Oxidative stress impairs endothelial nitric oxide levels in Behçets’ disease

Onur, Ece; Kabaroğlu, Ceyda; İnanır, Işıl; Var, Ahmet; Güvenç, Yeşim; Günay, Özlem; Gündüz, Kamer

doi:10.3109/15569527.2011.554480

Cited by 28 publications

(20 citation statements)

References 20 publications

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“…In vitro studies have revealed that the major cause related with the etiopathogenesis in patients with BD is induction of endothelial cells by oxidative stress. 9,10 Endocan is a dermatan sulphate proteoglycan molecule. It is an endothelial marker expressed by endothelial cells.…”

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confidence: 99%

Endocan Measurement for Active Behçet Disease

et al. 2017

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Objectives: This study aims to investigate the relationships between serum endocan, vascular endothelial growth factor (VEGF), and tumor necrosis factor-alpha (TNF-α) levels in active Behçet disease. Patients and methods: Forty patients with active Behçet disease (24 males, 16 females; mean age 37.6±8.7 years; range 20 to 50 years) and 40 healthy controls (22 males, 18 females; mean age 38.8±7.9 years; range 21 to 52 years) were included in this study. Both patient and control groups underwent a complete systemic and ophthalmic examination by the same specialist. Endocan, VEGF, and TNF-α levels were measured with an enzyme-linked immunosorbent assay kit in all subjects. Results: Serum endocan levels were 775.2±479.3 ng/mL and 275.8±145.8 ng/mL in the patient and control groups, respectively. VEGF levels were 1768.2±900.5 pg/mL and 980.2±135.3 pg/mL in the patient and control groups, respectively. TNF-α levels were 22.4±74.3 pg/mL-1 and 11.4±16.9 pg/mL-1 in the patient and control groups, respectively. There was a statistically significant difference between groups in terms of serum endocan, VEGF, and TNF-α levels. There was a significant positive correlation between serum endocan and VEGF levels in the patient group (r=0.630; p<0.001). Also, there was a significant positive correlation between serum endocan and TNF-α levels in the patient group (r=0.713; p<0.001). Conclusion: Serum endocan level may be a new marker in evaluation of both the prognosis and activity of Behçet disease.

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confidence: 99%

Endocan Measurement for Active Behçet Disease

et al. 2017

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“…Decreased activity of NO (also known as endothelium-derived relaxing factor) leads to vasoconstriction, monocyte adhesion, and platelet aggregation, which may lead to vascular dysfunction, separately or in combination, seen in BD [18]. Along with increased serum ADMA levels, lower NO levels have been reported to be a significant contributor to ED observed in BD [19][20][21]. Both the inhibition of NO synthase by ADMA and oxidant/ antioxidant imbalance may contribute to decreased bioavailability of NO in BD.…”

Section: Discussionmentioning

confidence: 92%

Novel markers of endothelial dysfunction and inflammation in Behçet’s disease patients with ocular involvement: epicardial fat thickness, carotid intima media thickness, serum ADMA level, and neutrophil-to-lymphocyte ratio

et al. 2015

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The etiology of Behçet's disease (BD) has not been fully elucidated. However, immunological and environmental factors, endothelial dysfunction (ED), and genetic susceptibility have been proposed to play a role. In this study, we aimed to evaluate epicardial fat thickness (EFT) together with serum asymmetric dimethylarginine (ADMA), carotid intima media thickness (CIMT), and neutrophil-to-lymphocyte ratio (NLR) in BD patients with ocular involvement. Thirty-six ocular BD patients (17 active and 19 inactive ocular involvement), and 35 age and sex-matched healthy controls were enrolled to this cross-sectional study. All patients underwent examinations with transthoracic echocardiography and carotid Doppler ultrasound. Serum ADMA levels, CIMT, EFT, and NLR were compared between groups, and their association with disease activity was evaluated. Behçet's disease patients had higher WBC counts, neutrophil counts, NLR, CIMT, EFT values, and serum ADMA levels than do healthy controls. The other biochemical, hematological, and echocardiographic parameters were comparable between the two groups. Behçet's disease duration was positively correlated with EFT and CIMT. Multivariate logistic regression analysis revealed that increased serum ADMA concentration and CIMT are independently associated with BD. Neutrophil counts, NLR, and serum ADMA level were higher, and lymphocyte count was lower in patients with active ocular BD compared to those of inactive ocular BD group. Carotid intima media thickness, serum ADMA level, EFT, and NLR were increased in ocular BD patients compared to healthy subjects. In addition, both serum ADMA level and NLR were associated with disease activity of ocular involvement. Increase in disease duration was associated with increase in CIMT and EFT which suggests that anatomical changes occur in time during the disease course. Increased CIMT, serum ADMA level, EFT, and NLR may provide new clues about the role of ED and inflammation in the etiopathogenesis of BD.

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“…Endogenous NO, produced by endothelial cells, is known for its multiple effects, such as vasodilative, antiplatelet and antiproliferative ones [67]. NO levels are reported to be low in BD patients compared to the healthy population, especially in patients with active BD.…”

Section: The Central Role Of Blood Vessel Endothelium In Vasculitis-amentioning

confidence: 99%

Thrombosis in vasculitic disorders−clinical manifestations, pathogenesis and management

Katz¹,

Brenner

Horowitz

2015

Thrombosis Research

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Oxidative stress impairs endothelial nitric oxide levels in Behçets’ disease

Abstract: Decreased NO levels mediated by increased oxidative stress significantly contribute to endothelial dysfunction observed in BD.

Cited by 28 publications

References 20 publications

Endocan Measurement for Active Behçet Disease

Endocan Measurement for Active Behçet Disease

Novel markers of endothelial dysfunction and inflammation in Behçet’s disease patients with ocular involvement: epicardial fat thickness, carotid intima media thickness, serum ADMA level, and neutrophil-to-lymphocyte ratio

Thrombosis in vasculitic disorders−clinical manifestations, pathogenesis and management

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