Oxidative Stress at Birth Is Associated with the Concentration of Iron and Copper in Maternal Serum

Rak, Karolina; Łoźna, Karolina; Styczyńska, Marzena; Bobak, Łukasz; Bronkowska, Monika

doi:10.3390/nu13051491

Cited by 6 publications

(7 citation statements)

References 101 publications

(151 reference statements)

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“…The precise relationship between Cu and OS levels is not yet fully understood. A recent study by Rak et al [124] revealed a negative correlation between OS levels in male newborns and the concentration of Cu in maternal serum, which suggests a potential influence of Cu on OS during pregnancy, emphasizing the need for further research in this area.…”

Section: Coppermentioning

confidence: 99%

“…In pregnant women without Fe deficiency anemia (IDA), prophylactic Fe supplementation has been shown to induce OS and compromise the overall antioxidant capacity of the body [124,131]. Specifically, Rak et al [124] established a correlation between excessive Fe concentrations exceeding 400 µg/dL in the blood of pregnant women and elevated levels of OS in neonates.…”

Section: Ironmentioning

confidence: 99%

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Oxidative Stress in Pregnancy

Grzeszczak,

Łanocha-Arendarczyk,

Malinowski

et al. 2023

Biomolecules

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Recent years have seen an increased interest in the role of oxidative stress (OS) in pregnancy. Pregnancy inherently heightens susceptibility to OS, a condition fueled by a systemic inflammatory response that culminates in an elevated presence of reactive oxygen species (ROS) and reactive nitrogen species (RNS) in the circulatory system. The amplified OS in pregnancy can trigger a series of detrimental outcomes such as underdevelopment, abnormal placental function, and a host of pregnancy complications, including pre-eclampsia, embryonic resorption, recurrent pregnancy loss, fetal developmental anomalies, intrauterine growth restriction, and, in extreme instances, fetal death. The body’s response to mitigate the uncontrolled increase in RNS/ROS levels requires trace elements that take part in non-enzymatic and enzymatic defense processes, namely, copper (Cu), zinc (Zn), manganese (Mn), and selenium (Se). Determination of ROS concentrations poses a challenge due to their short half-lives, prompting the use of marker proteins, including malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione reductase (GR), catalase (CAT), and glutathione (GSH). These markers, indicative of oxidative stress intensity, can offer indirect assessments of pregnancy complications. Given the limitations of conducting experimental studies on pregnant women, animal models serve as valuable substitutes for in-depth research. This review of such models delves into the mechanism of OS in pregnancy and underscores the pivotal role of OS markers in their evaluation.

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Section: Coppermentioning

confidence: 99%

Section: Ironmentioning

confidence: 99%

Oxidative Stress in Pregnancy

Grzeszczak,

Łanocha-Arendarczyk,

Malinowski

et al. 2023

Biomolecules

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“…The procedure for obtaining and storing MS samples was the same as for the UCS. The method of determining the concentration of macro-(Ca, Mg) and microelements (Zn, Fe, Cu) in the MS has been described in detail previously [44]. The concentrations of examined macro-and microelements in the MS were categorized based on reference values for women in the 3rd trimester of pregnancy (Table 2) [45].…”

Section: Determination In Maternal Serum Of Selected Macro-and Microe...mentioning

confidence: 99%

Some Immune Parameters of Term Newborns at Birth Are Associated with the Concentration of Iron, Copper and Magnesium in Maternal Serum

et al. 2023

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The nutritional status of pregnant women is considered to affect fetal development and the health condition of newborns, including their immune system. We investigated the relationship between the concentrations of magnesium (Mg), calcium (Ca), zinc (Zn), iron (Fe) and copper (Cu) in maternal serum (MS) and the concentrations of IgG antibodies and antineutrophil cytoplasmatic auto-antibodies against lactoferrin (Lf-ANCA) in umbilical cord serum (UCS). IgG was considered as a promoter of immunity, and Lf-ANCA as an inhibitor. The examined group consisted of 98 pregnant women and their healthy term newborn children. The concentrations of mineral elements were measured by FAAS/FAES, while the concentrations of antibodies were determined by ELISA. Excessive MS Fe and insufficient MS Cu were related to insufficient UCS IgG and excessive UCS Lf-ANCA. The correlation analysis showed confirming results. Adequate UCS IgG and Lf-ANCA were related to MS Mg at the strictly lower limit of the reference values. The results obtained seem to suggest that an excess of Fe and a deficiency of Cu in pregnancy may adversely affect some immune parameters of newborns. Reference values for MS Mg are likely to require reconsideration. It would be advisable to monitor the nutritional status of pregnant women with minerals in order to support the immune capacity of newborns.

