2018
DOI: 10.1371/journal.pone.0202919
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Oxidative stress in healthy pregnancy and preeclampsia is linked to chronic inflammation, iron status and vascular function

Abstract: BackgroundDuring normal pregnancy, placental oxidative stress (OS) is present during all three trimesters and is necessary to obtain normal cell function. However, if OS reaches a certain level, pregnancy complications might arise. In preeclampsia (PE), a dangerous pregnancy specific hypertensive disorder, OS induced in the ischemic placenta causes a systemic inflammatory response and activates maternal endothelial cells. In this study, we aimed to quantify superoxide concentrations (as a measure of systemic O… Show more

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Cited by 112 publications
(93 citation statements)
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“…The study of histories of mothers of the examined infants showed that 86.5 % of mothers of Group 1 newborns and 67.2% of mothers of Group 2 newborns had obstetric-gynecological complications, which became a significant risk factor for the development of cardiac rhythm disturbances in the groups of examined infants (2=9.641; p<0.002). Obstetric and gynecological pathologies of mothers of newborns of both groups mainly included gestosis of pregnant, the development of which is due to the inability of the adaptive mechanisms of the parent to adequately meet the needs of the developing fetus, resulting in the development of different degrees of severity of perfusion-diffusion insufficiency in the mother-placenta-fetus system [5]. This was confirmed by a rather high percentage of placental malfunctioning in mothers of the examined neonates (17.1 %).…”
Section: Methodsmentioning
confidence: 99%
“…The study of histories of mothers of the examined infants showed that 86.5 % of mothers of Group 1 newborns and 67.2% of mothers of Group 2 newborns had obstetric-gynecological complications, which became a significant risk factor for the development of cardiac rhythm disturbances in the groups of examined infants (2=9.641; p<0.002). Obstetric and gynecological pathologies of mothers of newborns of both groups mainly included gestosis of pregnant, the development of which is due to the inability of the adaptive mechanisms of the parent to adequately meet the needs of the developing fetus, resulting in the development of different degrees of severity of perfusion-diffusion insufficiency in the mother-placenta-fetus system [5]. This was confirmed by a rather high percentage of placental malfunctioning in mothers of the examined neonates (17.1 %).…”
Section: Methodsmentioning
confidence: 99%
“…Oxidative stress (OS) in the placenta plays an important role in the normal metabolism of the placenta. However, the overproduction of reactive oxygen species (ROS) may hamper normal placental functions, giving rise to different disease states such as intrauterine growth retardation (IUGR) or preeclampsia (PE) 100, 101 . Placentas that are oxidatively stressed produce more proinflammatory cytokines such as interleukin‐6 (IL‐6) and tumour necrosis factor‐alpha (TNF‐α).…”
Section: Is Visfatin Involved In the Interrelation Between Oxidativementioning
confidence: 99%
“…As already stated, a combination of both systemic inflammation and OS results in the formation of ROS and RNS, which may subsequently interfere with endothelial function. The disturbance in endothelial homeostasis can in turn result in such pregnancy pathologies as PE or IUGR 100,101,140 . Interestingly, there is an association between visfatin concentration and a vascular dysfunction.…”
Section: Is Visfatin Involved In the Interrelation Between Oxidativementioning
confidence: 99%
“…during the early stage of pregnancy, extravillous cytotrophoblast cells occupy the uterine spiral arterioles and create a low-oxygen environment (3). Thus, the placenta and embryo experience hypoxia-induced oxidative stress as part of the normal physiological process during early pregnancy (4)(5)(6). However, excessive elevated oxidative stress leads to complications such as preeclampsia (Pe), spontaneous abortion and intrauterine growth restriction (7)(8)(9).…”
Section: Introductionmentioning
confidence: 99%
“…The cobalt prevents the degradation of HiF-1α and mimics the HiF-Hre cascade-induced hypoxia (15). another oxidative stressor, sodium nitroprusside (SnP) is a nitric oxide (no) donor and induces a state of oxidative stress via the generation of roS and rnS (5,(23)(24)(25). researchers often treat villi explants or cells with various concentrations of SnP to induce oxidative stress (11,26,27).…”
Section: Introductionmentioning
confidence: 99%