Oxidative stress by inorganic arsenic: modulation by thyroid hormones in rat

Allen, Tanu; Rana, S. V. S.

doi:10.1016/s1532-0456(03)00086-3

Cited by 24 publications

(21 citation statements)

References 25 publications

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“…It is positively associated with TSH level for experimental group but negatively associated for control group, with FT 4 it is negatively associated for both experimental and control groups; it is also negatively correlated with radioiodine uptake levels at 2 hours and 24 hours for both experimental and control groups. From the t-test results, it has been found that the relationships of urinary arsenic level with urinary iodine, TSH , FT 4 and radiiodine uptake levels at 2 hours were not statistically significant for both experimental and control groups, but the relationship with radioiodine uptake level at 24 hours for experimental group was statististically significant at any level of significance, but for control group it was statistically significant at 10% level of significance. Table 2 it has been found that 6.67% patients fall below normal level, 40% patients fall within normal level and 53.33% patients fall above normal level of arsenic for the experimental group but for control group 92.5% patients fall within normal level and 7.5% patients fall above normal level of arsenic for the control group.…”

Section: Resultsmentioning

confidence: 93%

“…The median values of radioiodine uptake level at 2 hours and 24 hours for experimental and control groups are not significantly different but their range are different. From Mann-Whitney U-test results or results of the standard normal test, it can be concluded that the arsenic level, FT 4 and radioiodine uptake levels at 2 hours between experimental and control groups are significantly different but the urinary iodine level, TSH levels and radioiodine uptake levels at 24 hours between experimental and control groups are not statistically different. Thus, from the Mann-Whitney U-test results it can also be concluded that the iodine deficiency is not the only factor of causing simple diffuse goiter, but arsenic level is also another most important factor of causing simple diffuse goiter in Bangladeshi population.…”

Section: Resultsmentioning

confidence: 95%

“…This was a case-control analytical study. In this study, we used the variables urinary iodine, urinary arsenic, TSH, FT 4 and radioiodine uptake for both experimental group with simple diffuse goiter and control group.…”

Section: Methodsmentioning

confidence: 99%

“…10(1): 13-20, 2011 (June) of unknown at present inhibit arsenic accumulation in liver and kidney. 4 There are some postulated mechanisms of arsenic affecting the thyroid gland. One of those is arsenic reduces thyroid uptake of iodine.…”

Section: Introductionmentioning

confidence: 99%

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Relationship between Urinary Arsenic Level and Urinary Iodine, Radioiodine Uptake, TSH, FT4 Levels: Research is Based on Experimental and Control Groups

Hossain

Begum

2012

Dhaka Univ. J. Pharm. Sci

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ABSTRACT:In Bangladesh drinking water is heavily contaminated with arsenic. An estimated 50 million people are at risk from drinking of arsenic contaminated water in Bangladesh and West Bengal in India. Millions of people in many districts of Bangladesh are drinking ground water with arsenic concentrations above acceptable levels (0.05 mg/l) and many of them have already been diagnosed with poisoning symptoms. That is why, in this research an attempt has been made to find the relation between arsenic levels and urinary iodine, radioiodine uptake, thyroid stimulating hormone (TSH) and free thyroxin (FT 4 ) levels in Bangladeshi population. Another purpose has also been made to find the impacts of arsenic level on simple diffuse goiters. This is a case-control analytic study. The study was carried out at the Institute of Nuclear Medicine and Ultrasound, in collaboration with the thyroid out patient department of Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh. From our analytical results it has been found that, only the variable radioiodine uptake at 24 hours play significant role for reducing the arsenic level. Also, it has been found that iodine deficiency is not only the factor of causing simple diffuse goiter, but arsenic level is also one of the most important factors of causing simple diffuse goiter in Bangladeshi population.

