation is more pronounced over time. Blood pressure, smoking, obesity, lifestyle, sugar and age are risk factors. Atherosclerosis. The symptoms and signs of atherosclerosis differ depending on the arteries affected by atherosclerosis.This study was conducted in the Pharma lab in the city of Fallujah and samples were collected from the Fallujah General Hospital. 50 samples were collected, 30 of which were patients with atherosclerosis and the remaining 20 samples were for healthy people. The samples included both males and females between the ages of 30 to 78 years. A questionnaire was used to collect some information from patients and corrections that included (gender, age, blood pressure, smoking, Weight and blood sugar) and some tests were performed (Cholesterol , TG, HDL, LDL, VLDL, GOT, GPT, ALP, Albumin). The results showed a significant increase in concentrations of Chol, TG, LDL, VLDL, GOT, GPT, ALP) in patients with atherosclerosis and a significant decrease in concentrations of both HDL and ALB in patients with atherosclerosis at the probability level (P ≤ 0.05). The results also showed that males are more susceptible to arteriosclerosis than Females, and also showed that the greater the age, the greater the risk factors for atherosclerosis. The more risk factors for atherosclerosis increase with increasing body mass. As for smoking, the results indicated that it has an effect on atherosclerosis, as people who smoke have increased risk factors for atherosclerosis, and disease risk factors increase with increased blood pressure and sugar.

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Oxidative Stress and Obesity

Cited by 25 publications

References 180 publications

Enzymatic antioxidant and lipid peroxidation evaluation in the newly diagnosed breast cancer patients in Iran

Enzymatic antioxidant and lipid peroxidation evaluation in the newly diagnosed breast cancer patients in Iran

Flavonoid-rich fractions from Clerodendrum volubile and Vernonia amygdalina extenuates arsenic-invoked hepato-renal toxicity via augmentation of the antioxidant system in rats

An Physiological Enzymatic Study for Atherosclerosis Patients in the City of Fallujah

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