Oxidative stress in acute ischemic stroke

Özkul, Ayça; Akyol, Ali; Yenisey, Çiğdem; Arpaci, Esra; Kıylıoğlu, Nefati; Tataroglu, Cengiz

doi:10.1016/j.jocn.2006.11.008

Cited by 134 publications

(89 citation statements)

References 37 publications

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“…As a result, permeability of the blood-brain barrier increases and life-threatening cerebral edema develops (22,23). In many studies, it has been shown that I/R in the brain is related to lipid peroxidation that causes oxidative destruction of the cell membrane and provides autocatalytic mechanisms (24,25). GSH is an intracellular tripeptide composed of glutamic acid, cysteine, and glycine.…”

Section: Discussionmentioning

confidence: 99%

Does Glp-2 have a protective effect on cerebral ischemia/reperfusion model?

Topaloğlu¹,

Memi²,

Kaner³

et al. 2015

Turk J Med Sci

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Background/aim: To investigate the neuroprotective effects of glucagon-like peptide 2 (Glp-2), which increases cerebral blood flow, on the hippocampal complex after cerebral ischemia/reperfusion (I/R) injury in rats.Materials and methods: Animals were randomized into 4 groups: sham, I/R + 0.9% NaCl, I/R + pre-Glp-2, and I/R + post-Glp-2. Cerebral ischemia was performed via the occlusion of the bilateral internal carotid artery for 40 min and continued with a reperfusion process. At the end of 6 h of reperfusion, animals were decapitated in all groups and brain tissues were removed. Malondialdehyde (MDA) and natural intracellular antioxidant glutathione (GSH) levels and myeloperoxidase (MPO) activities were measured in the left hippocampal tissue. The right hippocampal tissues of all group members were taken for histopathologic study.Results: MDA levels and MPO activities increased from Group I to Group II and decreased from Group II to Groups III and IV. On the other hand, GSH levels were not significantly different among the groups. The number of apoptotic hippocampal tissue cells increased from Group I to Group II and decreased from Group II to Groups III and IV. Conclusion:Our preliminary study revealed that Glp-2 treatment may decrease oxidative damage from I/R in cerebral tissue.

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Section: Discussionmentioning

confidence: 99%

Does Glp-2 have a protective effect on cerebral ischemia/reperfusion model?

Topaloğlu¹,

Memi²,

Kaner³

et al. 2015

Turk J Med Sci

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“…In another study, plasma concentrations of α-and β-carotene were lower in patients with acute ischemic stroke than healthy controls, and were negatively associated with high sensitivity C-reactive protein level and the National Institute of Health Stroke Scale (NIHSS) score after adjustment for age and sex [18]. Similarly, in a study of 70 patients with acute ischemic stroke and 70 controls with similar risk factors, serum levels of NO, malondialdehyde, and glutathione were significantly elevated in stroke patients, and the levels of NO and malondialdehyde correlated with the Canadian Neurological Scale score [19]. Taffi et al [20] investigated changes in NO and OS status in 47 acute stroke patients and age-and sex-matched healthy subjects.…”

Section: Ischemic Strokementioning

confidence: 91%

Antioxidant Strategies in Neurocritical Care

Hanafy

Selim

2012

Neurotherapeutics

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An increase in oxidative stress and overproduction of oxidizing reactive species plays an important role in the pathophysiology of several conditions encountered in the neurocritical care setting including: ischemic and hemorrhagic strokes, traumatic brain injury, acute respiratory distress syndrome, sepsis, and organ failure. The presence of oxidative stress in these conditions is supported by a large body of preclinical and clinical studies, and provides a rationale to support a potential therapeutic role for antioxidants. The purpose of this article is to briefly review the basic mechanisms and molecular biology of oxidative stress, summarize its role in critically ill neurological patients, and review available data regarding the potential role of antioxidant strategies in neurocritical care and future directions.

