Oxidative Stress and Tumor Markers in Cervical Cancer Patients

Abstract

Cervical carcinoma is the second most common cancer worldwide. The extent of free radical induced oxidative stress can be exacerbated by the decreased efficiency of antioxidant defense mechanisms. Low levels of essential antioxidants in the circulation have been found to be associated with an increased risk of cancer. The aim of our study was to assess the extent of oxidative stress, the levels of antioxidants like superoxide dismutase (SOD), catalase (CAT), ceruloplasmin and to evaluate tumor markers such as aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP) and total sialic acid (TSA) levels in circulation of women with cervical carcinoma and to compare our findings with age matched controls. Low levels of SOD and CAT observed in the circulation of cervical cancer patients may be due to their increased utilization to scavenge lipid peroxides as well as sequestration by tumor cells. Higher levels of TSA, AST, ALT and ALP, in the circulation of cervical cancer patients may be used in the diagnosis and treatment monitoring of patients with cervical carcinoma.

A comparative study of serum protein-bound sialic acid in benign and malignant prostatic growth: possible role of oxidative stress in sialic acid homeostasis

“…[13][14][15][16] In the present study, we found significant association between oxidative stress parameters and sialoglycoproteins. In carcinoma prostate, lipid peroxides and protein carbonyls were positively correlated with PSA and protein-bound sialic acid.…”

“…[13][14][15][16] Pasquale et al 17 demonstrated an association between lipid peroxides and PSA. Although oxidative stress and increase in sialoglycoprotein level and/or sialic acid content are reported in Ca prostate separately; however there are no reports correlating oxidative stress with sialylation parameters in both BPH and Ca prostate.…”

Biochemical Evaluation of Glycoprotein Components, Lysosomal Enzymes and Marker Enzymes upon Kalpaamruthaa Administration in Experimental Mammary Carcinoma Rats

“…The increased serum sialic acid level in tumour patients has been explained by a spontaneous release (shedding) of aberrant sialic acid-containing cell surface glycoconjugates. 39) On drug treatment, glycoprotein component levels were reverted back to near normal levels. This could be due to the cytostabilizing property of KA as it contains SA and EO as its principle components.…”

Estrés oxidativo, prooxidantes y enfermedad de Crohn

“…Se considera mediador del daño vascular de enfermedades cardiovasculares como hipertensión, ateroesclerosis e isquemiareperfusión 21 . Su presencia se asocia también con varios tumores, como próstata 22 , cuello uterino 23 , ovario 24 y de hígado 25 .…”