Oxidative Stress by Tartrazine in the Testis of Wistar Rats

Visweswaran, B.

doi:10.9790/3008-0234447

Cited by 27 publications

(20 citation statements)

References 33 publications

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“…Zn derived from testis tissues that were damaged by irradiation could be accumulated in other organ. This result is in harmony with that of Visweswaran and Krishnamoorthy (2012), who reported that Zn, a remarkable antioxidant, is an essential component of many metalloenzymes, its deficiency results in oxidative stress. On the other hand, γ-irradiation induced significant increase in testicular-Cu content.…”

Section: Discussionsupporting

confidence: 76%

“…They play important roles in the catalytic and antioxidant activities of major enzymes. Also, deficiency of these trace elements (Zn & Cu) has been implicated with infertility (Nada et al, 2011 andVisweswaran andKrishnamoorthy, 2012). In the current study, γ-irradiation of rats induced decrease in testicular-Zn content.…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, the presence of Zn at the cellular level is essential for the cell growth and division in gonads, which occurs continuously. So that, Zndeficiency causes testicular atrophy, reductions in libido and sperm production, atrophy of seminiferous tubules and complete inhibition of spermatogenesis (Visweswaran and Krishnamoorthy, 2012).…”

mentioning

confidence: 99%

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The Potential Therapeutic Effect of Ferulic Acid in Mitigating Oxidative Stress Induced by γ-Irradiation in Male Rats

2016

Egypt. J. Rad.Sci.

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HE TESTIS is considered as one of the most sensitive organs in the body to ionizing radiation because of the rapidly dividing germinal epithelium. Seminal oxidative stress (OS) causes damage of the sperm plasma membrane and loss of its DNA integrity, therefore, the need for an effective therapeutic agent is evident. The present study investigated the mechanism(s) of potential therapeutic effect of ferulic acid (FA) on radiation-induced testicular damage.Mature male albino rats were either exposed to single dose γ-radiation (5Gy) and/ or treated with FA (50mg/ kg body wt, orally), daily for seven days post-irradiation. FA significantly reversed OS effects of γ-rays that was evidenced by increasing malondialdehyde (MDA) and decreasing ferric reducing antioxidant power (FRAP) and catalase (CAT) activity. In addition, alterations in some trace elements such as zinc (Zn), cupper (Cu), iron (Fe) and manganese (Mn) were observed. Furthermore, sperm head abnormalities noticeably increased in the γ-irradiated group; in contrast, FA treatment ameliorated these alterations.In conclusion, FA exhibited curative effect against radiation induced testicular damage.

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Section: Discussionsupporting

confidence: 76%

Section: Discussionmentioning

confidence: 99%

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The Potential Therapeutic Effect of Ferulic Acid in Mitigating Oxidative Stress Induced by γ-Irradiation in Male Rats

2016

Egypt. J. Rad.Sci.

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“…Tartrazine administration for 60 days to male rats reduced testicular concentrations of superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase (Visweswaran and Krishnamoorthy 2012). These synthetic colorants can alter concentrations of zinc, iron, copper and manganese which are all essential cofactors for antioxidant enzymes (Cemek et al 2014;Visweswaran and Krishnamoorthy 2012). Food colourings are also associated with increased immune reactivity which may be another mechanism associated with O&NS (Vojdani and Vojdani 2015).…”

Section: Potential Causes Of Oandns In Adhdmentioning

confidence: 99%

“…In an animal study, the administration of several synthetic food colorants and flavour additives lowered blood and liver concentrations of reduced glutathione, glutathione-Stransferase and superoxide dismutase (El-Wahab and Moram 2013). Tartrazine administration for 60 days to male rats reduced testicular concentrations of superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase (Visweswaran and Krishnamoorthy 2012). These synthetic colorants can alter concentrations of zinc, iron, copper and manganese which are all essential cofactors for antioxidant enzymes (Cemek et al 2014;Visweswaran and Krishnamoorthy 2012).…”

Section: Potential Causes Of Oandns In Adhdmentioning

confidence: 99%

Oxidative and nitrosative stress in ADHD: possible causes and the potential of antioxidant-targeted therapies

