Oxidative Stress and Oral Diseases

Subramanian, Aravind Kumar; Narayan, Vivek; Navaneethan, R

doi:10.1007/978-981-15-1568-2_1

Cited by 5 publications

(3 citation statements)

References 22 publications

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“…This may be due to the skeletal class I bony base. This is in accordance with the results of some studies [ 18 , 19 ]. Distance from central incisor roots to incisive canal (11 Rm-Cat, 21 Rm-Cat) demonstrated a significant difference between both malocclusions at all three vertical levels (L1, L2, L3) (p<0.05).…”

Section: Discussionsupporting

confidence: 94%

Cone-Beam Computed Tomography Study of Incisive Canal and Maxillary Central Incisors in Dravidian Population

Selvaraj,

Kumar Subramanian

2024

Cureus

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Introduction: En-masse maxillary anterior retraction is necessary to attain an esthetic profile in Angle's class I bimaxillary dentoalveolar protrusion and Angle's class II division 1 malocclusion. The objective of this study was to evaluate configurational relationships between maxillary incisors and incisive canal in Angle's class I bialveolar protrusion and Angle's class II division 1 malocclusion by cone-beam computed tomography (CBCT). Methods: A total of 108 adult CBCT scans of 54-skeletal class I bialveolar protrusion and 54-skeletal class II division 1 malocclusions were retrospectively analyzed. Angles between palatal plane and axis of maxillary alveolar border (θ1), incisive canal (θ2), and maxillary right central incisor (θ3) were measured in relation to the midsagittal plane. Linear measurements such as incisive canal width (IC-IC), medial inter-root distance (Rm-Rm), posterior inter-root distance (Rp-Rp), anteroposterior distance from Rm to tangent of right central incisor (11 Rm-Cat), and left central incisor (21 Rm-Cat) corresponding to three vertical levels (L1, L2, and L3) were assessed in axial cross-sectional plane. Association among angular measurements was examined by Spearman correlation coefficient analysis. Mann-Whitney U test compared variables of linear measurements at three vertical levels. Results: Estimated distance from incisor root to incisive canal was 5-6 mm in both groups slightly influenced by skeletal class and vertical levels but not gender. Mann-Whitney test demonstrated significant differences between groups at three vertical levels (p<0.05). Only θ2 revealed a significant difference (p<0.05) between malocclusions compared to θ1 and θ3. The angular measurements for both malocclusions were positively correlated (p<0.05). Conclusion: Sagittal root-canal cortical plate distance varied significantly in both malocclusions (5-6 mm). Inter-root distance (Rp-Rp) was greater than incisive canal width (IC-IC) at all three vertical levels indicating a reduced possibility of canal invasion after maximum retraction at posterior levels.

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Section: Discussionsupporting

confidence: 94%

Cone-Beam Computed Tomography Study of Incisive Canal and Maxillary Central Incisors in Dravidian Population

Selvaraj,

Kumar Subramanian

2024

Cureus

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“…LMF1 promotes LPL maturation which is then transported transendothelially and bound to its anchoring protein GPIHBP1 on the luminal surface of the endothelium. Variants in these five canonical genes affect TG metabolism and may lead to HTG [157]. The intervention of these gene products in lipolysis is shown in Figure 1.…”

Section: Hypertriglyceridemia and Atherosclerotic Cardiovascular Diseasementioning

