Oxidative stress and paraoxonase 1 status in acute ischemic stroke patients

Kotur‐Stevuljević, Jelena; Bogavac-Stanojević, Nataša; Jelić‐Ivanović, Zorana; Stefanović, Aleksandra; Gojković, Tamara; Joksić, Jelena; Sopić, Miron; Gulan, Brankica; Janać, Jelena; Milošević, Sanja

doi:10.1016/j.atherosclerosis.2015.05.016

Cited by 83 publications

(59 citation statements)

References 41 publications

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“…A recent study [26] demonstrated an increase in of oxidative stress in HDL particles from patients after ischemic stroke and associated with a decrease in the anti-oxidant enzyme paraoxonase 1 activity. These authors suggested that under conditions of inflammation, oxidative stress and dyslipidemia, HDL becomes dysfunctional contributing to lower HDL-C and particle numbers.…”

Section: Discussionmentioning

confidence: 99%

HDL cholesterol and stroke risk: The Multi-Ethnic Study of Atherosclerosis

et al. 2015

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Background and Purpose Accurate identification of risk factors for stroke is important for public health promotion and disease prevention. HDL cholesterol is a potential risk factor, yet its role in stroke risk is unclear, as is whether HDL cholesterol content or particle number might be a better indicator of stroke risk. Furthermore, the degree to which ethnicity moderates the risk is unknown. As such, the current study examines the associations between incident stroke and both HDL cholesterol concentration and particle number, and assesses the moderating role of race and ethnicity. Methods The sample is a racially diverse cohort of US adults between the ages of 45 - 84 years enrolled in the Multi-Ethnic Study of Atherosclerosis between 2000 - 2002 and followed until December 2011. The associations among cholesterol content and stroke risk, particle number and stroke risk, and the interaction with race were explored. Results The incidence of stroke was 2.6%. HDL cholesterol concentration (mmol/L) (Hazard Ratio (HR) = 0.56; 95% Confidence Interval (CI): 0.312 - 0.988) and number of large HDL particles (μmol/L) (HR = 0.52, CI: 0.278 - 0.956) were associated with lower stroke risk. When interactions with race were evaluated, the relationship between both HDL variables and stroke were significant in Blacks, but not other races. Conclusions Higher HDL cholesterol and a higher concentration of large particles are associated with lower risk of stroke in Blacks. Further research is needed to elucidate the mechanisms by which HDL subfractions may differentially affect stroke outcome in different races/ethnicities.

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Section: Discussionmentioning

confidence: 99%

HDL cholesterol and stroke risk: The Multi-Ethnic Study of Atherosclerosis

et al. 2015

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“…Acute cerebral ischemia was associated with the decrease in PON activity [30]. Ferretti et al observed that disturbed PON activity was associated with severe neurological deficit [31].…”

Section: Discussionmentioning

confidence: 99%

The Early Effect of Carotid Artery Stenting on Antioxidant Capacity and Oxidative Stress in Patients with Carotid Artery Stenosis

Michalak

Ambrosius

Wysocka

et al. 2016

Oxidative Medicine and Cellular Longevity

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The treatment of carotid artery stenosis is associated with the risk of complications, which may include stroke after carotid artery stenting (CAS) and myocardial infarction after carotid endarterectomy (CEA). The imbalance between prooxidative mechanisms and antioxidant capacity creates a milieu of factors, which may increase the risk of complications after endovascular procedures. We have examined 43 consecutive patients with carotid artery stenosis. Sera were analyzed for the activity of paraoxonase (PON) and arylesterase (ARE), sulfhydryl groups (SG), malondialdehyde (MDA), and conjugated dienes (CD) concentrations by means of spectrophotometric methods before and next day after CAS. We have found lowered PON (P = 0.0032), increase in ARE activity (P = 0.0058), and decrease in sulfhydryl groups concentration (P = 0.0267). No effect on absolute MDA and CD concentrations was observed. The degree of carotid artery stenosis correlated negatively with PON/ARE ratio after CAS (r S = −0.507, P = 0.0268). To conclude, CAS influences both enzymatic (differently, PON and ARE activity) and nonenzymatic antioxidant defense. Females are more susceptible to lipid peroxidation after CAS. PON/ARE ratio after CAS correlated with the degree of carotid artery stenosis. The changes (deltas) in ARE activity, SG, and MDA concentrations correlated with the severity of neurological deficit and disability.

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“…The both parameters measured in the same sample, at the same time and under the identical reaction conditions provide opportunity to obtain comprehensive parameters which are at the opposite sides of redox balance [48][49][50]. On the other hand, total thiol groups (tSHG) of proteins are the main factors of their antioxidant potency, and they can serve as a sensitive indicator of oxidative stress [57].…”

Section: Genotoxic Antigenotoxic and Antioxidative Properties Of Barmentioning

confidence: 99%

“…Briefly, the slides were immersed in lysing solution ( The TOS was measured by a spectrophotometric method [48,49]. All oxidants such as The TAS was determined by a spectrophotometric method using 10 mmol/L ABTS as a chromogen [49,50]. The reduced ABTS molecule is oxidized to ABTS + radical cation using hydrogen peroxide in acidic medium (pH 3.6; the acetate buffer 30 mM).…”

Section: Numerical Calculationsmentioning

confidence: 99%

“…The slides with whole blood cells were prepared and gel electrophoresis was carried out as described elsewhere [46]. Briefly, the slides were immersed in lysing solution ( The TOS was measured by a spectrophotometric method [48,49]. All oxidants such as The TAS was determined by a spectrophotometric method using 10 mmol/L ABTS as a chromogen [49,50].…”

Section: Numerical Calculationsmentioning

confidence: 99%

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