Oxidative stress in families of type 1 diabetic patients

Matteucci, Elena; Cinapri, V; Quilici, S; Forotti, G; Giampietro, Ottavio

doi:10.1016/s0021-9150(00)80068-4

Cited by 8 publications

(9 citation statements)

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“…This common condition occurs in approximately 7 % (range 1 % -14 % ) of all pregnancies (1) . Hyperglycemia is clearly recognized as the primary culprit in the pathogenesis of diabetic complications, but even maximum glycemic control is associated with the development of complications (2,3) . Hyperglycemia is clearly recognized as the primary culprit in the pathogenesis of diabetic complications, but even maximum glycemic control is associated with the development of complications (2,3) .…”

Section: Introductionmentioning

confidence: 99%

Umbilical cord oxidative stress in infants of diabetic mothers and its relation to maternal hyperglycemia

Sarikabadayi

Aydemir

et al. 2011

Journal of Pediatric Endocrinology and Metabolism

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Aims:There is growing body of evidence that oxidative stress plays an important role in the pathogenesis of diabetes mellitus (DM) and in development of maternal and fetal complications of diabetic pregnancies. The aim of the present study was to investigate total antioxidant capacity (TAC), total oxidant status (TOS), and oxidative stress index (OSI) in infants of diabetic mothers (IDM) and to reveal the infl uence of maternal hyperglycemia on these parameters. Methods: A prospective controlled study was conducted between March 2010 and November 2010. Umbilical cord blood was taken from IDM and controls for TAC and TOS measurement, and OSI was calculated. IDM were divided into two groups, either of mothers treated with insulin during pregnancy or of those treated with a carbohydrate-restricted diet. Results: Thirty-six IDM and 14 infants born to non-diabetic mothers were enrolled. Infants of insulin-treated mothers (group 1) and infants of mothers managed with a carbohydrate-restricted diet (group 2) had signifi cantly higher TOS (p < 0.001 and p = 0.001, respectively) and OSI (p < 0.001 and p = 0.001, respectively) levels compared to controls. However, TAC levels were similar in all three groups. Maternal HbA 1c values were correlated to TOS (p < 0.001, r = 0.694) and OSI (p < 0.001, r = 0.683). Conclusions: Oxidative stress is increased in IDM, and a signifi cant relation exists between the degree of maternal hyperglycemia in pregnancy and oxidative stress in the newborn at birth.

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Section: Introductionmentioning

confidence: 99%

Umbilical cord oxidative stress in infants of diabetic mothers and its relation to maternal hyperglycemia

Sarikabadayi

Aydemir

et al. 2011

Journal of Pediatric Endocrinology and Metabolism

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“…In contrast, hydrogen peroxide suppresses NHE1 promoter activity and increases cell sensitivity to death triggers. These findings have important clinical implications on account of the observed erythrocyte NHE hyperactivity in relation to chronic states of oxidative stress in humans (Matteucci and Giampietro, 2000a; Matteucci and Giampietro, 2001; Matteucci and Giampietro, 2006; Matteucci and Giampietro, 2007a and b). Indeed, RBC NHE activity has been noted as being significantly higher in type 1 diabetes (T1D) family members, independently of the presence of renal disease.…”

Section: Erythrocyte Nhementioning

confidence: 72%

“…Moreover, according to the model proposed by Morré et al (2000), the PMOR maintains NAD + /NADH homeostasis in mitochondrially deficient cells through the regeneration of oxidised pyridine nucleotide to sustain glycolytic ATP production (Fig. 3).…”

Section: Potential Role Of Erythrocyte Pmors As Redox Biomarker In DImentioning

confidence: 99%

Electron Pathways through Erythrocyte Plasma Membrane in Human Physiology and Pathology: Potential Redox Biomarker?

