Oxidative stress in blood leukocytes, pro/antioxidanт status and fatty acids composition of pancreas lipids at experimental acute pancreatitis in rats

Pryvrotska, I. B.; Kuchmerovska, Т. М.

doi:10.15407/ubj85.05.124

Cited by 2 publications

(1 citation statement)

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“…In this study, total antioxidant status, catalase, and superoxide dismutase, as well as total glutathione, were decreased compared with the control untreated group. This is consistent with existing research, where it was shown that the antioxidant status decreases and is postulated to be associated with pancreatic beta cell death [24] or with pancreatic fibrosis [25]. We also observed an increase in levels of oxidative stress only with KIO3.…”

Section: Discussionsupporting

confidence: 93%

Excess Iodine Consumption Induces Oxidative Stress and Pancreatic Damage Independently of Chemical Form in Male Wistar Rats: Participation of PPAR-γ and C/EBP-β

Arbez-Evangelista,

Arroyo-Xochihua,

Ortega-Ibarra

et al. 2024

Biology

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Background: Human beings consume different chemical forms of iodine in their diet. These are transported by different mechanisms in the cell. The forms of iodine can be part of thyroid hormones, bind to lipids, be an antioxidant, or be an oxidant, depending on their chemical form. The excessive consumption of iodine has been associated with pancreatic damage and diabetes mellitus type 2, but the association between disease and the chemical form consumed in the diet is unknown. This research analyzes the effect of excessive iodine consumption as Lugol (molecular iodine/potassium iodide solution) and iodate on parameters of pancreatic function, thyroid and lipid profiles, antioxidant and oxidant status, the expression of IR/Akt/P-Akt/GLUT4, and transcription factors PPAR-γ and CEBP-β. Methods: Three groups of Wistar rats were treated with 300 μg/L of iodine in drinking water: (1) control, (2) KIO3, and (3) Lugol. Results: Lugol and KIO3 consumption increased total iodine levels. Only KIO3 increased TSH levels. Both induced high serum glucose levels and increased oxidative stress and pancreatic alpha-amylase activity. Insulin levels and antioxidant status decreased significantly. PPAR-γ and C/EBP-β mRNA expression increased. Conclusion: The pancreatic damage, hypertriglyceridemia, and oxidative stress were independent of the chemical form of iodine consumed. These effects depended on PPAR-γ, C/EBP-β, GLUT-4, and IR.

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Section: Discussionsupporting

confidence: 93%