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“…The research has indicated that excess Fe saturation during the prenatal period may elevate the risks of miscarriage, premature birth, low birth weight, and being small for gestational age (SGA), with OS being one of the likely mechanisms behind these abnormalities. In pregnant women without Fe deficiency anemia (IDA), prophylactic Fe supplementation has been observed to trigger oxidative stress and limit the organism's antioxidant capacity [30,31].…”

Section: Introductionmentioning

confidence: 99%

The Trace Element Concentrations and Oxidative Stress Parameters in Afterbirths from Women with Multiple Pregnancies

et al. 2023

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The aim of this study was to evaluate the intensity of oxidative stress by measuring the concentrations of lipid peroxidation products (LPO) in fetal membrane, umbilical cord, and placenta samples obtained from women with multiple pregnancies. Additionally, the effectiveness of protection against oxidative stress was assessed by measuring the activity of antioxidant enzymes, including superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX), and glutathione reductase (GR). Due to the role of iron (Fe), copper (Cu), and zinc (Zn) as cofactors for antioxidant enzymes, the concentrations of these elements were also analyzed in the studied afterbirths. The obtained data were compared with newborn parameters, selected environmental factors, and the health status of women during pregnancy to determine the relationship between oxidative stress and the health of women and their offspring during pregnancy. The study involved women (n = 22) with multiple pregnancies and their newborns (n = 45). The Fe, Zn, and Cu levels in the placenta, umbilical cord, and fetal membrane were determined using inductively coupled plasma atomic emission spectroscopy (ICP-OES) using an ICAP 7400 Duo system. Commercial assays were used to determine SOD, GPx, GR, CAT, and LPO activity levels. The determinations were made spectrophotometrically. The present study also investigated the relationships between trace element concentrations in fetal membrane, placenta, and umbilical cord samples and various maternal and infant parameters in women. Notably, a strong positive correlation was observed between Cu and Zn concentrations in the fetal membrane (p = 0.66) and between Zn and Fe concentrations in the placenta (p = 0.61). The fetal membrane Zn concentration exhibited a negative correlation with shoulder width (p = −0.35), while the placenta Cu concentration was positively correlated with placenta weight (p = 0.46) and shoulder width (p = 0.36). The umbilical cord Cu level was positively correlated with head circumference (p = 0.36) and birth weight (p = 0.35), while the placenta Fe concentration was positively correlated with placenta weight (p = 0.33). Furthermore, correlations were determined between the parameters of antioxidative stress (GPx, GR, CAT, SOD) and oxidative stress (LPO) and the parameters of infants and maternal characteristics. A negative correlation was observed between Fe and LPO product concentrations in the fetal membrane (p = −0.50) and placenta (p = −0.58), while the Cu concentration positively correlated with SOD activity in the umbilical cord (p = 0.55). Given that multiple pregnancies are associated with various complications, such as preterm birth, gestational hypertension, gestational diabetes, and placental and umbilical cord abnormalities, research in this area is crucial for preventing obstetric failures. Our results could serve as comparative data for future studies. However, we advise caution when interpreting our results, despite achieving statistical significance.

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Oxidative Stress at Birth Is Associated with the Concentration of Iron and Copper in Maternal Serum

Cited by 6 publications

References 101 publications

Oxidative Stress in Pregnancy

Oxidative Stress in Pregnancy

Some Immune Parameters of Term Newborns at Birth Are Associated with the Concentration of Iron, Copper and Magnesium in Maternal Serum

The Trace Element Concentrations and Oxidative Stress Parameters in Afterbirths from Women with Multiple Pregnancies

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