Lopresti

2015

ADHD Atten Def Hyp Disord

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Attention deficit hyperactivity disorder (ADHD) has a complex etiology although theories associated with disturbances in dopaminergic and noradrenergic activity are most commonly cited.The importance of these catecholamines in ADHD is supported by its effective treatment utilising stimulant and non-stimulant medications that modify their activity. Recently there has been interest in oxidative and nitrosative stress (O&NS) in ADHD and its potential to contribute to this condition. In this article, research investigating O&NS in ADHD is reviewed and its impact on catecholaminergic activity and neurological structure is discussed. Lifestyle, environmental, ADHD is most commonly treated with stimulant medications such as methylphenidate and amphetamines, non-stimulants such as atomoxetine, and alpha2-adrenergic agonists such as clonidine and guanfacine. Through their effects on dopamine and noradrenaline transporters, stimulants inhibit the reuptake of dopamine and noradrenaline, thereby increasing the extracellular levels of these neurotransmitters. These stimulants also inhibit monoamine oxidase, the enzyme that metabolises these catecholamines (Wilens et al. 2011). Atomoxetine works as a selective reuptake inhibitor of noradrenaline leading to its increased extracellular concentration (Garnock- Jones and Keating 2009).While effective, these medications are associated with several adverse effects. These include loss of appetite, growth delay and sleep disturbances (Cortese et al. 2013). It is important to note that despite their widely accepted short-term efficacy, the long-term effectiveness of pharmacological treatments on social, educational and occupational functioning in people with ADHD continues to be debated (Huang and Tsai 2011;Langberg and Becker 2012;Nijmeijer et al. 2008). On a positive note, recent analyses using the Swedish national registrar suggests that long-term stimulant use in people with ADHD is associated with reduced rates of substance use, criminality, and serious traffic accidents (Chang et al. 2014a;Chang et al. 2014b;Lichtenstein et al. 2012).Despite wide appreciation of catecholaminergic theories associated with ADHD, there has been increased research into other biological mechanisms associated with ADHD. For example, in psychiatry there has been interest in immune-inflammatory pathways and oxidative and nitrosative stress (O&NS). In particular, it has been confirmed through recent meta-analyses that depression is Increased O&NS has also been found in bipolar disorder (Andreazza et al. 2008;Brown et al. 2014),

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Evaluation of the effect of tartrazine on the offspring rats in an in vivo experimental model

Öztürk,

Dikici,

Gür

et al. 2024

Food Science & Nutrition

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Tartrazine, an azo dye prevalent in pharmaceuticals and food items, was investigated for its impact on fetal development, specifically examining visceral and skeletal abnormalities in rat offspring exposed to daily oral doses throughout pregnancy. Fourteen pregnant rats were randomly assigned to control and tartrazine groups (seven animals each), with tartrazine administered via oral gavage at 7.5 mg/kg throughout gestation. Offspring were categorized by gender for histopathological and genetic analysis of visceral structures. Bone quality and fracture resistance assessments involved micro‐CT, Raman spectroscopy, and biomechanical testing. Results highlighted distinct internal organ tissue differences in the tartrazine group, notably increased hemorrhagic and inflammatory cell infiltration, degeneration, and vacuolization compared to controls. Gender‐specific alterations in mRNA levels of IL‐6, IL‐1β, TNF‐α, and TRPM2 genes (p < .001) were also noted. Moreover, tartrazine‐exposed groups exhibited reduced trabecular thickness, bone volume, and significant alterations in bone matrix composition and quality alongside significant decreases in fracture resistance (p < 0.05). This study concludes that intrauterine exposure to tartrazine can result in adverse impacts on organ and bone development in rat offspring.

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Oxidative Stress by Tartrazine in the Testis of Wistar Rats

Abstract: :The aim is to study the effect of Tartrazine (E102)

Cited by 27 publications

References 33 publications

The Potential Therapeutic Effect of Ferulic Acid in Mitigating Oxidative Stress Induced by γ-Irradiation in Male Rats

The Potential Therapeutic Effect of Ferulic Acid in Mitigating Oxidative Stress Induced by γ-Irradiation in Male Rats

Oxidative and nitrosative stress in ADHD: possible causes and the potential of antioxidant-targeted therapies

Evaluation of the effect of tartrazine on the offspring rats in an in vivo experimental model

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