Oxidative Stress in Obese Postmenopausal Women: An Additive Burden for Atherosclerosis

Uppoor, Rajesh Bhat; Rajesh, Aparna; Srinivasan, Mukund P.; Unnikrishnan, Bhaskaran; Holla, Ramesh

doi:10.7860/jcdr/2015/16467.6868

Cited by 11 publications

(11 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The complications of AS, like coronary artery disease (CAD) and cerebrovascular diseases reduce quality of life and lead to excess morbidity. 1 Epidemiology studies found that the CAD morbidity and mortality rates were significantly higher in postmenopausal women compared with premenopausal women. 2 Unlike younger women, the risk of CAD in older women is higher when there is a decrease in estrogen production, marking the end of the protective effect of endogenous estrogens against CAD.…”

Section: Introductionmentioning

confidence: 99%

Association of Severity of Coronary Lesions with Bone Mineral Density in Postmenopausal Women

Xu¹,

Cheng²,

Zhang³

et al. 2018

Arquivos Brasileiros De Cardiologia

View full text Add to dashboard Cite

BackgroundCoronary artery disease (CAD) and osteoporosis (OP) are common diseases in postmenopausal women. In both cross-sectional and longitudinal epidemiologic studies, low bone mass has been related to increased frequency of CAD. However, available data on the relationship between bone mineral density (BMD) and severity of coronary lesions is limited.ObjectiveTo investigate association between the BMD and severity of coronary lesions assessed by Gensini score in postmenopausal women.MethodsThis study included 122 postmenopausal women who were diagnosed with CAD. These patients were divided into two groups according to the severity of coronary lesions assessed by the Gensini score - patients with mild coronary lesions (Gensini score < 25) and patients with severe coronary lesions (Gensini score ≥ 25). Femoral neck mineral density was measured with dual energy X-ray absorptiometry (DXA).ResultsThe study included postmenopausal women aged 64.31 ± 4.71 years, 85 of whom (69.7%) exhibited severe coronary lesions. Participants with severe coronary lesions had a significantly higher T score than did those with mild coronary lesions at the femoral neck (p < 0.05). The mean T-score was −0.84 ± 1.01 in mild coronary lesions group, −1.42 ± 1.39 in severe coronary lesions group (p < 0.05). Multivariable logistic regression analysis showed that osteopenia-osteoporosis at the Femoral neck (odds ratio 2.73; 95% confidence interval 1.06 to 6.13) was associated with an increased risk of developing severe coronary lesions. The multiple regression model showed that T-scores (b = −0.407, SE = 0.151, p=0.007) were the independent predictors of Gensini score.ConclusionThe relationship between severity of coronary lesions and BMD was significant in postmenopausal women. BMD, a low-cost technique involving minimal radiation exposure, widely used for osteoporosis screening, is a promising marker of severity of coronary lesions.

show abstract

Section: Introductionmentioning

confidence: 99%

Association of Severity of Coronary Lesions with Bone Mineral Density in Postmenopausal Women

Xu¹,

Cheng²,

Zhang³

et al. 2018

Arquivos Brasileiros De Cardiologia

View full text Add to dashboard Cite

show abstract

“…Indeed, few studies exist examining this issue in human population. A previous study showed an increase in oxidative stress in obese postmenopausal women 22 whereas another study demonstrated a decrease in antioxidant defense in older population as compared to young in healthy women and men 23 . Regarding the effect of physical exercise, we found an up-regulation of SOD activity in both groups and this effect was greater in hypertensive group.…”

Section: Discussionmentioning

confidence: 99%

Effect of aerobic exercise training on cGMP levels and blood pressure in treated hypertensive postmenopausal women

Novais

Jarrete

Puga

et al. 2017

Motriz: rev. educ. fis.

View full text Add to dashboard Cite

-The second messenger cGMP has been largely studied as a therapeutic target in a variety of disorders such as erectile dysfunction, arterial hypertension and heart failure. Evidence has shown that cGMP activators are less efficient in estrogen-deficiency animals, but no studies exist involving non-pharmacological approaches on NO/ cGMP signaling pathway in hypertensive postmenopausal women. The aim of this study is to examine NO/cGMP pathway, redox state and blood pressure in trained treated hypertensive (HT) postmenopausal women comparing with normotensive (NT) group. The rationale for that is most of HT patients is encouraged by physician to perform exercise associated with pharmacological treatments. Aerobic exercise training (AET) consisted of 24 sessions, 3 times/week. Parameters were evaluated at baseline and after AET for both groups (HT=28; NT=33).In treated HT group, AET was significantly effective in increasing cGMP concentrations (28%) accompanied by an up-regulation of SOD (97%) and catalase activity (37%). In NT group, we found an increase in SOD activity (58%). Treated HT postmenopausal women were still responsive to AET increasing cGMP levels and up-regulating antioxidant system. It should also be emphasized that these findings provide information on the circulating biomarkers that might delay the developing of cardiovascular events in this particular population.

show abstract

“…Cada día toma más importancia el factor del estrés oxidativo como factor precursor de patologías cardiacas o cáncer. El estrés oxidativo es mayor en la mujer posmenopáusica obesa que aquella con peso normal y que las mujeres que menstrúan normalmente (23) . La terapia hormonal mejora los lípidos y el estrés oxidativo asociado al síndrome metabólico en mujeres posmenopáusicas, cuando es dada desde el inicio del cese de la menstruación (24) .…”

Section: Fisiopatologíaunclassified

Síndrome metabólico en el climaterio

Peralta

2018

Rev peru ginecol obstet.

View full text Add to dashboard Cite

El aumento de la expectativa de vida de las mujeres se ha traducido en incremento de la morbimortalidad en las mujeres mayores, siendo las enfermedades cardiovasculares una de las más prevalentes. Una de las principales causas de morbilidad es el síndrome metabólico. Es necesario orientar al médico y a sus pacientes sobre las consecuencias de esta patología. Son los varones quienes son más tratados, dejando de lado a las mujeres por la errada percepción de que tienen un riesgo cardiovascular bajo. La fisiopatología de la resistencia a la insulina abre un abanico de conocimientos relacionados al incremento de los triglicéridos en sangre y con el mayor aclaramiento del HDL-colesterol por parte del hígado. La obesidad abdominal y la hipertensión arterial completan los elementos de diagnóstico del síndrome metabólico, el cual se hace cuando existen tres de los cinco factores mencionados. Durante la transición menopáusica hay un rápido incremento en la severidad de este síndrome, lo que provoca un aumento del riesgo cardiovascular. En la obesidad hay un estado proinflamatorio inducido por la mayor producción de citoquinas inflamatorias como TNF-alfa, resistina, leptina, por el adipocito obeso, las cuales están vinculadas con la mayoría de las enfermedades crónicas y con el cáncer. En relación a la hipertensión arterial, hay muchas pacientes que desconocen que son portadoras de esta patología y no se hacen tratar, aumentando su riesgo cardiovascular. Por todo lo anterior, el médico ginecólogo debe de familiarizarse con esta patología y tener una actitud activa al respecto con relación a su diagnóstico y manejo.

show abstract

Oxidative Stress in Obese Postmenopausal Women: An Additive Burden for Atherosclerosis

Cited by 11 publications

References 19 publications

Association of Severity of Coronary Lesions with Bone Mineral Density in Postmenopausal Women

Association of Severity of Coronary Lesions with Bone Mineral Density in Postmenopausal Women

Effect of aerobic exercise training on cGMP levels and blood pressure in treated hypertensive postmenopausal women

Síndrome metabólico en el climaterio

Contact Info

Product

Resources

About