2019
DOI: 10.1016/j.neulet.2019.134296
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Oxidative stress and Parkinson’s disease: conflict of oxidant-antioxidant systems

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Cited by 111 publications
(77 citation statements)
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“…Oxidative stress is a key factor in Parkinson's disease. Reactive oxygen species cause serious damage and death of dopamine-producing cells when the antioxidant capacity of the cell is reduced against oxidative stress [22,23]. For this reason, compounds may be very effective in treating PD based on in vitro and in vivo models if they demonstrated free radical scavenger effects in cell-free assays or anti-ROS influences in cell-based tests [24].…”
Section: Biological Activities Of the Isolated Compoundsmentioning
confidence: 99%
“…Oxidative stress is a key factor in Parkinson's disease. Reactive oxygen species cause serious damage and death of dopamine-producing cells when the antioxidant capacity of the cell is reduced against oxidative stress [22,23]. For this reason, compounds may be very effective in treating PD based on in vitro and in vivo models if they demonstrated free radical scavenger effects in cell-free assays or anti-ROS influences in cell-based tests [24].…”
Section: Biological Activities Of the Isolated Compoundsmentioning
confidence: 99%
“…Indeed, cellular in lammation and stress are known to cause reactive astrogliosis, which in turn leads to the generation of astrocytic ROS [147]. In this context, ROS are regarded as important modulators of PD [148,149]. At the same time, dopaminergic neurons of the substantia nigra are especially susceptible to processes of degeneration in PD [141,150].…”
Section: Parkinson's Disease and Oxidative Stressmentioning
confidence: 99%
“…Given the progressive nature of the disorder, disease pathogenesis is mainly triggered by continual processes such as geometric accumulation of oxidative radicals brought about by cellular inclusions and mitochondrial dysfunction [8][9][10] . For example, PINK1 and Parkin loss of function impair mitophagy and cause accumulation of damaged mitochondria, leading to enhanced electron leakage and formation of superoxides [11][12][13] .…”
Section: Introductionmentioning
confidence: 99%