Oxidative stress in cervical cancer and its response to chemoradiation

Shah, Saiqa R.; Kalal, Bhuvanesh Sukhlal

doi:10.4274/tjod.galenos.2019.19577

Cited by 12 publications

(5 citation statements)

References 30 publications

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“…Our results are consistent with the results of other investigations. In another report, the TAC levels in cervical cancer patients and controls were 1320 ± 0.029 SD lmol Trilox equivalent/L and 1620 ± 0.042 SD lmol Trilox equivalent/L, respectively [33]. Subramanyam reported TAC levels in cervical cancer patients and controls as 1000.2 ± 2.44 SD lmol Trilox equivalent/L and 3100 ± 1.24 SD lmol Trilox equivalent/L, respectively, which is similar to our findings [34].…”

Section: Discussionmentioning

confidence: 85%

Total Antioxidant Capacity and Lipid Peroxidation Status in Cervical Cancer Patients Compared with Women Without Cervical Cancer in Bangladesh

Nigar

Goodman

Pervin

2021

Indian J Gynecol Oncolog

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Purpose Over the past several decades, research has suggested reactive oxygen species act as cofactors for cervical cancer development. The aim of this study is to evaluate the antioxidant and lipid peroxidation status in cervical cancer patients in Bangladesh. Methods From December 2017 to 2018, a cross-sectional observational study was conducted on 50 cervical cancer patients and 50 controls. Plasma levels of lipid peroxidation and total antioxidant capacity were measured. The Student’s t test was used for statistical analysis. P values less than 0.05 were taken as a level of significance. Results There was a significant reduction in total antioxidant levels in patients with cervical cancer, 972.77 ± 244.22 SD µmol equivalent to ascorbic acid/L, compared to normal controls, 1720.13 ± 150.81 SD µmol equivalent to ascorbic acid/L (P < 0.001). Levels of lipid peroxidation were found to be significantly higher in cervical cancer, 7.49 ± 2.13 SD µmol/L, than in women without cervical cancer, 3.28 ± 0.58 SD µmol/L (P < 0.001). The cervical cancer patients had significantly higher levels of oxidative stress index (0.83 ± 0.31) in comparison to controls (0.19 ± 0.04) (P < 0.001). Conclusion There was an increased oxidative stress index due to imbalance between lipid peroxidation generation and total antioxidant capacity in cervical cancer patients. Further studies are needed to explore the role of oxidative stress as a cofactor for cervical carcinogenesis.

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Section: Discussionmentioning

confidence: 85%

Total Antioxidant Capacity and Lipid Peroxidation Status in Cervical Cancer Patients Compared with Women Without Cervical Cancer in Bangladesh

Nigar

Goodman

Pervin

2021

Indian J Gynecol Oncolog

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“…HT pathophysiology in diabetics involves complex interactions with many environmental factors and between the nervous, cardiovascular and renin-angiotensin systems (5). It also includes physiological changes such as increased levels of blood sugar levels and abnormal levels of lipids, increased oxidative stress, chronic inflammation, hypoxia and ischemia (6,7).…”

Section: Introductionmentioning

confidence: 99%

Serum Ischemia-Modified Albumin, Fibrinogen, High Sensitivity C- Reactive Proteins in Type-2 Diabetes Mellitus without Hypertension and Diabetes Mellitus with Hypertension: A Case-Control Study

et al. 2020

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Background:The objective of this study was to determine the levels of serum ischemia-modified albumin (IMA), fibrinogen (FIB) and high sensitivity C-reactive protein (hs-CRP) in type 2 diabetes mellitus (T2DM) patients with hypertension (HT) (DMT2HTN) and without HT (DMT2). Also, their association with certain biochemical and physical factors were studied to identify possible risk factors that lead to cardiovascular complications. Methods: Fasting blood samples were collected from 35 DMT2 or DMT2HTN patients each to analyze differences in serum and plasma levels of IMA, hs-CRP, FIB, total cholesterol (TC), high and low density lipoproteins (HDL and LDL), triglyceride (TG), hemoglobin A1c (HbA1C), glycated hemoglobin and creatinine. Results: In DMT2 and DMT2HTN patients, IMA, hs-CRP, FIB, TC, TG, HDL, LDL, glycated hemoglobin and creatinine levels, including body mass index (BMI) and waist-to-hip ratio (WHR), were significantly higher relative to healthy controls. In addition, the levels of IMA, hs-CRP and FIB levels showed a strong link to BMI, WHR, TC, TG, LDL and glycated hemoglobin. Lastly, both DMT2 and DMT2HTN patients demonstrated a significant reduction in HDL. Conclusions: DMT2 and DMT2HTN patients have a greater risk of developing cardiovascular related complications. This study suggests that quantifying hs-CRP, IMA and FIB levels can help diagnose the risk of developing complications during the early stages of metabolic and cardiovascular disease. Overall, the specific risk factors may be used for early identification of cardiovascular complications to decrease mortality and morbidity in T2DM patients.

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“…CC patients had the highest Cu concentrations [178], and this increase was positively correlated with the stages of the disease, while Cu decreased after different treatments (surgery, chemotherapy, radiotherapy, or a combination of both) [179]. This result differs from a study where the authors observed that increased serum Cu levels were not modified after chemoradiotherapy in patients with CC [180]. In summary, Cu is indicated as a possible risk factor associated with CC that could be useful to monitor this type of cancer and potentially to control the progress of the disease [177][178][179].…”

Section: Uterine Diseases 221 Uterine Cervix Cancermentioning

confidence: 61%

Copper in Gynecological Diseases

Conforti,

Delsouc,

Zorychta

et al. 2023

IJMS

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Copper (Cu) is an essential micronutrient for the correct development of eukaryotic organisms. This metal plays a key role in many cellular and physiological activities, including enzymatic activity, oxygen transport, and cell signaling. Although the redox activity of Cu is crucial for enzymatic reactions, this property also makes it potentially toxic when found at high levels. Due to this dual action of Cu, highly regulated mechanisms are necessary to prevent both the deficiency and the accumulation of this metal since its dyshomeostasis may favor the development of multiple diseases, such as Menkes’ and Wilson’s diseases, neurodegenerative diseases, diabetes mellitus, and cancer. As the relationship between Cu and cancer has been the most studied, we analyze how this metal can affect three fundamental processes for tumor progression: cell proliferation, angiogenesis, and metastasis. Gynecological diseases are characterized by high prevalence, morbidity, and mortality, depending on the case, and mainly include benign and malignant tumors. The cellular processes that promote their progression are affected by Cu, and the mechanisms that occur may be similar. We analyze the crosstalk between Cu deregulation and gynecological diseases, focusing on therapeutic strategies derived from this metal.

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Oxidative stress in cervical cancer and its response to chemoradiation

Cited by 12 publications

References 30 publications

Total Antioxidant Capacity and Lipid Peroxidation Status in Cervical Cancer Patients Compared with Women Without Cervical Cancer in Bangladesh

Total Antioxidant Capacity and Lipid Peroxidation Status in Cervical Cancer Patients Compared with Women Without Cervical Cancer in Bangladesh

Serum Ischemia-Modified Albumin, Fibrinogen, High Sensitivity C- Reactive Proteins in Type-2 Diabetes Mellitus without Hypertension and Diabetes Mellitus with Hypertension: A Case-Control Study

Copper in Gynecological Diseases

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