Oxidative Stress, Hepcidin and Nesfatin-I Status in Childhood Iron and Vitamin B12 Deficiency Anemias

Aşkar, Tünay Kontaş; Büyükleblebici, Olga; Hişmioğulları, Adnan Adil; Hünkerler, Zeynep

doi:10.17219/acem/62829

Cited by 13 publications

(4 citation statements)

References 17 publications

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“…Few studies have investigated the effect of indoor air pollution on anemia, although the investigation of chronic effects on blood health is increasing [ 1 , 32 , 33 ]. Current research is limited to assessing the relationship between fuel consumption and anemia in developing countries [ 4 , 32 ], overall outdoor air and anemia [ 8 , 11 ], and the association between anemia in children [ 34 , 35 ].…”

Section: Discussionmentioning

confidence: 99%

“…Hct refers to the percentage of the volume in contact with red blood cells (RBCs) in whole blood [ 3 ]. The WHO has defined Hb deficiency, the most representative of the BIRA, as <13 or <12 g/dL for men or women, respectively [ 4 ]. MCV is the mean Hb volume, MCH is the average Hb ratio per red blood cell, and MCHC is the Hb ratio per dl.…”

Section: Introductionmentioning

confidence: 99%

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Direct and Indirect Effects of Indoor Particulate Matter on Blood Indicators Related to Anemia

Kwag

et al. 2021

IJERPH

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Exposure to indoor particulate matter (PM) is a potential risk factor that increases systemic inflammation and affects erythropoiesis. This study investigated the association between exposure to indoor PM and blood indicators related to anemia (BIRA) in housewives. Indoor PM and blood folate status are important factors in the risk of anemia. This was a housewife cohort study; we recruited 284 housewives in Seoul and Ulsan, Republic of Korea. Indoor exposure to PM2.5 and PM10 was measured by gravimetric analysis and sensors. We investigated the BIRA, such as hemoglobin (Hb), hematocrit, mean corpuscular volume (MCV), mean corpuscular Hb (MCH), and mean corpuscular Hb concentration (MCHC). Statistical analysis was performed by multiple linear regression model and mediation analysis. The association between BIRA and PM was assessed by multiple linear regression models fitted by mediation analyses. The increase in the level of indoor PM2.5 was associated with a decrease in MCV (Beta coefficient (B): −0.069, Standard error (SE): 0.022) and MCH (B: −0.019, SE: 0.009) in gravimetric measurements. The increase in the level of indoor PM2.5 was associated with a decrease in Hb (B: −0.024, SE: 0.011), hematocrit (B: −0.059, SE: 0.033), and MCV (B: −0.081, SE: 0.037) and MCH (B: −0.037, SE: 0.012) in sensor measurements (PM2.5-Lag10). Further, we identified a serum folate-mediated PM effect. The indoor PM exposure was significantly associated with decreased Hb, MCV, and MCH in housewives. Taken together, our data show that exposure to indoor PM is a risk factor for anemia in housewives. Blood folate concentration can be a mediating factor in the effect of indoor PM on BIRA. Therefore, folate intake should be recommended to prevent anemia in housewives. Moreover, indoor PM exposure should be managed.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Direct and Indirect Effects of Indoor Particulate Matter on Blood Indicators Related to Anemia

Kwag

et al. 2021

IJERPH

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“…This response is consistent with the prior demonstration of an association between (1) cell oxidant generation and cytokine production/release and (2) iron availability. Comparable to a decreased availability of metal following particle exposure, iron deficiency in cells, animal models, and humans can be associated with an augmented generation of oxidants. − In the same way, different cell types demonstrate a capacity to release of pro-inflammatory cytokines dependent on concentrations of iron. ,− AMs show the same relationship between levels of levels of cytokine release associated with elevated metal availability following exposures to iron-coated quartz, deferoxamine, endotoxin, and microbials. − …”

Section: Discussionmentioning

confidence: 99%

Quartz Disrupts Iron Homeostasis in Alveolar Macrophages To Impact a Pro-Inflammatory Effect

Ghio

Soukup

Stonehuerner

et al. 2019

Chem. Res. Toxicol.

