Oxidative stress before and after surgery in benign prostatic hyperplasia patients

Abstract

The aim was to assess oxidative stress in benign prostatic hyperplasia patients and also to evaluate the effect of operation in late (60 days) post‐operative period. This study was conducted with 16 patients with benign prostatic hyperplasia and 16 healthy subjects. Serum malondialdehyde, blood 8‐hydroxy‐2′‐deoxyguanosine/deoxyguanosine, erythrocyte superoxide dismutase, serum total coenzyme Q10 and coenzyme Q10 levels were measured. Independent samples t test was used to analyse the differences between control group and patients, while paired t test was used to analyse the differences between pre‐operative and post‐operative periods. Malondialdehyde and total coenzyme Q10 levels were lower in patients, while 8‐hydroxy‐2′‐deoxyguanosine/deoxyguanosine level was increased. However, superoxide dismutase activity and coenzyme Q10 levels did not differ. After 60 days of operation, 8‐hydroxy‐2′‐deoxyguanosine/deoxyguanosine and superoxide dismutase activity decreased, while total coenzyme Q10 level increased. However, malondialdehyde and coenzyme Q10 levels were not affected. The international prostate symptom scores of the patients were also decreased after the operation. The results suggest that blood 8‐hydroxy‐2′‐deoxyguanosine/deoxyguanosine level may reflect the oxidative stress better than the malondialdehyde level, and surgical operation attenuates the oxidative stress in late post‐operative period in benign prostatic hyperplasia patients.

Exploration of diagnostic biomarkers, microenvironment characteristics, and ursolic acid's therapeutic effect for benign prostate hyperplasia

“…The oxidative stress in BPH patients has been assessed for evaluating the effects of the operation. The results suggested that the oxidative stress can be better reflected by blood level of 8-hydroxy-2'-deoxyguanosine/deoxyguanosine level compared to that of the malondialdehyde, and surgical operation attenuated the oxidative stress in the late postoperative period in BPH patients [21]. The combination of GC-MS based metabolomics and machine learning revealed that three metabolites could be promising indicators for distinguishing prostate cancer from BPH, which were L-serine, myo-inositol, and decanoic acid [22].…”

Effect of precise nursing service mode on postoperative urinary incontinence prevention in patients with prostate disease

“…This was to help them improve urinary continence ability, to promote local blood circulation, accelerate the damage of nerve repair which can help patients recover automatic micturition function as soon as possible, and accelerate the removal of catheters. The removal of the urethra is more conducive to the early cessation of the patient's rehabilitation, which can promote the faster recovery of intestinal function[ 15 ].…”

Phloretin Ameliorates Testosterone-Induced Benign Prostatic Hyperplasia in Rats by Regulating the Inflammatory Response, Oxidative Stress and Apoptosis

“…This process possibly contributes to hyperplasia as well. In real-world practice, chronic inflammation was associated with worse symptoms [ 7 ], and OS was significantly decreased 60 days after prostatectomy to BPH [ 8 ].…”