Oxidative stress biomarkers in fetal growth restriction with and without preeclampsia

Schoots, Mirthe H.; Bourgonje, Martin F.; Bourgonje, Arno R.; Prins, Jelmer R.; Hoorn, Eline G M van; Abdulle, Amaal Eman; Kobold, Anneke Muller; Heide, Martin van der; Hillebrands, Jan-Luuk; Goor, Harry van; Gordijn, Sanne J.

doi:10.1016/j.placenta.2021.09.013

Cited by 26 publications

(18 citation statements)

References 57 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In our study, no difference was found in terms of IMA levels in maternal blood and cord blood (p=0.522 and 0.899). In a study grouped according to the presence of PE in patients with fetal growth retardation, IMA levels were found to be significantly higher in the PE group [17]. We believe that the difference in the results arose in our study because the patients were not classified according to fetal growth retardation in our study.…”

Section: Resultscontrasting

confidence: 57%

Comparison of IMA, YKL-40, EN-RAGE, and AIM levels in maternal blood and cord blood in patients with preeclampsia

Fındık¹,

İçen²,

Tunç³

et al. 2023

j-ebr

View full text Add to dashboard Cite

Preeclampsia and severe preeclampsia are among the most significant causes of maternal mortality. Preeclampsia's pathogenesis is not fully understood, and it is a disease with early diagnosis and treatment possibilities. In this study, we aimed to investigate the levels of IMA, YKL-40, EN-RAGE, and AIM in maternal and cord blood. The results will ideally shed light on preeclampsia's pathogenesis and early diagnosis. Methods: The study was conducted with the following three groups: a severe preeclampsia group (group 1), a preeclampsia group (group 2), and a control group (group 3). IMA, YKL-40, EN-RAGE, and AIM levels were measured in all patients across the groups using blood taken from the mothers before delivery and from the cords during delivery. Statistically descriptive analyses were performed. Specifically, a one-way analysis of variance was performed on group variables, and a Tukey test was used to determine the differences between the groups. Results: The mean age was similar across all groups. The gestational week at delivery was low for the severe preeclampsia group (p=0.001). The IMA and YKL-40 levels in the maternal and cord blood were the same between the groups. The EN-RAGE levels in the maternal blood were found to be significantly higher in the control group (p=0.000). While the AIM levels in the maternal blood were high in the control group (p=0.001), they were significantly lower in the cord blood in the control group (p=0.029). Conclusion: EN-RAGE and AIM levels are parameters that can be used in the early diagnosis of preeclampsia and severe preeclampsia.

show abstract

Section: Resultscontrasting

confidence: 57%

Comparison of IMA, YKL-40, EN-RAGE, and AIM levels in maternal blood and cord blood in patients with preeclampsia

Fındık¹,

İçen²,

Tunç³

et al. 2023

j-ebr

View full text Add to dashboard Cite

show abstract

“…However, both older and recent cohorts repeatedly demonstrate that leptin levels are elevated in preeclamptic patients compared with normotensive healthy pregnant patients [45–48]. Leptin levels also positively correlate with preeclampsia severity [49] and negatively with fetal weight [50,51] in preeclamptic patients. Although high BMI/obesity elevates leptin in pregnancy [52], preeclampsia patients demonstrate increases in plasma leptin levels that are disassociated with BMI [53,54,55 ▪ ].…”

Section: Leptin In Endothelial Dysfunction Of Preeclampsiamentioning

confidence: 99%

Mechanisms of leptin-induced endothelial dysfunction

Mellott¹,

Faulkner

2022

Current Opinion in Nephrology &Amp; Hypertension

View full text Add to dashboard Cite

Purpose of reviewEndothelial dysfunction is a major risk factor for many cardiovascular diseases, notably hypertension. Obesity increases the risk of endothelial dysfunction in association with increasing production of the adipokine leptin. Preclinical studies have begun to unravel the mechanisms whereby leptin leads to the development of endothelial dysfunction, which are sex-specific. This review will summarize recent findings of mechanisms of leptin-induced endothelial impairment in both male and females and in pregnancy.Recent findingsLeptin receptors are found in high concentrations in the central nervous system (CNS), via which leptin promotes appetite suppression and upregulates sympathetic nervous system activation. However, leptin receptors are expressed in many other tissues, including the vascular endothelial cells and smooth muscle cells. Recent studies in mice with vascular endothelial or smooth muscle-specific knockdown demonstrate that endothelial leptin receptor activation plays a protective role against endothelial dysfunction in male animals, but not necessarily in females. Clinical studies indicate that women may be more sensitive to obesity-associated vascular endothelial dysfunction. Emerging preclinical data indicates that leptin and progesterone increase aldosterone production and endothelial mineralocorticoid receptor activation, respectively. Furthermore, decades of clinical studies indicate that leptin levels increase in the hypertensive pregnancy disorder preeclampsia, which is characterized by systemic endothelial dysfunction. Leptin infusion in mice induces the clinical characteristics of preeclampsia, including endothelial dysfunction.SummaryNovel preclinical data indicate that the mechanisms whereby leptin promotes endothelial dysfunction are sex-specific. Leptin-induced endothelial dysfunction may also play a role in hypertensive pregnancy as well.

