Oxidative Stress in Hemodialysis Pediatric Patients

Shouman, Mohamed; Sabry, Samar; Galal, Rasha; Salama, Emad; Wahby, Aliaa Ahmed; Awadallah, Eman; Selim, Abeer

doi:10.3889/oamjms.2019.859

Cited by 2 publications

(1 citation statement)

References 32 publications

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“…Several results suggest that HD is distinguished by excessive OS state, which results from loss of antioxidants throughout dialysis procedures and accumulation of oxidative products. OS is also triggered by iron infusion, anemia, central venous catheter, bio-incompatible dialyzers, and endotoxin challenge (Liakopoulos et al, 2017;Shouman et al, 2019). Throughout HD, blood exposure to dialyzer membranes and dialysate provoke activation of complement factors, platelets, and polymorphonuclear cells, and subsequently ROS production, within minutes after initiation of HD sessions (Granata, Zaza, & Simone, 2009;Liakopoulos et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

Oxidative stress in hemodialysis patients infected with HIV

Garrido¹

2022

CRCT

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Background: HIV-infected population presents the impaired renal function as a risk factor for death, and comorbid conditions are related in some traits to oxidative stress (OS). Objetive: To analyze the influence of OS in Human Immunodeficiency Virus Infection (HIV) and chronic kidney disease (CKD) by comparing the redox status between HIV patients with and without CKD and HIV hemodialysis patients. Methods: A comparative longitudinal study of the hemodialysis process was developed. The study included 96 individuals divided into four groups namely, supposedly healthy volunteers, patients with HIV infection without renal illnesses, patients with HIV infection and chronic renal disease, and HIV(-) with chronic renal disease. Indexes evaluating redox, hematological, hemochemical, immunologic, and virological aspects were determined. These indexes were also assessed before and after hemodialysis. Results: Viral load, uric acid, creatinine, and urea concentration were significantly (p<0.05) lower after hemodialysis. The two HIV infected groups were significantly different (p<0.05) regarding redox indexes of damage and antioxidant status compared to the group of supposedly healthy volunteers. Significantly increased values (p<0.05) of malondialdehyde, advanced oxidation protein product (AOPP), and peroxidation potential (PP) and significantly lower values glutathione (GSH) (p<0.05) were found after hemodialysis in both groups. In the case of HIV patients, increased values of superoxide dismutase were also found. HIV infected patients under HD tretament exhibited significantly (p<0.05) higher values of AOPP and PP and lower values of GSH than HIV(-) hemodialysis patients after hemodialysis. Conclusion: Oxidative stress occurs in both HIV and CKD conditions, and it is also increased after hemodialysis intervention. Otherwise non-viral control could influence on oxidative status in HIV/CKD patients, that´s why ART affectivities should be monitoring using HIV progression markers. Redox indexes should be diagnosed in HIV hemodialysis patients for treatment and management adjustment.

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Section: Discussionmentioning

confidence: 99%

Oxidative stress in hemodialysis patients infected with HIV

Garrido¹

2022

CRCT

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Impact of anthocyanin on genetic stability in mammary adenocarcinoma-induced mice treated with methotrexate

et al. 2022

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Background Genetic instability leads to genome mutations, changes in nucleotide sequences, rearrangements, and gains or losses of part of the chromosomes. This instability can initiate and develop cancer. This study evaluated genomic stability in methotrexate and anthocyanin-treated mammary adenocarcinoma model. Seventy albino mice were divided into seven groups: negative control, anthocyanin, methotrexate, Ehrlich’s solid tumor; Ehrlich’s solid tumor and methotrexate; Ehrlich’s solid tumor and anthocyanin; and Ehrlich’s solid tumor, methotrexate, and anthocyanin groups. Results Tumor weight and size were evaluated. Serum arylesterase activity was low in all the induced tumors and those treated with anthocyanin, methotrexate, or both. Poly[adenosine diphosphate (ADP)-ribose] polymerase activity was high, and glutathione S-transferase activity was low in the tumors treated with anthocyanin, methotrexate, or both, compared with that of the untreated tumor. There was an increase in DNA damage in the mice with solid tumors and those injected with methotrexate or methotrexate and anthocyanin, compared with that in the untreated mice. Conclusions There was a decrease in genetic instability and DNA damage in the tumor-bearing mice treated with anthocyanin, with a concomitant increase in nuclear poly[adenosine diphosphate (ADP)-ribose] polymerase activity, compared with those of the untreated group. Anthocyanin exerted positive effects in the treatment of mammary adenocarcinoma.

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Oxidative Stress in Hemodialysis Pediatric Patients

Cited by 2 publications

References 32 publications

Oxidative stress in hemodialysis patients infected with HIV

Oxidative stress in hemodialysis patients infected with HIV

Impact of anthocyanin on genetic stability in mammary adenocarcinoma-induced mice treated with methotrexate

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