Oxidative Stress in Obesity and Metabolic Syndrome in Asian Indians

Abstract

Kratak sadr`aj: Oksidativni stres dovodi se u vezu sa pojedina~nim komponentama metaboli~kog sindroma i povezan je sa razvojem komplikacija u metaboli~kim poreme}ajima. U ovoj studiji upore|eni su nivoi oksidativnog stresa kod gojaznih Indijaca (populaciji sa visokim rizikom za razvoj dijabetesa i kardiovaskularnih poreme}aja) sa i bez metaboli~kog sindroma. Trideset odraslih normotenzivnih, normoglikemi~nih gojaznih ispitanika i 35 odraslih osoba sa metaboli~kim sindromom oba pola sa ITM >23 kg/m 2 pore|eno je sa 30 odraslih zdravih dobrovoljaca sa ITM <23 kg/m 2 . Ispitivani su antropometrijski parametri, krvni pritisak, biohemijski parametri, nivoi hidroperoksida i ukupni antioksidantni kapacitet. U gojaznim grupama sa i bez metaboli~kog sindroma antropometrijski parametri kao {to su obim struka i indeks centralne gojaznosti i aqueous phase hidroperoksidi bili su zna~ajno povi{eni u pore|enju sa kontrolnim subjektima. Grupa sa metaboli~kim sindromom tako|e je imala zna~ajno povi{ene nivoe {e}era u krvi, lipidni profil i nivoe hidroperoksida u pore|enju sa gojaznom ili kontrolnom grupom. Ni u jednoj grupi nije bilo promena u ukupnom antioksidantnom kapacitetu. Odnos trigliceridi/HDL holesterol (>3), kao surogat marker insulinske rezistencije, ukazuje na rezistenciju na insulin u grupi sa metaboli~kim sindromom. Antropometrijski profil, insulinska rezistencija i oksidativni stres prisutni u gojaznosti dalje se razvijaju u metaboli~kom sindromu. Otud rana iden tifikacija osoba sa visokim rizikom na osnovu antro pometrijskih parametara, lipidnog profila, insulinske rezistencije i indeksa oksidativnog stresa mo`e doprineti spre~a -vanju razvoja komplikacija metaboli~kog sindroma.

Antioxidant status in patients with metabolic syndrome as measured by ferric reducing ability of plasma (FRAP) assay

“…27 This is confirmed from the observation of an increased oxidative stress in obese individuals with metabolic syndrome compared with nonobese individuals. 11,28 Findings of the present study support this observation as seen from the positive correlation between WC and MDA (p=0.001) and negative correlation between WC and FRAP (p=0.001) ( Table 3). Hypertension is a cause as well as effect of oxidative stress.…”

“…A likely mechanism for this could be due to the high levels of oxidative stress which deplete endogenous and exogenous pools of antioxidants. Contrary to this view, 6 Marcus et al 11 found no alteration in the total antioxidant capacity was noted in obese Asian Indian metabolic syndrome patients compared to controls which was attributed to be due to a probable increase in serum uric acid levels, one of the components measured by the FRAP assay. We, however, did not find any change in uric acid levels in our metabolic syndrome patients compared to controls (p=0.100).…”

“…7 Also, recently it has been found that there exists a racial difference in the levels of oxidative stress in patients with metabolic syndrome. 8 However, there are very few publications [9][10][11] which have studied the total antioxidant capacity as an index of antioxidant defense in patients with metabolic syndrome with conflicting results. The present study was thus taken up to evaluate the oxidative stress including total antioxidant status in patients with metabolic syndrome.…”

The Impact of Senile Cataract Maturity on Blood Oxidative Stress Markers and Glutathione-Dependent Antioxidants: Relations with Lens Variables

“…Plasma GR and GPx activities were in our study evidently related to the maturation stage of SC, thus their synergistic reduction could also be an epiphenomenon of the disease severity. Physical inactivity, for example, which often accompanies the greater visual disability, has been shown to decrease both kidney and lens GPx and GR in experimental models, as well as erythrocytes GR in healthy elderly people (29)(30)(31)(32)(33)(34). Plasma GPx and GR were in our study well correlated with correspondent lens enzymes in either stage of SC, suggesting that they may serve as lens surrogate markers.…”

Lipoproteins and other Risk Factors for Cardiovascular Disease in a Student Population

“…Today, we have convincing evidence that atherosclerotic changes start in early childhood and the period of adolescence, and according to some authors as early as in the fetal period (5,6). Primary prevention includes modification of risk factors in the prevention of coronary atherosclerosis, atherosclerosis of other localization and ischemic heart disease (IHD) (7).…”