show abstract

“…The research by Schoots showed that the slow growth rate (estimated body mass over 30% on the growth curve compared with previous growth) was associated with the abnormal cerebroplacental blood flow ratio (the ratio of the pulsatile index of the middle cerebral artery to the umbilical artery), but with low predictive value. Recent retrospective research showed that the slow fetal growth rate was associated with the abnormal blood flow spectrum of the umbilical artery and middle cerebral artery but was not an independent influencing factor of adverse pregnancy outcomes [ 7 ]. The research by Chen showed that the late FGR with the abnormal uterine artery blood flow spectrum had a two-fold increased risk of abnormal cerebral blood flow before the delivery [ 8 ].…”

Section: Literature Reviewmentioning

confidence: 99%

[Retracted] Analysis of Causes and Results of Fetal Growth in Utero Caused by Genetic Factors Detected by Ultrasound

Liu

Wang

2022

Contrast Media & Molecular Imaging

View full text Add to dashboard Cite

In order to investigate the value of the ultrasonic monitoring of maternal and fetal vascular parameters, serum vitamin D, and placental growth factor (PLGF) in predicting fetal growth restriction (FGR), a method of ultrasonic detection of genetic factors causing fetal growth in utero was proposed. 125 pregnant women with FGR diagnosed in our hospital from June 2018 to June 2021 (the FGR group) and 125 pregnant women with a normal prenatal examination (the control group) were collected retrospectively. The systolic/diastolic blood flow ratio (S/D), pulsatile index (PI), and resistance index (RI) of the fetal umbilical artery (UA), middle cerebral artery (MCA), and maternal uterine artery (UtA) were monitored by ultrasound at 20 to 24 weeks of gestation, and the levels of serum vitamin D and PLGF were detected. The receiver operating characteristic curve (ROC curve) was used to evaluate the predictive value of FGR. The results showed that the S/D, PI, and RI of UA in the FGR group were higher than those in the control group, the areas under the curve (AUC) were 0.866, 0.817, and 0.849, and the sensitivity and specificity were (72.8%, 91.2%), (50.4%, 100%), and (72.8%, 91.2%), respectively. The S/D, PI, and RI of MCA were lower than those of the control group. The AUC was 0.882, 0.869, and 0.834, respectively; the sensitivity and specificity were (92.0%, 74.4%), (88.8%, 81.6%), and (90.4%, 72%), respectively. The S/D, PI, and RI of UtA were higher than those of the control group; the AUC was 0.768, 0.729, and 0.732; the sensitivity and specificity were (91.2%, 52%), (48%, 90.4%), and (48.8%, 90.4%), respectively. The serum levels of vitamin D and PLGF were lower than those of the control group (AUC 0.784 and 0.807), and the sensitivity and specificity were (54.4%, 91.2%) and (99.2%, 52%), respectively. It was concluded that the ultrasound monitoring of UA, MCA, and UtA in pregnant women in the middle of pregnancy and detection of serum vitamin D and PLGF levels had a certain predictive value for FGR. Moreover, the comprehensive evaluation could reduce the occurrence of FGR in high-risk pregnant women.

show abstract

Oxidative stress biomarkers in fetal growth restriction with and without preeclampsia

Cited by 26 publications

References 57 publications

Comparison of IMA, YKL-40, EN-RAGE, and AIM levels in maternal blood and cord blood in patients with preeclampsia

Comparison of IMA, YKL-40, EN-RAGE, and AIM levels in maternal blood and cord blood in patients with preeclampsia

Mechanisms of leptin-induced endothelial dysfunction

[Retracted] Analysis of Causes and Results of Fetal Growth in Utero Caused by Genetic Factors Detected by Ultrasound

Contact Info

Product

Resources

About