Oxidative Stress Biomarkers in Mexican Subjects with Overweight and Obesity: A Systematic Review

Gutiérrez-Solís, Ana Ligia; Garrido-Dzib, Angel Gabriel; Rochel-Pérez, Andrea; Magallón-Zertuche, Valeria; Chávez-Loría, Geovanni; Medina‐Vera, Isabel; Ávila-Nava, Azalia

doi:10.1089/met.2023.0001

Cited by 5 publications

(2 citation statements)

References 34 publications

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“…Similarly, a previous research demonstrated that the effect of PM 10 on hs-CRP was more evident in non-obese individuals [ 47 ]. The explanation for this observation could be that the people with obesity or overweight had slightly higher baseline of oxidative stress and inflammation, rendering the effects of air pollution in these people difficult to identify [ 48 ]. Both air pollutants and cigarettes have been reported to induce acute epithelial injury and neutrophil inflammation [ 49 , 50 ].…”

Section: Discussionmentioning

confidence: 99%

Short-term exposure to air pollution on peripheral white blood cells and inflammation biomarkers: a cross-sectional study on rural residents

Yang,

Wu,

Zeng

et al. 2024

BMC Public Health

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Effects of short-term exposure to ambient air pollution on systemic immunological and inflammatory biomarkers in rural population have not been adequately characterized. From May to July 2021, 5816 participants in rural villages of northern Henan Province, China, participated in this cross-sectional study. Blood biomarkers of systemic inflammation were determined including peripheral white blood cells (WBC), eosinophils (EOS), basophils (BAS), monocytes (MON), lymphocytes (LYM), neutrophils (NEU), neutrophil-lymphocyte ratio (NLR), and serum high-sensitivity C-reactive protein (hs-CRP). The concentrations of ambient fine particulate matter (PM2.5), PM10, nitrogen dioxide (NO2), carbon monoxide (CO), and ozone (O3) were assessed up to 7 days prior to the blood draw. A generalized linear model was used to analyze the associations between air pollution exposure and the above-mentioned blood biomarkers. Significantly positive associations were revealed between PM2.5, CO and WBC; CO, O3 and LYM; PM2.5, PM10, SO2, CO and NEU; PM2.5, PM10, SO2, CO and NLR; PM2.5, PM10, SO2, NO2, CO, O3 and hs-CRP. Meanwhile, negative associations were found between SO2 and WBC; PM2.5, PM10, NO2, CO, or O3 and EOS; PM2.5, SO2, or CO and BAS; SO2, NO2 or O3 and MON; PM2.5, PM10, SO2, or NO2 and LYM. Moreover, men, individuals with normal body mass index (BMI), current smokers, and those older than 60 years were found vulnerable to air pollution effects. Taken together, short-term exposure to air pollution was associated with systemic inflammatory responses, providing insight into the potential mechanisms for air pollution-induced detrimental systemic effects in rural residents.

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Section: Discussionmentioning

confidence: 99%

Short-term exposure to air pollution on peripheral white blood cells and inflammation biomarkers: a cross-sectional study on rural residents

Yang,

Wu,

Zeng

et al. 2024

BMC Public Health

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“…In one study, the levels of serum markers of oxidative stress, including hydrogen peroxide and malondialdehyde, in obese individuals almost doubled compared with those in individuals of normal weight (mean age, 71.0±5.7) ( 59 ). Oxidized low-density lipoprotein is an oxidative stress biomarker that is involved in the negative effects of obesity ( 60 ). Mitochondrial dysfunction is the main cause of obesity-induced oxidative stress ( 61 ).…”

Section: Hyperlipemia-induced Pathological Changes and Osteoporosismentioning

confidence: 99%

Obesity and lipid metabolism in the development of osteoporosis (Review)

Wang,

Zhang,

Zhao

et al. 2024

Int J Mol Med

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Osteoporosis is a common bone metabolic disease that causes a heavy social burden and seriously threatens life. Improving osteogenic capacity is necessary to correct bone mass loss in the treatment of osteoporosis. Osteoblasts are derived from the differentiation of bone marrow mesenchymal stem cells, a process that opposes adipogenic differentiation. The peroxisome proliferator-activated receptor γ and Wnt/β-catenin signaling pathways mediate the mutual regulation of osteogenesis and adipogenesis. Lipid substances play an important role in the occurrence and development of osteoporosis. The content and proportion of lipids modulate the activity of immunocytes, mainly macrophages, and the secretion of inflammatory factors, such as IL-1, IL-6 and TNF-α. These inflammatory effectors increase the activity and promote the differentiation of osteoclasts, which leads to bone imbalance and stronger bone resorption. Obesity also decreases the activity of antioxidases and leads to oxidative stress, thereby inhibiting osteogenesis. The present review starts by examining the bidirectional differentiation of BM-MScs, describes in detail the mechanism by which lipids affect bone metabolism, and discusses the regulatory role of inflammation and oxidative stress in this process. The review concludes that a reasonable adjustment of the content and proportion of lipids, and the alleviation of inflammatory storms and oxidative damage induced by lipid imbalances, will improve bone mass and treat osteoporosis. Contents1. Introduction 2. Obesity-induced osteoporosis 3. Balance of osteogenesis and adipogenesis 4. Hyperlipemia-induced pathological changes and osteoporosis 5. Lipids and osteoporosis 6. Obesity in postmenopausal osteoporosis 7. Lipid metabolism disorders in osteoporotic patients with diabetes 8. discussion

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Oxidative stress disrupts vascular microenvironmental homeostasis affecting the development of atherosclerosis

Shao,

Chen,

Zheng

et al. 2024

Cell Biology International

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Atherosclerosis is primarily an inflammatory reaction of the cardiovascular system caused by endothelial damage, leading to progressive thickening and hardening of the vessel walls, as well as extensive necrosis and fibrosis of the surrounding tissues, the most necessary pathological process causing cardiovascular disease. When the body responds to harmful internal and external stimuli, excess oxygen free radicals are produced causing oxidative stress to occur in cells and tissues. Simultaneously, the activation of inflammatory immunological processes is followed by an elevation in oxygen free radicals, which directly initiates the release of cytokines and chemokines, resulting in a detrimental cycle of vascular homeostasis abnormalities. Oxidative stress contributes to the harm inflicted upon vascular endothelial cells and the decrease in nitric oxide levels. Nitric oxide is crucial for maintaining vascular homeostasis and is implicated in the development of atherosclerosis. This study examines the influence of oxidative stress on the formation of atherosclerosis, which is facilitated by the vascular milieu. It also provides an overview of the pertinent targets and pharmaceutical approaches for treating this condition.

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Oxidative Stress Biomarkers in Mexican Subjects with Overweight and Obesity: A Systematic Review

Cited by 5 publications

References 34 publications

Short-term exposure to air pollution on peripheral white blood cells and inflammation biomarkers: a cross-sectional study on rural residents

Short-term exposure to air pollution on peripheral white blood cells and inflammation biomarkers: a cross-sectional study on rural residents

Obesity and lipid metabolism in the development of osteoporosis (Review)

Oxidative stress disrupts vascular microenvironmental homeostasis affecting the development of atherosclerosis

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