Oxidative Stress, Diabetic Retinopathy, and Superoxide Dismutase 3

Extracellular superoxide dismutase (EcSOD) is the only extracellular scavenger of superoxide anion (O 2 .-) with unique binding capacity to cell surface and extracellular matrix through its heparin-binding domain. Enhanced EcSOD activity prevents oxidative stress and damage, which are fundamental in a variety of disease pathologies. In this review we will discuss the findings in humans and animal studies supporting the benefits of EcSOD induced by exercise training in reducing oxidative stress in various tissues. In particularly, we will highlight the importance of skeletal muscle EcSOD, which is induced by endurance exercise and redistributed through the circulation to the peripheral tissues, as a molecular transducer of exercise training to confer protection against oxidative stress and damage in various disease conditions.

show abstract

“…Others too have proposed that EcSOD may be targeted a potential therapeutic to protect against oxidative stress and DR (52).…”

Section: Copdmentioning

confidence: 99%

Extracellular superoxide dismutase, a molecular transducer of health benefits of exercise

2020

View full text Add to dashboard Cite

show abstract

“…In addition, many studies have shown that MSCs regulate the expression of a variety of molecules related to immunosuppression, including COX-2, TNF-α and IFN-γ [59,60] . In an STZinduced DM rat model, Evs from AMSCs effectively down-regulate the expression of IL-1 β, IL-6 and TNFα, and alleviate in ammation and retinal injury [55] .…”

Section: Discussionmentioning

confidence: 98%

“…The protective effect of MSCs on blood vessels and nerves has been found to depend on the inhibition of oxidation and in ammation, which play fundamental roles in the pathogenesis of DR [55] . The retina is rich in unsaturated fatty acids and has a high demand for oxygen and energy, so it is particularly vulnerable to oxidative stress.…”

Section: Discussionmentioning

confidence: 99%

TBHQ Regulates the Nrf2/HO-1 Pathway to Enhance Stem Cell Treatment of Diabetic Retinopathy

Xu¹,

Tian²,

Li³

et al. 2021

Preprint

View full text Add to dashboard Cite

Objective: To investigate the therapeutic effect of human umbilical cord mesenchymal stem cells (hUCMSCs) on diabetic retinopathy (DR) in diabetic rats, and to study the mechanism of hUCMSCs in treating diabetic retinopathy by tert-butylhydroquinone (tBHQ) regulation of the Nrf2/HO-1 pathway.Methods: The diabetic rat model was induced by intraperitoneal injection of streptozotocin (STZ). The experimental animals were divided into six groups: Normal, diabetes mellitus (DM), hUCMSCs, tBHQ, combined tBHQ-hUCMSCs, and all-trans-retinoid acid (ATRA)-hUCMSCs combined group. Visual function experiments and histological analyses were performed eight weeks post intravitreal injection. Biochemical and molecular analyses were used to assess the hUCMSCs composition and its biological effects.Results: Improvements in systemic oxidative stress and inflammation were found in the tBHQ group. Although hUCMSCs had no significant effect on oxidative stress, retinal structure was improved, visual defects reduced and expression of local retinal inflammatory factors were inhibited following its application. The effect of combined therapy was better than that of single therapy. Inhibition of the Nrf2/HO-1 pathway can promote the expression of systemic inflammatory factors and inhibit the therapeutic effect of hUCMSCs in the retina.Conclusions: Intravitreal administration of hUCMSCs triggers an effective cytoprotective microenvironment in the retina of diabetic mice. Alone, however, it may not significantly improve the systemic inflammatory response of diabetes. In combination with tBHQ it may promote Nrf2expression, systemic antioxidant stress and therapeutic effects of hUCMSCs.

show abstract

“…SOD is critical for normal cardiac morphology and protects the heart from oxidant-induced fibrosis, apoptosis, and function loss [13]. SOD could correct the imbalance between ROSs and antioxidant scavengers and downstream effects, and it was proposed as a viable therapeutic target for DR [14]. A protective role for SOD in retinal capillary cell death was found and, ultimately, in the pathogenesis of DR [15].…”

Section: Discussionmentioning

confidence: 99%

Serum superoxide dismutase activity: a sensitive, convenient, and economical indicator associated with the prevalence of chronic type 2 diabetic complications, especially in men

Fei

Gao

et al. 2021

Free Radical Research

View full text Add to dashboard Cite

To investigate the relationship between serum superoxide dismutase (SOD) activity and the presence of chronic complications in patients with type 2 diabetes mellitus (T2DM). We conducted a retrospective cross-sectional study in patients with T2DM. They were assigned to three groups (Q1, Q2, and Q3) by SOD levels in both sexes. Clinical characteristics, cardiovascular disease, diabetic retinopathy, nephropathy, and peripheral neuropathy were compared. The relationship between the SOD and the prevalence of chronic complications was analyzed by binary logistic regression. Statistical analysis was performed in SPSS 26.0 (SPSS Inc., Chicago, IL). A total of 645 T2DM patients (401 men and 244 women) with complete data for SOD and medical records of complications were included. In men, patients in the Q1 group (lowest serum SOD activity) had the highest prevalence of diabetes with atherosclerosis (AS) (p<.001), DN (p¼.029), and DPN (p¼.001). In comparison, only DN was found to have the highest prevalence in the Q1 group in women (p¼.010). In the multivariate analysis, patients in the Q1 group had a 3.0-, 1.6-, 1.9-, and 2.4-fold risk for the prevalence of AS, DR, DN, and DPN, respectively, compared with the Q3 group. In women, a 7.0-fold risk for the prevalence of DN in the Q1 group was found compared with the Q3 group. After adjusting for the age, duration of T2DM, body mass index, pulse pressure, alanine transaminase, clearance of creatinine, triglyceride, glycosylated hemoglobin, and fasting C-peptide in the models, the differences found in both men and women persisted. SOD activity is related to cardiovascular and microvascular diseases in men and the prevalence of diabetic nephropathy in women in T2DM.

show abstract

Oxidative Stress, Diabetic Retinopathy, and Superoxide Dismutase 3

Cited by 13 publications

References 26 publications

Extracellular superoxide dismutase, a molecular transducer of health benefits of exercise

Extracellular superoxide dismutase, a molecular transducer of health benefits of exercise

TBHQ Regulates the Nrf2/HO-1 Pathway to Enhance Stem Cell Treatment of Diabetic Retinopathy

Serum superoxide dismutase activity: a sensitive, convenient, and economical indicator associated with the prevalence of chronic type 2 diabetic complications, especially in men

Contact Info

Product

Resources

About