Oxidative stress – chronic kidney disease – cardiovascular disease: A vicious circle

Ravarotto, Verdiana; Simioni, Francesca; Pagnin, Elisa; Davis, Paul A.; Calò, Lorenzo A.

doi:10.1016/j.lfs.2018.08.067

Cited by 97 publications

(101 citation statements)

References 70 publications

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“…It has been widely acknowledged that patients with chronic kidney disease, especially end‐stage renal disease (ESRD), suffer from the increasing burden of cardiovascular diseases. A higher incidence of coronary artery disease and sudden death, as well as major adverse cardiovascular events, was observed in this population, which might be partially attributed to their vicious interactions between oxidative stress, inflammatory process and endothelial dysfunction. Results from a meta‐analysis that enrolled 105,872 participants from 14 studies showed that reduced estimated glomerular filtration rate and elevated urine albumin‐to‐creatinine ratio were correlated with higher all‐cause mortality.…”

Section: Introductionmentioning

confidence: 86%

Diabetes attenuated age‐related aortic root dilatation in end‐stage renal disease patients receiving peritoneal dialysis

Zhang

et al. 2019

J of Diabetes Invest

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Aims/Introduction Recently, some data have supported the concept that diabetes is negatively associated with aortic aneurysm. In the present study, we aimed to investigate the relationship between diabetes and cardiac structural and functional characteristics, in particular, aortic root dimensions, in end‐stage renal disease (ESRD) patients. Methods ESRD patients receiving peritoneal dialysis for >3 months were consecutively enrolled. Clinical features and echocardiographic parameters were analyzed according to the presence of diabetes history. Correlation analyses were carried out for diabetes mellitus and aortic root dilatation. Multiple logistic regression analysis was carried out to identify variables correlated with aortic root dilatation. Results A total of 218 ESRD patients receiving peritoneal dialysis were enrolled. Patients with diabetes showed lower left ventricular internal measurements in end‐diastole, left ventricular internal measurements in end‐systole and aortic root diameter (ARD)/body surface area (BSA). Worse cardiac diastolic function was also observed in these patients. In addition, the age‐related increase of ARD/BSA and ARD/height was attenuated in patients with diabetes. With the increase of ARD/BSA, lower levels of serum creatinine, phosphorus and serum glucose, as well as higher serum high‐density lipoprotein cholesterol and apolipoprotein A‐1 were also observed. Increased normalized left ventricular internal measurements were shown in patients with greater ARD/BSA. Multiple regression analysis showed that diabetes (odds ratio 0.353, P = 0.015) was an independent correlate of aortic root dilatation, even after correction for age, sex and other clinical confounders in the enrolled patients. Conclusions The present findings shown an inverse association between diabetes and age‐related aortic root dilatation in ESRD patients. Diabetes remained to be independently correlated with aortic root dilatation even after adjustment for age, sex and other clinical confounders in ESRD patients.

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Section: Introductionmentioning

confidence: 86%

Diabetes attenuated age‐related aortic root dilatation in end‐stage renal disease patients receiving peritoneal dialysis

Zhang

et al. 2019

J of Diabetes Invest

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“…Patients with CKD show increased oxidative stress on the basis of an over-production of ROS, as well as decreased anti-oxidant defenses [29,114]. In general, ROS are generated from the reduction of oxygen and can induce oxidation of important macromolecules, including proteins, lipids, carbohydrates, and DNA [29,114], thereby exerting toxic effects on mitochondria [115]. Thus, sufficient anti-oxidative mechanisms are necessary to counteract the excessive ROS formation in cells.…”

