Oxidative Stress Genes and Proteins: Fire Alarms and Fire Extinguishers

Ma, Muchou; Eaton, John W.

doi:10.1016/b978-0-08-041749-3.50007-3

Oxidative Damage &Amp; Repair 1991

DOI: 10.1016/b978-0-08-041749-3.50007-3

|View full text |Cite

Oxidative Stress Genes and Proteins: Fire Alarms and Fire Extinguishers

Muchou Ma

John W. Eaton

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

1995

2021

Publication Types

Select...

Article2

Relationship

Self Cite0

Independent2

Authors

Journals

Cited by 2 publications

(1 citation statement)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To understand this, it has to be appreciated that living organisms including humans can be thought of as resembling "slow-burning engines." 5 The oxidative processes required to burn fuel molecules are carried out in a reducing environment that acts as a "cooling system"-engines have to be cooled to prevent self-destruction.…”

mentioning

confidence: 99%

Unraveling the genetic basis of contact allergy. Will this lead to a better understanding of inter‐individual susceptibility?

Schmidt¹

2021

Contact Dermatitis

View full text Add to dashboard Cite

mentioning

confidence: 99%

Unraveling the genetic basis of contact allergy. Will this lead to a better understanding of inter‐individual susceptibility?

Schmidt¹

2021

Contact Dermatitis

View full text Add to dashboard Cite

Heme oxygenase-1 mRNA levels, metallothionein mRNA levels, lipid peroxidation and microsomal CYP1A activities in rats treated with 3,3-dichlorobenzidine and some other inducers of P450

Iba

Alam

1995

Redox Report

View full text Add to dashboard Cite

The effect of 3,3-dichlorobenzidine (DCB), a potent inducer of CYP1A, on the levels of heme oxygenase-1 mRNA and metallothionein mRNAs was examined in the kidney, liver and lung of rats administered a single ip dose (157 μmol/kg) of the compound. DCB treatment increased heme oxygenase-I mRNA abundance in the kidney significantly from barely detectable levels in untreated animals; the maximum increase in the liver and lung was 24-fold and 4-fold, respectively. Hepatic microsomal heme oxygenase activity was also induced by DCB. In contrast with DCB, 2 other P450 inducers, β-naphthoflavone (β-NF) and phenobarbital did not elevate tissue HO-1 rnRNA levels. DCB pretreatment also elevated metallothionein mRNA levels in the kidney, liver and lung, with the effect in the lung being the least pronounced. In contrast with HO-1 mRNA, metallothionein mRNA was increased by the other P450 inducers examined. In vivo lipid peroxidation and in vitro NADPH-dependent microsomal lipid peroxidation were increased in the liver of DCB-treated rats but not in those of phenobarbital- or β-naphthoflavone-treated rats. Treatment with DCB or β-NF did not alter total hepatic microsomal P450 content, as measured spectrophotometrically, but induced the activity of CYP1A2. In contrast, the activity of CYP1A1 was induced to a lesser extent by DCB than by β-NF. The data show that DCB induces HO-1 as weD as P450 1A, confirm stimulation of lipid peroxidation by the compound, and suggest oxidative stress as a mechanism of HO-1 induction by the compound.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Oxidative Stress Genes and Proteins: Fire Alarms and Fire Extinguishers

Cited by 2 publications

References 22 publications

Unraveling the genetic basis of contact allergy. Will this lead to a better understanding of inter‐individual susceptibility?

Unraveling the genetic basis of contact allergy. Will this lead to a better understanding of inter‐individual susceptibility?

Heme oxygenase-1 mRNA levels, metallothionein mRNA levels, lipid peroxidation and microsomal CYP1A activities in rats treated with 3,3-dichlorobenzidine and some other inducers of P450

Contact Info

Product

Resources

About