Oxidative stress and potential interventions to reduce oxidative stress in overweight and obesity

Vincent, Heather K.; Innes, Kim E.; Vincent, Kevin R.

doi:10.1111/j.1463-1326.2007.00692.x

Cited by 369 publications

(291 citation statements)

References 166 publications

(312 reference statements)

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“…The most interesting outcome, however, came from the assessment of CAT, which is a quite important enzyme. This protein converts peroxide in water, leading to its inactivation [11][12][13][14][15][16] . On the presence of warm ischemia followed by reperfusion, the CAT usually rises in order to protect against the lipid peroxidation.…”

Section: Discussionmentioning

confidence: 99%

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Oxidative stress evaluation of ischemia and reperfusion in kidneys under various degrees of hypothermia in rats

Santos

Koff

Filho³

et al. 2013

Acta Cir. Bras.

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PURPOSE:To design an animal model of ischemia-reperfusion (I/R) in kidneys and evaluate the role that predetermined ranges of local hypothermia plays on markers of stress-oxydative as well as on histologic sections. METHODS:Twenty eight male rats Wistar, under general anesthesia, undergone right nephrectomy (G0, control group) followed by left kidney ischemia during 40 min. Four temperatures groups were designed, with seven animals randomized for each group: normothermic (G1, ±37 o C), mild hypothermia (G2, 26 o C), moderate hypothermia (G3, 15 o C) and deep hypothermia (G4, 4 o C). Left kidney temperature was assessed with an intraparenchymal probe. Left nephrectomy was performed after 240 min of reperfusion. After I/R a blood sample was obtained for f2-IP. Half of each kidney was sent to pathological evaluation and half to analyze CAT, SOD, TBARS, NO 3 , NO 2 . RESULTS:Histopathology showed that all kidneys under I/R were significantly more injured than the G0 (p<0.001). TBARS had increased levels in all I/R groups compared with the G0 (p<0.001). CAT had a significant difference (p<0.03) between G1 and G4. Finally, no difference was found on SOD, NO 3 , NO 2 nor on f2-IP. CONCLUSION:This model of I/R was efficient to produce oxidative-stress in the kidney, showing that 4ºC offered significant decrease in free radicals production, although tissue protection was not observed.

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Section: Discussionmentioning

confidence: 99%

“…In order to evaluate the role played by free radicals, indirect markers are usually searched [11][12][13][14] , because it is difficult to perform straight assessment of such unstable reactive species 15 . The antioxidant activity is measured through enzymes as superoxide dismutase (SOD) and catalase (CAT).…”

Section: Methodsmentioning

confidence: 99%

Oxidative stress evaluation of ischemia and reperfusion in kidneys under various degrees of hypothermia in rats

Santos

Koff

Filho³

et al. 2013

Acta Cir. Bras.

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“…Oxidative stress increases with ageing [36] as it is involved in virtually all the diseases associated with obesity [37]. Obesity causes an increase of interleukin (IL) 1, IL-6, tumour necrosis factor, C-reactive protein, cholesterol and triglycerides, excessive hormone production (the renin-angiotensin system hormones) and insulin resistance.…”

Section: Oxidative Stressmentioning

confidence: 99%

“…Obesity causes an increase of interleukin (IL) 1, IL-6, tumour necrosis factor, C-reactive protein, cholesterol and triglycerides, excessive hormone production (the renin-angiotensin system hormones) and insulin resistance. With advancing age, these aforementioned changes, in combination with the low antioxidant intake and physical activity, contribute to the exacerbation of the oxidative stress [37]. Moderate physical activity may generate mild oxidative stress that activates cellular stress response which signals and potentiates cellular antioxidant defence capacity whereas exhaustive exercise may cause accumulation of reactive oxygen species that can damage DNA, cause mutations or promote carcinogenesis (38).…”

Section: Oxidative Stressmentioning

confidence: 99%

Healthy aging and age-adjusted nutrition and physical fitness

Hammar

Östgren

2013

Best Practice & Research Clinical Obstetrics & Gynaecol

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(154 words)The expected life span is gradually increasing worldwide. For healthy ageing there are a number of options that may be used including healthy dietary and exercise habits. To reduce or prevent obesity certain types of diet may be used that will also reduce the risk of, e.g., cardiovascular disease (CVD). Exercise reduces the risk of diseases like CVD, osteoporosis, some cancers and some mental disturbances. Decreasing a sedentary life style seems at least as important as regular exercise. Exercise can probably be tailored to reduce the risk of CVD and extent of bone loss. To insure adherence, it is important to slowly increase the frequency, duration and intensity of exercise and to find activities that suit the individual. More research has to be done in order to find the ideal modes and doses of exercise and to increase long-term adherence. Both dietary and exercise modification seem to be strong promoters of healthy ageing.Healthy aging and age adjusted nutrition and physical fitness Hammar M, Östgren CJ

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“…The results obtained for plasma samples from healthy and hypercholesterolemic guinea 319 pigs confirmed this fact (Figure 3), as plasma LDL cholesterol levels were 16 ± 6.3 and 266 ± 320 108 mg dL -1 , respectively. Furthermore, oxidative stress is commonly associated with obesity 321 and hypercholesterolemia [3,36]. Using the proposed method, results for total HP from 322 healthy guinea pigs fed a standard diet were 24.7 ± 2.2 µM of CHP eq., but after consumption 323 of hypercholesterolemic diets plasma oxidation levels increased up to 31.0 ± 3.9 µM of CHP 324 eq.…”

mentioning

confidence: 99%

Determination of total plasma hydroperoxides using a diphenyl-1-pyrenylphosphine fluorescent probe

Santas

Guardiola

Rafecas

et al. 2013

Analytical Biochemistry

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19Plasma hydroperoxides (HP) are widely accepted to be good indicators of oxidative stress. By 20 means of the method proposed herein, which uses diphenyl-1-pyrenylphosphine (DPPP) as a 21 fluorescent probe, all types of plasma HP were determined. The detection and quantification 22 limits of the method were 0.08 and 0.25 nmols of cumene hydroperoxide (CHP) equivalents 23 in 40 µL of plasma, respectively. The method is satisfactory in terms of precision (5.3% for 24 14.5 µM CHP eq.; n=8) and the recoveries were 91% and 92% after standard additions of 26 25 and 52 µM of CHP, respectively. The selectivity of the proposed method is higher than 96%. 26Moreover, optimization of the reaction conditions and the addition of 27 ethylenediaminetetraacetic acid (EDTA) disodium salt and 2,6-di-tert-butyl-4-methylphenol 28 (BHT) prevented the formation of HP artifacts during the analysis. Therefore, the proposed 29 method is useful for simple and quantitative determination of total plasma HP. 30 31

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Oxidative stress and potential interventions to reduce oxidative stress in overweight and obesity

Abstract: Oxidative stress is related to chronic disease in obesity, but is reversible with one or more interventions described above.

Cited by 369 publications

References 166 publications

Oxidative stress evaluation of ischemia and reperfusion in kidneys under various degrees of hypothermia in rats

Oxidative stress evaluation of ischemia and reperfusion in kidneys under various degrees of hypothermia in rats

Healthy aging and age-adjusted nutrition and physical fitness

Determination of total plasma hydroperoxides using a diphenyl-1-pyrenylphosphine fluorescent probe

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