Oxidative stress and peripartum outcomes (Review)

Simon-Szabó, Zsuzsánna; Fogarasi, Erzsébet; Nemes-Nagy, Enikő; Dénes, Lóránd; Croitoru, Mircea Dumitru; Szabó, Béla

doi:10.3892/etm.2021.10203

Cited by 18 publications

(12 citation statements)

References 61 publications

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“…Under normal conditions, the production and clearance of cellular free radicals and reactive oxygen species are in a dynamic equilibrium. SOD is a scavenger of oxygen-free radicals and plays an important role in oxidative damage (Simon-Szabo et al, 2021). Our results showed that the activities of plasma Cu 2+ -Zn 2+ -SOD gradually increased with fluid resuscitation.…”

Section: Discussionmentioning

confidence: 99%

Valproic Acid Treatment Improves Organ Function, Survival Rate, and Lipid Peroxidation in Fatally Scalded Rats

Liu,

Fu,

Jiang

et al. 2023

Pharmacognosy Magazine

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Background After hypovolemic shock caused by severe burns, lipid peroxidation is an important factor in tissue edema and multiorgan dysfunction syndrome (MODS). Many studies have shown that valproic acid (VPA) inhibits lipid peroxidation and reduces tissue and organ injury. Objectives This study investigated whether the VPA treatment of scalded rats reduced tissue edema by inhibiting lipid peroxidation, thereby improving organ function and survival rate. Materials and Methods A total of 60 male Sprague-Dawley rats (weighing: 280–300 g) with a 50% total body surface area (TBSA) full-thickness dermal burn were randomly assigned to the following 3 groups (with 20 rats per group): (I) the no infusion resuscitation (NR) group; (II) the sodium lactate Ringer’s solution (LR) group; and (III) the sodium valproate Ringer’s solution (VR) group. After scalding, the following hemodynamic parameters were measured: Copper2+-Zinc2+-superoxide dismutase (Cu2+-Zn2+-SOD) activity, thiobarbituric acid reactive substances (TBARSs), oxidized glutathione (GSSG), reduced glutathione (GSH), and antioxidant enzyme activities. Organ function parameters and water content were also measured. Another 60 male Sprague-Dawley rats were used to observe the 24-h survival rate of the rats using the same scald model and fluid resuscitation. Results VPA significantly increased the mean arterial pressure (MAP) and cardiac output (CO), and significantly decreased the pulmonary vascular permeability index (PVPI) and extravascular lung water index (ELWI). VPA also increased plasma Cu2+-Zn2+-SOD activity and decreased the plasma TBARS level. VPA reduced the TBARS level and GSSG in various tissues and increased the concentration of GSH. VPA decreased glutathione peroxidase (GPx) and catalase (CAT) activity, but significantly increased glutathione reductase (GR) activity in various tissues. VPA significantly improved organ functions and decreased water content. VPA significantly improved the survival rate, and the 24-h survival rate of the VR group was double that of the LR group. Conclusion Resuscitation with VPA reduced tissue edema, protected visceral functions, and improved the survival rate of rats with severe burn shock (BS) by alleviating lipid peroxidation.

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Section: Discussionmentioning

confidence: 99%

Valproic Acid Treatment Improves Organ Function, Survival Rate, and Lipid Peroxidation in Fatally Scalded Rats

Liu,

Fu,

Jiang

et al. 2023

Pharmacognosy Magazine

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“…Antioxidants could have potential beneficial effects on pregnancy complications such as PE, FGR and PTB. Their principal mechanisms comprise anti-inflammatory, antiapoptotic and anti-angiogenic effects, as well as the ability to restore redox homeostasis [136]. For these reasons, the interest in their use during the perinatal period has grown.…”

Section: Discussionmentioning

confidence: 99%

Effects of Antioxidant Intake on Fetal Development and Maternal/Neonatal Health during Pregnancy

et al. 2022

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During pregnancy, cycles of hypoxia and oxidative stress play a key role in the proper development of the fetus. Hypoxia during the first weeks is crucial for placental development, while the increase in oxygen due to the influx of maternal blood stimulates endothelial growth and angiogenesis. However, an imbalance in the number of oxidative molecules due to endogenous or exogenous factors can overwhelm defense systems and lead to excessive production of reactive oxygen species (ROS). Many pregnancy complications, generated by systemic inflammation and placental vasoconstriction, such as preeclampsia (PE), fetal growth restriction (FGR) and preterm birth (PTB), are related to this increase of ROS. Antioxidants may be a promising tool in this population. However, clinical evidence on their use, especially those of natural origin, is scarce and controversial. Following PRISMA methodology, the current review addresses the use of natural antioxidants, such as epigallocatechin gallate (EGCG), melatonin and resveratrol (RESV), as well as other classical antioxidants (vitamin C and E) during the prenatal period as treatment of the above-mentioned complications. We review the effect of antioxidant supplementation on breast milk in lactating mothers.

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“…Oxidative stress occurs when there is an imbalance between reactive oxygen species (ROS) ( 1 ) and reactive nitrogen species (RNS) ( 2 ) and the innate antioxidant systems. Under normal circumstances, the perinatal period is propagated by a balanced ROS production for the maternal-fetal dyad.…”

Section: Oxidative Stress and The Perinatal Periodmentioning

confidence: 99%

Educational Review: The Impact of Perinatal Oxidative Stress on the Developing Kidney

et al. 2022

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Oxidative stress occurs when there is an imbalance between reactive oxygen species/reactive nitrogen species and antioxidant systems. The interplay between these complex processes is crucial for normal pregnancy and fetal development; however, when oxidative stress predominates, pregnancy related complications and adverse fetal programming such as preterm birth ensues. Understanding how oxidative stress negatively impacts outcomes for the maternal-fetal dyad has allowed for the exploration of antioxidant therapies to prevent and/or mitigate disease progression. In the developing kidney, the negative impact of oxidative stress has also been noted as it relates to the development of hypertension and kidney injury mostly in animal models. Clinical research addressing the implications of oxidative stress in the developing kidney is less developed than that of the neurodevelopmental and respiratory conditions of preterm infants and other vulnerable neonatal groups. Efforts to study the oxidative stress pathway along the continuum of the perinatal period using a team science approach can help to understand the multi-organ dysfunction that the maternal-fetal dyad sustains and guide the investigation of antioxidant therapies to ameliorate the global toxicity. This educational review will provide a comprehensive and multidisciplinary perspective on the impact of oxidative stress during the perinatal period in the development of maternal and fetal/neonatal complications, and implications on developmental programming of accelerated aging and cardiovascular and renal disease for a lifetime.

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Oxidative stress and peripartum outcomes (Review)

Cited by 18 publications

References 61 publications

Valproic Acid Treatment Improves Organ Function, Survival Rate, and Lipid Peroxidation in Fatally Scalded Rats

Valproic Acid Treatment Improves Organ Function, Survival Rate, and Lipid Peroxidation in Fatally Scalded Rats

Effects of Antioxidant Intake on Fetal Development and Maternal/Neonatal Health during Pregnancy

Educational Review: The Impact of Perinatal Oxidative Stress on the Developing Kidney

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