Section: Mitochondrial Dysfunction/oxidative Stress and Premature Agementioning

confidence: 99%

Inflammation and Premature Ageing in Chronic Kidney Disease

Ebert

Pawelzik

Witasp

et al. 2020

Toxins

162

122

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Persistent low-grade inflammation and premature ageing are hallmarks of the uremic phenotype and contribute to impaired health status, reduced quality of life, and premature mortality in chronic kidney disease (CKD). Because there is a huge global burden of disease due to CKD, treatment strategies targeting inflammation and premature ageing in CKD are of particular interest. Several distinct features of the uremic phenotype may represent potential treatment options to attenuate the risk of progression and poor outcome in CKD. The nuclear factor erythroid 2-related factor 2 (NRF2)–kelch-like erythroid cell-derived protein with CNC homology [ECH]-associated protein 1 (KEAP1) signaling pathway, the endocrine phosphate-fibroblast growth factor-23–klotho axis, increased cellular senescence, and impaired mitochondrial biogenesis are currently the most promising candidates, and different pharmaceutical compounds are already under evaluation. If studies in humans show beneficial effects, carefully phenotyped patients with CKD can benefit from them.

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“…End‐stage renal disease (ESRD) occurs in the last stages of CKD . Although accumulation of fluids, toxins and wastes in the body is the primary dilemma in ESRD, patients are affected by comorbidities such as cardiovascular diseases, mainly as a result of blood lipid disorders, hypertension, oxidative stress and inflammation …”

Section: Introductionmentioning

confidence: 99%

“…1 End-stage renal disease (ESRD) occurs in the last stages of CKD. 1 Although accumulation of fluids, toxins and wastes in the body is the primary dilemma in ESRD, patients are affected by comorbidities such as cardiovascular diseases, 2,3 mainly as a result of blood lipid disorders, 1,4 hypertension, 5 oxidative stress 3 and inflammation. 6 Lipid profile abnormalities in CKD generally include elevated triglycerides and reduced levels of high-density lipoprotein (HDL) cholesterol with either no remarkable change or a reduction in total cholesterol and low-density lipoprotein (LDL) cholesterol.…”

Section: Introductionmentioning

confidence: 99%

Pomegranate juice improves cardiometabolic risk factors, biomarkers of oxidative stress and inflammation in hemodialysis patients: a randomized crossover trial

et al. 2019

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BACKGROUND Pomegranate has antioxidant, cardioprotective and anti‐inflammatory properties. We designed a crossover study aimed at determining if consumption of pomegranate juice (PJ) improves lipid profile and oxidative and inflammatory biomarkers of hemodialysis patients. Forty‐one hemodialysis patients were randomly assigned to one of two groups: PJ‐treated group receiving 100 mL of natural PJ immediately after their dialysis session three times a week and the control group receiving the usual care. After 8 weeks, a 4‐week washout period was established and then the role of the groups was exchanged. Lipid profile, blood pressure and oxidative and inflammatory biomarkers were measured before and after each sequence. RESULTS Based on the results of intention‐to‐treat analysis, triglycerides were decreased in PJ condition and increased in the controls. Conversely, high‐density lipoprotein cholesterol was increased in PJ and decreased in the control group. Total and low‐density lipoprotein cholesterol did not significantly change in either condition. Systolic and diastolic blood pressure significantly decreased in PJ condition. Total antioxidant capacity increased in PJ condition (P < 0.001) and decreased in the controls (P < 0.001). Conversely, malondialdehyde and interleukin‐6 decreased in PJ (P < 0.001) and increased in the control group (P ≤ 0.001). The changes of these biomarkers were significantly different between the two conditions. CONCLUSIONS Eight‐week PJ consumption showed beneficial effects on blood pressure, serum triglycerides, high‐density lipoprotein cholesterol, oxidative stress and inflammation in hemodialysis patients. © 2019 Society of Chemical Industry

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Oxidative stress – chronic kidney disease – cardiovascular disease: A vicious circle

Cited by 97 publications

References 70 publications

Diabetes attenuated age‐related aortic root dilatation in end‐stage renal disease patients receiving peritoneal dialysis

Diabetes attenuated age‐related aortic root dilatation in end‐stage renal disease patients receiving peritoneal dialysis

Inflammation and Premature Ageing in Chronic Kidney Disease

Pomegranate juice improves cardiometabolic risk factors, biomarkers of oxidative stress and inflammation in hemodialysis patients: a randomized crossover trial

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