Matteucci

Giampietro

2007

Biomark�Insights

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Erythrocytes are involved in the transport of oxygen and carbon dioxide in the body. Since pH is the influential factor in the Bohr-Haldane effect, pHi is actively maintained via secondary active transports Na+/H+ exchange and HC3−/Cl− anion exchanger. Because of the redox properties of the iron, hemoglobin generates reactive oxygen species and thus, the human erythrocyte is constantly exposed to oxidative damage. Although the adult erythrocyte lacks protein synthesis and cannot restore damaged proteins, it is equipped with high activity of protective enzymes. Redox changes in the cell initiate various signalling pathways. Plasma membrane oxido-reductases (PMORs) are transmembrane electron transport systems that have been found in the membranes of all cells and have been extensively characterized in the human erythrocyte. Erythrocyte PMORs transfer reducing equivalents from intracellular reductants to extracellular oxidants, thus their most important role seems to be to enable the cell respond to changes in intra- and extra-cellular redox environments.So far the activity of erythrocyte PMORs in disease states has not been systematically investigated. This review summarizes present knowledge on erythrocyte electron transfer activity in humans (health, type 1 diabetes, diabetic nephropathy, and chronic uremia) and hypothesizes an integrated model of the functional organization of erythrocyte plasma membrane where electron pathways work in parallel with transport metabolons to maintain redox homeostasis.

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“…However, it is possible that an imbalance in oxidative status precedes the development of DM and is only partly related to insulin treatment and hyperglycemia. This notion is supported by the observation that erythrocytes from nondiabetic parents and siblings of humans with type 1 DM have increased oxidative stress …”

Section: Discussionmentioning

confidence: 85%

Oxidative status of erythrocytes, hyperglycemia, and hyperlipidemia in diabetic cats

Zini

Gabai

Salesov

et al. 2020

Veterinary Internal Medicne

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Background Erythrocytes of diabetic cats have decreased superoxide dismutase activity, possibly indicative of oxidative stress. Hypothesis Erythrocytes of diabetic cats undergo oxidative stress, which is caused by hyperglycemia and hyperlipidemia, and improves with treatment. Animals Twenty‐seven client‐owned cats with diabetes mellitus, 11 matched healthy cats, and 21 purpose‐bred healthy cats. Methods Prospective study. Advanced oxidized protein products, carbonyls (protein oxidation by‐products), and thiols (antioxidants) were quantified in erythrocyte membrane, thiobarbituric acid reactive substances (TBAR, lipid peroxidation by‐products), and thiols in erythrocyte cytoplasm of all cats. Comparison were performed between diabetic and matched healthy cats, between diabetic cats achieving remission or not, and among purpose‐bred cats after 10 days of hyperglycemia (n = 5) or hyperlipidemia (n = 6) versus controls treated with saline (n = 5) or untreated (n = 5). Results Compared with controls, erythrocytes of diabetic cats initially had higher median membrane carbonyls (4.6 nmol/mg total protein [range: 0.1‐37.7] versus 0.7 [0.1‐4.7], P < .001) and lower cytoplasmic TBAR (1.9 nmol/mg [0.5‐2.4] versus 2.4 [1.4‐3.5] P < .001), and thiols (419 nmol/mg [165‐621] versus 633 [353‐824], P < 0.001). After 12‐16 weeks of treatment in diabetic cats, carbonyls decreased by 13% (P < .001), but remained higher (P < .001) and TBAR and thiols lower (P = .02, P < .001) than those in controls. No differences were observed between diabetic cats achieving remission or not, and among purpose‐bred cats. Conclusions and Clinical Importance Diabetes mellitus is associated with increased protein oxidation and reduced antioxidant defenses, which persist during treatment and remission, although mild improvement in protein oxidation occurs. Short‐term hyperglycemia or hyperlipidemia does not cause oxidative stress. The reason for decreased TBAR remains unknown.

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Oxidative stress in families of type 1 diabetic patients

Cited by 8 publications

References 0 publications

Umbilical cord oxidative stress in infants of diabetic mothers and its relation to maternal hyperglycemia

Umbilical cord oxidative stress in infants of diabetic mothers and its relation to maternal hyperglycemia

Electron Pathways through Erythrocyte Plasma Membrane in Human Physiology and Pathology: Potential Redox Biomarker?

Oxidative status of erythrocytes, hyperglycemia, and hyperlipidemia in diabetic cats

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