Oxidative Stress in Chronic Liver Disease and Portal Hypertension: Potential of DHA as Nutraceutical

Boyer‐Díaz, Zoe; Morata, Paloma; Aristu-Zabalza, Peio; Gibert‐Ramos, Albert; Bosch, Jaime; Gracia‐Sancho, Jordi

doi:10.3390/nu12092627

Cited by 19 publications

(14 citation statements)

References 87 publications

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“…Moreover, in return, the accelerated generation of ROS worsened the oxidative degree to the body. Similar trends of the elevated ROS levels, along with the lipid oxidation, were demonstrated not only in the organs of NAFLD/NASH [46,47], but also of other metabolic syndromes, such as diabetes mellitus [16,48], hypertension [49,50], CKD [51,52], and atherosclerosis [53]. Furthermore, the deficiency of the physiological lipids, particularly PUFA, ethanolamine phospholipids, and CL, leads to biomembrane dysfunction-related disturbances, especially mitochondrial dysfunction, which could oppositely cause free radical production and lipid peroxidation [29,54].…”

Section: Accumulation Of Oxidized Lipid Species In Liver and Kidney Of Nash Model Micesupporting

confidence: 62%

“…In contrast, there was no such difference for the kidney (Normal, 1462.5 nmol/g; NASH, 1382.2 nmol/g). Taking consideration of the molecular composition, as Figure 2C shows, the total TG accumulation in the NASH liver was predominantly due to the accretion of the more saturated species, especially those with shorter carbon chain length (i.e., [44][45][46][47][48][49][50][51][52][53][54] and fewer double bonds (i.e., 0-4). Even for the longer chain (e.g., C60) TG species, the changing trends depended on double bonds: those with fewer double bonds increased, and those with more double bonds decreased.…”

Section: Tg Accumulation In Nash Liver and Profile Alteration In Nash Kidneymentioning

confidence: 99%

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Oxidative Stress Linked Organ Lipid Hydroperoxidation and Dysregulation in Mouse Model of Nonalcoholic Steatohepatitis: Revealed by Lipidomic Profiling of Liver and Kidney

Chen

Fuda

et al. 2021

Antioxidants

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Nonalcoholic steatohepatitis (NASH) is a prevalent disease related to lipid metabolism disorder and oxidative stress. Lipid hydroperoxidation is known to be a critical driving force of various disorders and diseases. However, the combination of both intact and hydroperoxidized lipids in NASH has not yet been studied. In this work, the liver and kidney samples from NASH-model mice were comprehensively investigated by using the LC/MS-based lipidomic analysis. As a result, triglycerides showed the amount accumulation and the profile alteration for the intact lipids in the NASH group, while phosphatidylethanolamines, lysophosphatidylethanolamines, plasmalogens, and cardiolipins largely depleted, suggesting biomembrane damage and mitochondria dysfunction. Notably, the lipid hydroperoxide species of triglyceride and phosphatidylcholine exhibited a significant elevation in both the liver and the kidney of the NASH group and showed considerable diagnostic ability. Furthermore, the relationship was revealed between the lipid metabolism disturbance and the lipid hydroperoxide accumulation, which played a key role in the vicious circle of NASH. The present study suggested that the omics approach to the lipid hydroperoxide profile might be the potential diagnostic marker of NASH and other oxidative stress-related diseases, as well as the evaluative treatment index of antioxidants.

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Section: Accumulation Of Oxidized Lipid Species In Liver and Kidney Of Nash Model Micesupporting

confidence: 62%

Section: Tg Accumulation In Nash Liver and Profile Alteration In Nash Kidneymentioning

confidence: 99%

Oxidative Stress Linked Organ Lipid Hydroperoxidation and Dysregulation in Mouse Model of Nonalcoholic Steatohepatitis: Revealed by Lipidomic Profiling of Liver and Kidney

Chen

Fuda

et al. 2021

Antioxidants

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“…A large number of studies have shown that the degree of portal hypertension is an important prognostic factor for liver dysfunction. , Additionally, necrotizing inflammation of the liver can promote the increase of hepatic vascular tension . At the same time, hypertension is also the main cause of chronic kidney disease .…”