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Section: Resultsmentioning

confidence: 93%

Section: Resultsmentioning

confidence: 95%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Relationship between Urinary Arsenic Level and Urinary Iodine, Radioiodine Uptake, TSH, FT4 Levels: Research is Based on Experimental and Control Groups

Hossain

Begum

2012

Dhaka Univ. J. Pharm. Sci

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“…These differences have been attributed to the influence of oestrogenic or androgenic hormones on drug-metabolising enzymes (1). Endocrinal disturbances may greatly alter the toxic potential of drugs or other xenobiotics (2)(3)(4). Removal of endocrine glands or conditions induced to reduce their activity may also affect drug metabolism.…”

mentioning

confidence: 99%

Effects of Progesterone on Benzene Toxicity in Rats

Verma¹,

Rana²

2008

Archives of Industrial Hygiene and Toxicology

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Benzene is a frequently used industrial solvent. Its toxic manifestations could be modified by sex hormones, but mechanisms of their action are poorly understood. We have examined the influence of progesterone on lipid peroxidation (malondialdehyde), reduced glutathione (GSH), and cytochrome P450 2E1 (CYP2E1) in the liver and kidneys of female rats. Progesterone applied to benzene-treated rats inhibited the formation of reactive oxygen species (ROS), but in ovariectomised benzene-treated rats it significantly increased GSH in the liver. No improvement in CYP2E1 activity was observed in progesterone treated rats. Our results evidence that progesterone changes benzene toxicity (generation of ROS, oxidative stress). However, the probable antioxidative effect of progesterone needs to be confirmed by further studies.

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Analysis of genomic dose‐response information on arsenic to inform key events in a mode of action for carcinogenicity

Gentry

McDonald

Sullivan

et al. 2009

Environ and Mol Mutagen

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A comprehensive literature search was conducted to identify information on gene expression changes following exposures to inorganic arsenic compounds. This information was organized by compound, exposure, dose/concentration, species, tissue, and cell type. A concentration-related hierarchy of responses was observed, beginning with changes in gene/protein expression associated with adaptive responses (e.g., preinflammatory responses, delay of apoptosis). Between 0.1 and 10 microM, additional gene/protein expression changes related to oxidative stress, proteotoxicity, inflammation, and proliferative signaling occur along with those related to DNA repair, cell cycle G2/M checkpoint control, and induction of apoptosis. At higher concentrations (10-100 microM), changes in apoptotic genes dominate. Comparisons of primary cell results with those obtained from immortalized or tumor-derived cell lines were also evaluated to determine the extent to which similar responses are observed across cell lines. Although immortalized cells appear to respond similarly to primary cells, caution must be exercised in using gene expression data from tumor-derived cell lines, where inactivation or overexpression of key genes (e.g., p53, Bcl-2) may lead to altered genomic responses. Data from acute in vivo exposures are of limited value for evaluating the dose-response for gene expression, because of the transient, variable, and uncertain nature of tissue exposure in these studies. The available in vitro gene expression data, together with information on the metabolism and protein binding of arsenic compounds, provide evidence of a mode of action for inorganic arsenic carcinogenicity involving interactions with critical proteins, such as those involved in DNA repair, overlaid against a background of chemical stress, including proteotoxicity and depletion of nonprotein sulfhydryls. The inhibition of DNA repair under conditions of toxicity and proliferative pressure may compromise the ability of cells to maintain the integrity of their DNA.

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Oxidative stress by inorganic arsenic: modulation by thyroid hormones in rat

Cited by 24 publications

References 25 publications

Relationship between Urinary Arsenic Level and Urinary Iodine, Radioiodine Uptake, TSH, FT4 Levels: Research is Based on Experimental and Control Groups

Relationship between Urinary Arsenic Level and Urinary Iodine, Radioiodine Uptake, TSH, FT4 Levels: Research is Based on Experimental and Control Groups

Effects of Progesterone on Benzene Toxicity in Rats

Analysis of genomic dose‐response information on arsenic to inform key events in a mode of action for carcinogenicity

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