Oxidative stress cytotoxicity induced by platinum-doped magnesia nanoparticles in cancer cells

Al-Fahdawi, Mohamed Qasim; Al-Doghachi, Faris A. J.; Abdullah, Qasim Khlaif; Hammad, Ruaa Tareq; Abdullah, Rasedee; Ibrahim, Wisam Nabeel; Mediani, Ahmed; Alosaimi, Areej A.; Aldosary, Sahar Khamees; Eid, Eltayeb E M; Rosli, Rozita; Taufiq‐Yap, Yun Hin; Al-Haj, Nagi Ahmed Abdullah; Al‐Qubaisi, Mothanna Sadiq

doi:10.1016/j.biopha.2021.111483

Cited by 26 publications

(18 citation statements)

References 41 publications

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“…In our study, the effect of vitamin C on viability and composition of human colon cell CCD-18 Co exposed to oxidative stress was investigated, and final conclusions confirm the anti-oxidant properties of this compound. CCD-18 Co cells are human fibroblast cells used in many studies as model normal colon cells, and different compounds such as linalool [53], Pt/MgO nanoparticles [54], or L-buthionine sulfoximine (BSO) [55] were already reported to induce oxidative stress in CCD-18 Co cells. In our study, tBHP was used as an oxidative stress inducer, because this compound is also widely exploited to effectively induce oxidative stress in vitro [56,57].…”

Section: Discussionmentioning

confidence: 99%

Raman Spectroscopy and Imaging Studies of Human Digestive Tract Cells and Tissues—Impact of Vitamin C and E Supplementation

Beton

Brożek-Płuska

2022

Molecules

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Cancers of digestive tract such as colorectal cancer (CRC) and gastric cancer (GC) are the most commonly detected types of cancer worldwide and their origin can be associated with oxidative stress conditions. Commonly known and followed antioxidants, such as vitamin C and E, are widely considered as potential anti-cancer agents. Raman spectra have great potential in the biochemical characterization of matter based on the fact that each molecule has its own unique vibrational properties. Raman spectroscopy allows to precisely characterize components (proteins, lipids, nucleic acids). The paper presents the application of the Raman spectroscopy technique for the analysis of tissue samples and cells of the human colon and stomach. The main goal of this study is to show the differences between healthy and cancerous tissues from the human digestive tract and human normal and cancer colon and gastric cell lines. The paper presents the spectroscopic characterization of normal colon cells, CCD-18 Co, in physiological and oxidative conditions and effect of oxidative injury of normal colon cells upon supplementation with vitamin C at various concentrations based on Raman spectra. The obtained results were related to the Raman spectra recorded for human colon cancer cells—CaCo-2. In addition, the effect of the antioxidant in the form of vitamin E on gastric cancer cells, HTB-135, is presented and compared with normal gastric cells—CRL-7869. All measured gastric samples were biochemically and structurally characterized by means of Raman spectroscopy and imaging. Statistically assisted analysis has shown that normal, ROS injured and cancerous human gastrointestinal cells can be distinguished based on their unique vibrational properties. ANOVA tests, PCA (Principal Component Analysis) and PLSDA (Partial Least Squares Discriminant Analysis) have confirmed the main role of nucleic acids, proteins and lipids in differentiation of human colon and stomach normal and cancer tissues and cells. The conducted research based on Raman spectra proved that antioxidants in the form of vitamin C and E exhibit anti-cancer properties. In consequence, conducted studies proved that label-free Raman spectroscopy may play an important role in clinical diagnostic differentiation of human normal and cancerous gastrointestinal tissues and may be a source of intraoperative information supporting histopathological analysis.