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The biological response of bronchial epithelial cells to particles is associated with a sequestration of cell metal by the particle surface and a subsequent disruption in host iron homeostasis. The macrophage is the cell type resident in the respiratory tract that is most likely to make initial contact with inhaled particles. We tested the postulates that (1) silica, a prototypical particle, disrupts iron homeostasis in alveolar macrophages (AMs); and (2) the altered iron homeostasis results in both an oxidative stress and pro-inflammatory effects. Human AMs (1.0 × 10 6 /mL) demonstrated an increased import of iron following particle exposure with nonheme iron concentrations of 0.57 ± 0.03, 1.72 ± 0.09, 0.88 ± 0.09, and 3.21 ± 0.11 ppm in cells exposed for 4 h to media, 500 μM ferric ammonium citrate (FAC), 100 μg/mL silica, and both silica and FAC, respectively. Intracellular ferritin concentrations and iron release were similarly increased after AM exposure to FAC and silica. Silica increased oxidant generation by AMs measured using both dichlorofluorescein diacetate fluorescence and reduction of nitroblue tetrazolium salt. Concentrations of interleukin (IL)-1β, IL-6, IL-8, and tumor necrosis factor-α in macrophage supernatant increased following 100 μg/mL silica exposure for 24 h. Treatment of AMs with 500 μM FAC decreased both oxidant generation and cytokine release associated with silica exposure, supporting a dependence of these effects on sequestration of cell metal by the particle surface. We conclude that (1) silica exposure disrupts iron homeostasis resulting in increased import, accumulation, and release of the metal; and (2) the altered iron homeostasis following silica exposure impacts oxidant generation and pro-inflammatory effects.

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“…During anemia, hepcidin creates an important link between the body’s defense, inflammation, and iron metabolism. A previous study has shown that during infection and inflammation, hepcidin synthesis is considerablely increased owing to stimulation by IL-6 5…”

Section: Introductionmentioning

confidence: 99%

Changes in pro-inflammatory cytokines and antimicrobial proteins in elderly women with iron deficiency anemia

Aşkar

DEVEBOYNU

Er³

et al. 2019

Pak J Med Sci

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Objective: Iron Deficiency Anemia (IDA) is common nutritional deficiency particularly in women and also common during the older age. Aging increases plasma levels of inflammatory mediators such as pro-inflammatory cytokines and acute phase proteins. However, there is little information about changes in antimicrobial proteins in elderly women with IDA. In this study, we aimed to determine the changes in pro-inflammatory cytokines and newly discovered antimicrobial proteins like hepcidin, chemerin and defensin in elderly women with IDA. Methods: Blood samples taken from healthy 20 women (55±7 years old) and 20 women with iron deficiency anemia (58±6) were used as material of the study that came to the Cankiri State Hospital in 2016 and 2017 years. Results: In the study, plasma C-Reactive Protein (CRP) (P <0.01), tumour necrosis factor-α (TNF-α) (P <0.05) and interleukin-6 (IL-6) levels (P <0.05) were significantly increased in group with IDA when compared with healthy group. Also plasma hepcidin (P <0.001), chemerin (P <0.05) and defensin levels (P <0.05) were determined significantly higher than the healthy group. Conclusion: We found that inflammatory changes occur in elderly women with IDA. Besides pro-inflammatory cytokine levels (CRP, IL-6, TNF-α), antimicrobial protein levels (hepcidin, chemerin, defensin) were found higher in elderly women with IDA because of inflammatory changes. How to cite this:Askar S, Deveboynu SN, Hilal ER, Askar TK, Adnan Adil Hismiogullari5. Changes in pro-inflammatory cytokines and antimicrobial proteins in elderly women with iron deficiency anemia. Pak J Med Sci. 2019;35(2):---------. doi: https://doi.org/10.12669/pjms.35.2.520 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Oxidative Stress, Hepcidin and Nesfatin-I Status in Childhood Iron and Vitamin B12 Deficiency Anemias

Abstract: Background. Anemia is a disease that is long and often repetitive and can result in a great burden to the national economy. The most frequent nutritional deficiency anemias in children are related with iron and vitamin B12 deficiencies.

Cited by 13 publications

References 17 publications

Direct and Indirect Effects of Indoor Particulate Matter on Blood Indicators Related to Anemia

Direct and Indirect Effects of Indoor Particulate Matter on Blood Indicators Related to Anemia

Quartz Disrupts Iron Homeostasis in Alveolar Macrophages To Impact a Pro-Inflammatory Effect

Changes in pro-inflammatory cytokines and antimicrobial proteins in elderly women with iron deficiency anemia

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