Section: Introductionmentioning

confidence: 99%

Metabolomics of Artichoke Bud Extract in Spontaneously Hypertensive Rats

Wang

Jiang

Liu³

et al. 2021

ACS Omega

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Hypertension adversely affects the quality of life in humans across modern society. Studies have attributed increased reactive oxygen species production to the pathophysiology of hypertension. So far, a specific drug to control the disease perfectly has not been developed. However, artichoke, an edible vegetable, plays an essential role in treating many diseases due to its potent antioxidant activities. The objective of this study is to evaluate the effect of artichoke bud extract (ABE) on heart tissue metabolomics of hypertensive rats. Spontaneously hypertensive rats and Wistar–Kyoto (WKY) rats were divided into six groups, then exposed to different doses comprising ABE, Enalapril Maleate, or 1% carboxylmethyl cellulose for 4 weeks. Their blood pressures were recorded at 0, 2, 3, and 4 weeks after the start of the test period. Thereafter, all rats were anesthetized, and blood was collected from their cardiac apexes. Then, we measured the levels for 15 kinds of serum biochemical parameters. An established orthogonal partial least square-discriminant analysis model completed the metabolomic analysis. Hypertensive rats in the ABE group exhibited well-controlled blood pressure, relative to those in the model group. Specifically, artichoke significantly lowered serum levels for total protein (TP), albumin (ALB), and uric acid (UA) in the hypertensive rats. This effect involved the action of eight metabolites, including guanine, 1-methylnicotinamide, p-aminobenzoic acid, NAD, NADH, uridine 5′-monophosphate, adenosine monophosphate, and methylmalonic acid. Collectively, these findings suggest that ABE may play a role in affecting oxidative stress and purine, nicotinate, and nicotinamide metabolism.

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“…Indeed, the Mediterranean diet has proven to be beneficial in NAFLD development, mainly due to its high content of polyphenols, vitamins and other molecules with anti-inflammatory and antioxidant effects [242,243]. Specifically, polyphenolic compounds such as resveratrol [244,245] or curcumin [208], or the omega-3 fatty acid, docosahexaenoic acid (DHA) [246], have also shown an improvement in different characteristics of CLD, mainly regarding oxidative stress, inflammation and lipid accumulation, accompanied by the amelioration of HSCs, hepatocytes and KC functions [247,248].…”

Section: Diet and Nutraceuticalsmentioning

confidence: 99%

The Hepatic Sinusoid in Chronic Liver Disease: The Optimal Milieu for Cancer

Gibert‐Ramos

Sanfeliu-Redondo

Aristu-Zabalza³

et al. 2021

Cancers

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The liver sinusoids are a unique type of microvascular beds. The specialized phenotype of sinusoidal cells is essential for their communication, and for the function of all hepatic cell types, including hepatocytes. Liver sinusoidal endothelial cells (LSECs) conform the inner layer of the sinusoids, which is permeable due to the fenestrae across the cytoplasm; hepatic stellate cells (HSCs) surround LSECs, regulate the vascular tone, and synthetize the extracellular matrix, and Kupffer cells (KCs) are the liver-resident macrophages. Upon injury, the harmonic equilibrium in sinusoidal communication is disrupted, leading to phenotypic alterations that may affect the function of the whole liver if the damage persists. Understanding how the specialized sinusoidal cells work in coordination with each other in healthy livers and chronic liver disease is of the utmost importance for the discovery of new therapeutic targets and the design of novel pharmacological strategies. In this manuscript, we summarize the current knowledge on the role of sinusoidal cells and their communication both in health and chronic liver diseases, and their potential pharmacologic modulation. Finally, we discuss how alterations occurring during chronic injury may contribute to the development of hepatocellular carcinoma, which is usually developed in the background of chronic liver disease.

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Oxidative Stress in Chronic Liver Disease and Portal Hypertension: Potential of DHA as Nutraceutical

Cited by 19 publications

References 87 publications

Oxidative Stress Linked Organ Lipid Hydroperoxidation and Dysregulation in Mouse Model of Nonalcoholic Steatohepatitis: Revealed by Lipidomic Profiling of Liver and Kidney

Oxidative Stress Linked Organ Lipid Hydroperoxidation and Dysregulation in Mouse Model of Nonalcoholic Steatohepatitis: Revealed by Lipidomic Profiling of Liver and Kidney

Metabolomics of Artichoke Bud Extract in Spontaneously Hypertensive Rats

The Hepatic Sinusoid in Chronic Liver Disease: The Optimal Milieu for Cancer

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