confidence: 99%

Understanding Hypertriglyceridemia: Integrating Genetic Insights

Alves,

Laranjeira,

Correia-da-Silva

2024

Genes

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Hypertriglyceridemia is an exceptionally complex metabolic disorder characterized by elevated plasma triglycerides associated with an increased risk of acute pancreatitis and cardiovascular diseases such as coronary artery disease. Its phenotype expression is widely heterogeneous and heavily influenced by conditions as obesity, alcohol consumption, or metabolic syndromes. Looking into the genetic underpinnings of hypertriglyceridemia, this review focuses on the genetic variants in LPL, APOA5, APOC2, GPIHBP1 and LMF1 triglyceride-regulating genes reportedly associated with abnormal genetic transcription and the translation of proteins participating in triglyceride-rich lipoprotein metabolism. Hypertriglyceridemia resulting from such genetic abnormalities can be categorized as monogenic or polygenic. Monogenic hypertriglyceridemia, also known as familial chylomicronemia syndrome, is caused by homozygous or compound heterozygous pathogenic variants in the five canonical genes. Polygenic hypertriglyceridemia, also known as multifactorial chylomicronemia syndrome in extreme cases of hypertriglyceridemia, is caused by heterozygous pathogenic genetic variants with variable penetrance affecting the canonical genes, and a set of common non-pathogenic genetic variants (polymorphisms, using the former nomenclature) with well-established association with elevated triglyceride levels. We further address recent progress in triglyceride-lowering treatments. Understanding the genetic basis of hypertriglyceridemia opens new translational opportunities in the scope of genetic screening and the development of novel therapies.

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“…The oral cavity is exposed to both endogenous and exogenous sources of ROS, including physiological metabolism and external factors like food, radiation, air pollution, and tobacco use 7 . ST use has been shown to contribute to oxidative stress in the oral cavity, leading to cellular damage and increasing the risk of oral diseases such as oral cancer, dental caries, lichen planus, and chronic periodontitis 8,9 .…”

Section: Introductionmentioning

confidence: 99%

Oral Candidal Carriage and its Correlation with Salivary Oxidative Stress in Smokeless Tobacco Users

Kamal,

Shahzad,

Khan

et al. 2023

PJMHS

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Background: Smokeless tobacco use, particularly the consumption of Naswar, is prevalent in Pakistan and has been associated with various chronic diseases, including oral cancer. Naswar is known to contain toxic heavy metals, carcinogenic substances, and microbial contaminants. This study aims to assess the oral Candida carriage and biofilm formation in Candida albicans isolates from Naswar users and its association with salivary oxidative stress. Methods: A cross-sectional study was conducted involving 150 participants, divided into Naswar users (n=75) and Non-users (n=75). Socio-demographic data, oral health, hygiene practices, and Naswar usage patterns were collected through a standardized questionnaire. Salivary samples were collected, and Candida strains were identified using culture techniques. Salivary oxidative stress was assessed using a DPPH solution-based free radical system. Results: The mean age of participants was 30 ± 7.3 years for Naswar users and 30.2 ± 7.1 years for non-users. No significant differences were observed in oral health and hygiene practices between the two groups. Among Naswar users, the most common type of product used was green moist Naswar (77.3%). Oral Candida carriage was significantly higher in Naswar users, particularly those with fungal infections of C. albicans, C. krusei, or both. These participants also exhibited elevated levels of salivary oxidative stress. Practical Implication: Public health interventions and oral health education programs should be implemented to raise awareness about the risks associated with Naswar and promote good oral hygiene practices among users. Conclusion: This study reveals significant differences in oral Candida carriage and salivary oxidative stress between Naswar users and non-users, indicating potential implications for the oral health of Naswar users. These findings underscore the need for larger prospective studies to validate the detrimental effects of Naswar use. Public health interventions targeting smokeless tobacco users should prioritize oral health promotion and emphasize the risks associated with Naswar consumption. Keywords: Candida species, smokeless tobacco, oral health, oxidative stress

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Oxidative Stress and Oral Diseases

Cited by 5 publications

References 22 publications

Cone-Beam Computed Tomography Study of Incisive Canal and Maxillary Central Incisors in Dravidian Population

Cone-Beam Computed Tomography Study of Incisive Canal and Maxillary Central Incisors in Dravidian Population

Understanding Hypertriglyceridemia: Integrating Genetic Insights

Oral Candidal Carriage and its Correlation with Salivary Oxidative Stress in Smokeless Tobacco Users

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