Oxidative Stress as a Risk Factor for Hearing Changes in HIV-positive Normal Listeners

Matas, Carla Gentile; Padilha, Fernanda Y O M M; Angrisani, Rosanna Mg; Samelli, Alessandra Giannella

doi:10.6061/clinics/2020/e1845

Cited by 4 publications

(4 citation statements)

References 44 publications

(47 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although this procedure might have compromised the p-values calculated in the present study due to a possible violation of the assumption of independence of observations, it may be an interesting move in order to reduce the number of measures to be analyzed in clinical practice and to increase statistical power of the sample. It is also worth noting that grouping the ears together is a data analysis procedure used in other studies in the audiology field (e.g., [ 60 , 61 , 62 , 63 , 64 ]). Another limitation might be the predominance of female subjects in our sample, although previous research found no difference between genders regarding BMT performance [ 31 ].…”

Section: Discussionmentioning

confidence: 99%

Evidence of Validity and Normative Values of a New Auditory Backward Masking Test

Filippini

Filho

Barros

et al. 2022

JCM

View full text Add to dashboard Cite

There are still no valid, clinically feasible instruments to assess backward masking (BM), an auditory temporal processing (ATP) phenomenon. The aim of this study was to develop, standardize and present evidence of validity for a behavioral test for BM assessment. Young adults were submitted to a BM test (BMT), where they were asked to identify a 1000 Hz pure tone followed by a narrowband noise with interstimulus intervals of 0 to 400 ms and signal-to-noise ratio (SNR) between −20 and −30 dB. The correct response rate and target sound detection threshold were calculated, and the results compared with those of young adults with abnormal ATP tests and older adults. Diagnostic accuracy analyses were carried out. Young adults with normal ATP obtained an average correct response rate of 89 and 87% for SNR −20 and −30 dB, respectively, with average thresholds between 10 and 15 ms and no difference between the left and right ears. Results were more consistent at SNR −20 dB, and the best diagnostic accuracy was obtained for SNR −20 dB, with good specificity, but low sensitivity. Normative values were obtained for the BMT, which proved to be clinically feasible, with preliminary evidence of validity.

show abstract

Section: Discussionmentioning

confidence: 99%

Evidence of Validity and Normative Values of a New Auditory Backward Masking Test

Filippini

Filho

Barros

et al. 2022

JCM

View full text Add to dashboard Cite

show abstract

“…Although combined antiretroviral therapy (cART) cannot totally remove viral proteins from the brain, it can systemically limit viral replication and partially restore immunological functions. [2] Prior research suggested that individuals with HIV-associated neurocognitive disorders exhibit dysfunction in high-order cognitive processes like attention/working memory, abstract/executive control, memory (learn and recognition), and speed of information processing in addition to low-level sensory processing [3][4][5]. [6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Altered Brain Functional Connectome Hierarchical Organization in HIV Patients

Liu#,

Xia,

Wang#

et al. 2023

Preprint

View full text Add to dashboard Cite

Background Research from the past has shown that the human immunodeficiency virus (HIV) can quickly enter the central nervous system after seroconversion, and that roughly 50% of HIV patients may experience neurological problems. Application of combined antiretroviral therapy (cART) can systemically inhibit viral replication, partially restoring immune functions, but it is unable to entirely eradicate viral proteins in the brain. The influence of HIV on brain functioning and behavioral symptoms is still completely unknown, despite extensive research into the functional and anatomical abnormalities in the brainof HIV patients. Methods We gathered resting-state functional MRI data from 77 individuals (42 HIV patients (with behavioral data) and 35 healthy controls) from Beijing YouAn Hospital, Capital Medical University. We identified a constrained primary-to-transmodal gradient and an extended sensorimotor-to-visual gradient using functional connectome gradient analysis. Results According to group comparison analysis, the HIV patients had higher sensorimotor-to-visual and sensorimotor-to-visual spatial variation in the posterior cingulate cortex and a lower gradient score of primary-to-transmodal in the middle frontal gyrus. These two abnormal functional gradients of HIV patients were related to individual decreased abstract/executive processing abilities (planning, reasoning, set switching, flexible thinking, and updating, etc.) and clinical symptoms (CD4), as well as topological efficiency of brain functional network. Conclusion When taken as a whole, our findings describe the failure of the brain's functional hierarchical architecture in HIV patients, offering a novel perspective on the neurological mechanisms driving the virus.

show abstract

“…It is known that otitis media can cause temporary hearing loss and must be treated at the periphery so that adequate medical treatment can be instituted. These individuals may also exhibit cochlear pathology/inner ear disorders due to direct viral action and use of antiretroviral drugs and/or potentially ototoxic drugs, which can cause sensorineural hearing loss (Carla G Matas et al 2020).…”

Section: Introductionmentioning

confidence: 99%

Autological Manifestations of HIV/AIDS Patients

Assauri

2022

KESANS

View full text Add to dashboard Cite

Human immunodeficiency virus (HIV) / acquired immunodeficiency syndrome (AIDS) infection is a global pandemic. An estimated 34 million people are currently infected with this virus worldwide, two-thirds of whom live in sub-Saharan Africa; 50% are women and 2.5 million are under 15 years old. AIDS is a deadly disease that weakens the body's immune system, leaving the victim vulnerable to life-threatening opportunistic infections, neurological disorders, or unusual malignancies. Approximately 80% of HIV patients are initially infected with ENT symptoms. Manifestations of AIDS in the head and neck area can affect the skin, ear, upper aerodigestive tract, and neck. Objective: To determine the otologic manifestations that occur in patients infected with Human immunodeficiency virus (HIV) / acquired immunodeficiency syndrome (AIDS). Design and Method: Literature-review. Conclusion: Ontological manifestations are signs and symptoms that occur in patients related to the ear and do not require an audiological examination to identify them. There is evidence that 30-50% of adults with HIV/AIDS have hearing loss, with this rate being higher in pediatric patients with HIV. It is often accompanied by symptoms such as ear pain, otorrhea, dizziness, and hearing loss. The current standard of care is to treat people with HIV infection with antiretroviral therapy (ART) as soon as possible, both to improve their own health and to reduce the risk of transmitting HIV to others. In the world, there are 23 million people currently living on ART medication Keyword: Human immunodeficiency virus (HIV), acquired immunodeficiency syndrome (AIDS), manifestation, otologic.

show abstract

Oxidative Stress as a Risk Factor for Hearing Changes in HIV-positive Normal Listeners

Cited by 4 publications

References 44 publications

Evidence of Validity and Normative Values of a New Auditory Backward Masking Test

Evidence of Validity and Normative Values of a New Auditory Backward Masking Test

Altered Brain Functional Connectome Hierarchical Organization in HIV Patients

Autological Manifestations of HIV/AIDS Patients

Contact Info

Product

Resources

About