Oxidative Stress in Cardiovascular Disease and Comorbidities

Zalba, Guillermo; Moreno, María U.

doi:10.3390/antiox11081519

Cited by 5 publications

(3 citation statements)

References 10 publications

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“…In addition, the current study did not show comorbidities. The literature has emphasized that the imbalance between ROS production and antioxidant agents has been strongly correlated with the development of different cardiovascular pathologies (Zalba & Moreno, 2022 ).…”

Section: Discussionmentioning

confidence: 99%

High‐fat, high‐sucrose, and combined high‐fat/high‐sucrose diets effects in oxidative stress and inflammation in male rats under presence or absence of obesity

Kobi

Matias

Gasparini

et al. 2023

Physiological Reports

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Section: Discussionmentioning

confidence: 99%

High‐fat, high‐sucrose, and combined high‐fat/high‐sucrose diets effects in oxidative stress and inflammation in male rats under presence or absence of obesity

Kobi

Matias

Gasparini

et al. 2023

Physiological Reports

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“…Nevertheless, when ROS production exceeds the antioxidant capacities, so-called oxidative stress occurs, and chronic, accumulated oxidative stress can lead to a wide variety of diseases such as cancer [ 25 ], neurodegenerative disease [ 26 ], respiratory disease [ 27 ], and kidney disease [ 28 ]. Furthermore, particularly important for this review, oxidative stress has been associated with a range of CVDs, such as atherosclerosis, ischemic heart disease, hypertension, cardiomyopathy, cardiac hypertrophy, and congestive heart failure [ 29 , 30 , 31 ]. In addition, their contribution to the development of vascular disease has also been well-reported, and the following reviews will provide good information on the subject [ 32 , 33 , 34 ].…”

Section: Ros At Glancementioning

confidence: 99%

Cardiovascular Disease and miRNAs: Possible Oxidative Stress-Regulating Roles of miRNAs

Lee

2024

Antioxidants

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MicroRNAs (miRNAs) have been highlighted as key players in numerous diseases, and accumulating evidence indicates that pathological expressions of miRNAs contribute to both the development and progression of cardiovascular diseases (CVD), as well. Another important factor affecting the development and progression of CVD is reactive oxygen species (ROS), as well as the oxidative stress they may impose on the cells. Considering miRNAs are involved in virtually every biological process, it is not unreasonable to assume that miRNAs also play critical roles in the regulation of oxidative stress. This narrative review aims to provide mechanistic insights on possible oxidative stress-regulating roles of miRNAs in cardiovascular diseases based on differentially expressed miRNAs reported in various cardiovascular diseases and their empirically validated targets that have been implicated in the regulation of oxidative stress.

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“…The antihypertensive effects of plants are attributed to their diuretic, vasodilator and antioxidant properties because oxidative stress is considered a risk factor in hypertension and cardiovascular diseases [7]. Reactive oxygen species (ROS) produced in all vascular cells including endothelial, smooth muscle cells play an important role in the pathophysiology of hypertension by causing vascular damage and reducing the production of nitric oxide (NO) [8].…”

Section: Introductionmentioning

confidence: 99%

Antihypertensive activity of Lugwigia octovalvis (Jacq.) P. H. Raven (Onagraceae) hydro alcoholic extract on rat

RATOVONARINDRA¹,

RAKOTOARISON²,

Rasolohery³

et al. 2023

World J. Bio. Pharm. Health Sci.

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Our objective was to study the activity of Ludwigia octovalvis hydro alcoholic extract in rats made experimentally hypertensive by a hypersodic diet. After 21 days of this diet, the systolic and diastolic blood pressure of these animals increases to 200.1 ± 1.5 / 155.6 ± 1.5 mm Hg, respectively. Administered orally, the extract reduces this high blood pressure. The control group blood pressure returned to its normal value (113.2 ± 1.2/76.3 ± 1) mm Hg after 24 days, versus 9th, 15th and 19th days for animals treated with the extract at doses of 400, 200 and 100 mg / kg (P <0.05). It does not have any diuretic activity but relaxes the isolated aorta contracted with norepinephrine 10-4 M with an EC50 equal to 1.18 ± 0.02 mg/ml. These results indicate that Ludwigia octovalvis extract has an antihypertensive activity by its vasodilator property. The polyphenols, triterpenoids and flavonoids in the extract may be responsible for its hypotensive activity.

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Oxidative Stress in Cardiovascular Disease and Comorbidities

Abstract: Reactive oxygen species (ROS), both as second messengers and as contributors to oxidative stress, play a major, complex role in the initiation, development and outcomes of cardiovascular diseases [...]

Cited by 5 publications

References 10 publications

High‐fat, high‐sucrose, and combined high‐fat/high‐sucrose diets effects in oxidative stress and inflammation in male rats under presence or absence of obesity

High‐fat, high‐sucrose, and combined high‐fat/high‐sucrose diets effects in oxidative stress and inflammation in male rats under presence or absence of obesity

Cardiovascular Disease and miRNAs: Possible Oxidative Stress-Regulating Roles of miRNAs

Antihypertensive activity of Lugwigia octovalvis (Jacq.) P. H. Raven (Onagraceae) hydro alcoholic extract on rat

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