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Section: Discussionmentioning

confidence: 99%

Raman Spectroscopy and Imaging Studies of Human Digestive Tract Cells and Tissues—Impact of Vitamin C and E Supplementation

Beton

Brożek-Płuska

2022

Molecules

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“…Moreover, nanorobots are currently designed to recognize 12 different types of cancer cells [ 80 ]. The impact of nanoparticles on various types of cancer cells, such as colon cancer [ 26 , 27 , 30 , 31 ], glioblastoma and melanoma [ 26 ], neuroblastoma [ 28 ], breast cancer [ 29 ], cervical cancer [ 29 ], lung cancer [ 34 , 37 ], prostate cancer [ 35 ], oral squamous cell cancer [ 36 ], liver cancer [ 22 ], brain cancer [ 78 ], pancreatic cancer [ 81 ], bladder cancer [ 82 ], colorectal cancer [ 83 ], and cancer stem cells [ 23 ], has been investigated. The application of other types of nanoparticles in cancer therapy is summarized in Table 10 .…”

Section: Commonly Used Nanoparticles In Cancer Diagnosismentioning

confidence: 99%

Nanotechnology in Cancer Diagnosis and Treatment

et al. 2023

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Traditional cancer diagnosis has been aided by the application of nanoparticles (NPs), which have made the process easier and faster. NPs possess exceptional properties such as a larger surface area, higher volume proportion, and better targeting capabilities. Additionally, their low toxic effect on healthy cells enhances their bioavailability and t-half by allowing them to functionally penetrate the fenestration of epithelium and tissues. These particles have attracted attention in multidisciplinary areas, making them the most promising materials in many biomedical applications, especially in the treatment and diagnosis of various diseases. Today, many drugs are presented or coated with nanoparticles for the direct targeting of tumors or diseased organs without harming normal tissues/cells. Many types of nanoparticles, such as metallic, magnetic, polymeric, metal oxide, quantum dots, graphene, fullerene, liposomes, carbon nanotubes, and dendrimers, have potential applications in cancer treatment and diagnosis. In many studies, nanoparticles have been reported to show intrinsic anticancer activity due to their antioxidant action and cause an inhibitory effect on the growth of tumors. Moreover, nanoparticles can facilitate the controlled release of drugs and increase drug release efficiency with fewer side effects. Nanomaterials such as microbubbles are used as molecular imaging agents for ultrasound imaging. This review discusses the various types of nanoparticles that are commonly used in cancer diagnosis and treatment.

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“…Platinum-based drugs trigger a ROS generation burst, resulting in the loss of mitochondrial membrane potential [113] and a decrease in the glutathione level, leading malignant cells to die by apoptosis. Platinum is a transition metallic element able to lose electrons and positively charge ions, disturbing the normal electron flow of enzymes and substrates and ultimately affecting their catalytic activity [114]. Currently, clinical trials are focused on improving the anticancer effects of FOLFOX6 and lowering the severity of side effects with adjuvants or alternatives.…”

Section: Oxaliplatinmentioning

confidence: 99%

Microenvironmental Reactive Oxygen Species in Colorectal Cancer: Involved Processes and Therapeutic Opportunities

Sorolla

Hidalgo

Sorolla

et al. 2021

Cancers

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Colorectal cancer (CRC) is the fourth most common cause of cancer deaths worldwide. Although screening programs have reduced mortality rates, there is a need for research focused on finding the main factors that lead primary CRC to progress and metastasize. During tumor progression, malignant cells modify their habitat, corrupting or transforming cells of different origins and creating the tumor microenvironment (TME). Cells forming the TME like macrophages, neutrophils, and fibroblasts generate reactive oxygen species (ROS) that modify the cancer niche. The effects of ROS in cancer are very diverse: they promote cellular proliferation, epithelial-to-mesenchymal transition (EMT), evasion of cell death programs, migration, and angiogenesis. Due to the multifaceted role of ROS in cancer cell survival and function, ROS-modulating agents such as antioxidants or pro-oxidants could have therapeutic potential in cancer prevention and/or as a complement to systemic treatments. In this review, we will examine the main ROS producer cells and their effects on cancer progression and metastasis. Furthermore, we will enumerate the latest clinical trials where pro-oxidants and antioxidants have therapeutic uses in CRC.

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Oxidative stress cytotoxicity induced by platinum-doped magnesia nanoparticles in cancer cells

Cited by 26 publications

References 41 publications

Raman Spectroscopy and Imaging Studies of Human Digestive Tract Cells and Tissues—Impact of Vitamin C and E Supplementation

Raman Spectroscopy and Imaging Studies of Human Digestive Tract Cells and Tissues—Impact of Vitamin C and E Supplementation

Nanotechnology in Cancer Diagnosis and Treatment

Microenvironmental Reactive Oxygen Species in Colorectal Cancer: Involved Processes and Therapeutic Opportunities

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