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“…Higher circulating levels of MDA in patients with ischemic stoke than in controls have been found [68][69][70][71][72][73][74][75][76][77][78][79][80] ; and also there has been found an association between circulating levels of MDA and neurological functional outcome in ischemic stroke patients [81][82][83] .…”

Section: Malondialdehydementioning

confidence: 99%

“…Oxidative stress leads to the peroxidation of membrane lipids, and this process generates several end products, such as malondialdehyde (MDA). MDA is a low molecular weight aldehyde and appears due to the attacks from free radical to phospholipids of cellular membrane; and the determination of MDA levels has been used as an effective biomarker of lipid oxidation [66,67] .Higher circulating levels of MDA in patients with ischemic stoke than in controls have been found [68][69][70][71][72][73][74][75][76][77][78][79][80] ; and also there has been found an association between circulating levels of MDA and neurological functional outcome in ischemic stroke patients [81][82][83] .In a study by our team were found higher serum MDA levels (p < 0.001) in patients with MMCAI than in healthy subjects [84] . In addition, we found for the first time, higher serum levels of MDA in non-surviving than in surviving patients, and that there is an association between serum MDA levels and 30-day mortality.…”

mentioning

confidence: 99%

New prognostic biomarkers in patients with ischemic stroke

Lorente

2016

Mol Med Chem

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Ischemic stroke leads to disability and mortality and involved great consumption of resources. This review focuses on new prognostic biomarkers of mortality in patients with ischemic stroke in relation to the inflammation, coagulation, and oxidation. Blood concentration of tissue inhibitor of matrix metalloproteinases (TIMP)-1, soluble CD154 (sCD154), and malondialdehyde (MDA) in ischemic stroke patients have been recently found to be associated with mortality. Matrix metalloproteinases (MMPs) are zinc-containing endoproteinases involved in neuroinflammation during cerebral ischemia and TIMP-1 is the inhibitor of some of them. sCD154 is a member of the tumor necrosis factor (TNF) family that is released into circulation from different cells and when binding to their cell surface receptor showed proinflamatory and procoagulant properties. MDA is a low molecular weight aldehyde and appears due to the attacks from free radical to phospholipids of cellular membrane. The determination of circulating levels of those biomarkers could help in the prognostic classification of the patients. In addition, the modulation of those pathways could open new research lines for the treatment of ischemic stroke patients.Keywords: Ischemic stroke; biomarkers; TIMP-1; sCD154; malondialdehyde To cite this article: Leonardo Lorente. New prognostic biomarkers in patients with ischemic stroke. Mol Med Chem 2015; 1: e972. doi: 10.14800/mmc.972. IntroductionIschemic stroke leads to disability and mortality and involved great consumption of resources [1] . This review focuses on new prognostic biomarkers of mortality in patients with ischemic stroke in relation to the inflammation, coagulation, and oxidation. Tissue inhibitor of matrix metalloproteinases-1Matrix metalloproteinases (MMPs) are zinc-containing endoproteinases, which could be classified according to the substrate specificity in gelatinases (MMP-2 and MMP-9), collagenases (MMP-1, MMP-8 and MMP-13), stromelysins (MMP-3, MMP-10, MMP-11), matrilysins (MMP-7), elastases (MMP-12) and membrane-type (MMP-14, MMP-15, MMP-16 and MMP-17). MMPs are involved in the processes of degradation and remodelling of the extracellular matrix (ECM). MMP activity is regulated by tissue inhibitor of matrix metalloproteinases (TIMPs). MMPs are involved in physiological functions such as morphogenesis, tissue remodelling, menstrual cycle, and angiogenesis; and also in different diseases as tumour, arthritis, sepsis, and atherosclerosis [2] .Cerebral ischemia activate an inflammatory response and are released different cytotoxic agents, such as MMPs, which could favorate disruption of the blood-brain barrier (BBB) and cell damage [3] .There have been found higher circulating MMP-9 levels in ischemic stroke patients than in controls [4][5][6][7][8] , and also in patients with ischemic stroke and worse functional outcome compared with patients with better outcome [4][5][6][7][8][9][10][11][12] . Also, higher circulating levels of MMP-10 in ischemic stroke patients than in controls there have been f...

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Oxidative stress in acute ischemic stroke

Cited by 134 publications

References 37 publications

Does Glp-2 have a protective effect on cerebral ischemia/reperfusion model?

Does Glp-2 have a protective effect on cerebral ischemia/reperfusion model?

Antioxidant Strategies in Neurocritical Care

New prognostic biomarkers in patients with ischemic stroke

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