Oxidative Stress and Serum S100b Levels in Adolescents With First-Episode
            Drug-Naive Unipolar Depression

Menculini, Giulia; Moretti, Patrizia; Pandolfi, Luigi Maria; Bianchi, S.; Valentini, Eleonora; Gatto, Mattia; Amantini, K.; Tortorella, Alfonso

doi:10.24869/psyd.2021.158

Cited by 15 publications

(12 citation statements)

References 22 publications

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“…Similar to our study, some studies have shown that in MDD, oxidative stress parameters increase and in severe depressive symptoms antioxidant capacity decreases [4]. In a study conducted with adolescents with unipolar depression, TOS, OSI and MDA values were higher while the TAS values were lower compared to their healthy peers [11]. However, in a study comparing TAS levels and cognitive functions in patients with recurrent depression and healthy controls, it was shown that high TAS levels were associated with depression severity both before and after treatment and reflected cognitive deterioration [15].…”

Section: Discussionsupporting

confidence: 89%

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Childhood depression and oxidative stress

Miniksar

Göçmen

2022

Egypt J Neurol Psychiatry Neurosurg

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Background Oxidative stress is a contributing factor in the etiopathogenesis of major depressive disorder (MDD). Pediatric studies regarding MDD-oxidative stress relationship are insufficient. In this study, we aimed to compare oxidative stress parameters of pediatric MDD patients with those of the control group and to examine factors affecting these parameters. Results Total oxidant status (TOS), total antioxidant status (TAS), oxidative stress index (OSI), malondialdehyde (MDA) and superoxide dismutase (SOD) activities of 42 patients with MDD and 38 healthy controls were evaluated. Children depression inventory (CDI) was applied to all participants. In the MDD group, serum levels of TOS, OSI and MDA were higher, while TAS and SOD levels were lower (p < 0.001). When all participants were examined, oxidative stress increased as the CDI score increased, but in the MDD group, SOD increased as the CDI score increased. Increase in body mass index (BMI) percentile increased the oxidative stress in the MDD group. When factors affecting the presence of MDD were analyzed by binary logistic regression analysis, a one-unit increase in SOD decreased depression by 0.190 times. Conclusions This study showed that oxidative stress increases in children and adolescents with MDD, and the increase in the severity of depression further increases oxidative stress, but when the depression becomes very severe, level of SOD increases compensatorily. It has been observed that high BMI in MDD patients creates an additional burden on oxidative stress. The role of oxidative stress in the etiopathogenesis of MDD in children and adolescents should be evaluated more comprehensively.

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Section: Discussionsupporting

confidence: 89%

“…Levels of superoxide dismutase (SOD), one of the antioxidant defense system enzymes, were shown to be low in adults with MDD [10]. Adolescents with unipolar depression were reported to have higher TOS, OSI, and MDA values, and lower TAS than their healthy peers [11].…”

Section: Introductionmentioning

confidence: 99%

Childhood depression and oxidative stress

Miniksar

Göçmen

2022

Egypt J Neurol Psychiatry Neurosurg

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“…There are only two studies exclusively on adolescent groups concerning S100B levels, and opposite results were reported: decreased [ 62 ] or elevated S100B levels [ 63 ] in adolescent MDD patients compared to HC.…”

Section: Resultsmentioning

confidence: 99%

Peripheral S100B Protein Levels in Five Major Psychiatric Disorders: A Systematic Review

Kozlowski,

Bargiel,

Grabarczyk

et al. 2023

Brain Sciences

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Five major psychiatric disorders: schizophrenia, major depressive disorder, bipolar disorder, autistic spectrum disorder, and attention-deficit/hyperactivity disorder, show a shared genetic background and probably share common pathobiological mechanisms. S100B is a calcium-binding protein widely studied in psychiatric disorders as a potential biomarker. Our systematic review aimed to compare studies on peripheral S100B levels in five major psychiatric disorders with shared genetic backgrounds to reveal whether S100B alterations are disease-specific. EMBASE, Web of Science, and PubMed databases were searched for relevant studies published until the end of July 2023. This study was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-analysis Protocols (PRISMA) guidelines. Overall, 1215 publications were identified, of which 111 full-text articles were included in the systematic review. Study designs are very heterogeneous, performed mostly on small groups of participants at different stages of the disease (first-episode or chronic, drug-free or medicated, in the exacerbation of symptoms or in remission), and various clinical variables are analyzed. Published results are inconsistent; most reported elevated S100B levels across disorders included in the review. Alterations in S100B peripheral levels do not seem to be disease-specific.

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“…However, no significant difference was found in serum S‐100β levels between patients with post‐stroke depression and patients without post‐stroke depression. In fact, there is still controversy about the relationship between serum S‐100β levels and depression 35–37 . Although anxiety disorder and depression disorder have overlapping biological mechanisms such as decreased serotonin levels in the brain, the changes of neurotransmitters in the brain are not completely consistent 38–40 .…”

Section: Discussionmentioning

confidence: 99%

“…In fact, there is still controversy about the relationship between serum S-100β levels and depression. [35][36][37] Although anxiety disorder and depression disorder have overlapping biological mechanisms such as decreased serotonin levels in the brain, the changes of neurotransmitters in the brain are not completely consistent. [38][39][40] Depression disorder is associated with decreased levels of dopamine and norepinephrine, 41,42 while anxiety disorder is associated with increased levels of these substances.…”

Section: Discussionmentioning

confidence: 99%

The relationship between serum levels of S‐100β and anxiety symptoms in patients with acute stroke

Wang

Xiao

et al. 2022

Psychogeriatrics

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Background: Post-stroke anxiety (PSA) is a common neuropsychiatric affective disorder occurring after a stroke. Animal experiments have indicated that serum S-100β levels are closely related to anxiety disorder. No clinical study has been done to explore the relationship between serum S-100β levels and anxiety symptoms in patients with acute stroke. The aim of our study was to investigate the association between serum S-100β levels and PSA. Methods: One hundred twenty-six acute stroke patients were recruited and followed up for 1 month. Blood samples were collected within 24 h after admission. The levels of serum S-100β were measured by enzyme-linked immunosorbent assays. Patients with significant clinical symptoms of anxiety and a Hamilton Anxiety Rating Scale score >7 at 1 month after stroke were diagnosed as PSA. Results: Serum S-100β levels in the non-PSA group were lower than the PSA group (838.97 (678.20-993.59) ng/L vs. 961.87 (796.09-1479.59) ng/L, Z = À2.661, P = 0.008). In multivariate analyses, we found that decreased risk of PSA was associated with low tertile serum S-100β levels (≤753.8 ng/L, OR 0.062, 95% CI 0.008-0.475, P = 0.007). Conclusions: Low serum S-100β levels at admission may be associated with the decreased risk of PSA.

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Oxidative Stress and Serum S100b Levels in Adolescents With First-Episode Drug-Naive Unipolar Depression

Cited by 15 publications

References 22 publications

Childhood depression and oxidative stress

Childhood depression and oxidative stress

Peripheral S100B Protein Levels in Five Major Psychiatric Disorders: A Systematic Review

The relationship between serum levels of S‐100β and anxiety symptoms in patients with acute stroke

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