Oxidative stress in obesity-associated hepatocellular carcinoma: sources, signaling and therapeutic challenges

Brahma, Manoja K.; Gilglioni, Eduardo Hideo; Zhou, Lang; Trépo, Eric; Chen, Pengyu; Gurzov, Esteban Nicolas

doi:10.1038/s41388-021-01950-y

Cited by 44 publications

(31 citation statements)

References 122 publications

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“…Abnormal antioxidative response via aberrant Kelch-like ECH-associated protein 1 (Keap1)- nuclear factor erythroid 2-related factor 2 (NRF2) signaling is a common event in the progression of HCC [ 96 ]. TRIM25 promotes ubiquitin degradation of Keap1, therefore over-activating NRF2 to alleviate oxidative stress and reduce apoptosis in HCC [ 97 ].…”

Section: Effects Of Trim Proteins On Hallmarks Of Carcinogenesismentioning

confidence: 99%

TRIM proteins in hepatocellular carcinoma

Pan

Huang

et al. 2022

J Biomed Sci

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The tripartite motif (TRIM) protein family is a highly conserved group of E3 ligases with 77 members known in the human, most of which consist of a RING-finger domain, one or two B-box domains, and a coiled-coil domain. Generally, TRIM proteins function as E3 ligases to facilitate specific proteasomal degradation of target proteins. In addition, E3 ligase independent functions of TRIM protein were also reported. In hepatocellular carcinoma, expressions of TRIM proteins are both regulated by genetic and epigenetic mechanisms. TRIM proteins regulate multiple biological activities and signaling cascades. And TRIM proteins influence hallmarks of HCC. This review systematically demonstrates the versatile roles of TRIM proteins in HCC and helps us better understand the molecular mechanism of the development and progression of HCC.

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Section: Effects Of Trim Proteins On Hallmarks Of Carcinogenesismentioning

confidence: 99%

TRIM proteins in hepatocellular carcinoma

Pan

Huang

et al. 2022

J Biomed Sci

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“…Many studies have reported that the levels of these metabolites are increased in obese people 31 , 32 . Obesity has been found to be a risk factor for HCC 33 , 34 . These metabolites are likely to inhibit the activity of PANK1, thus activating the Wnt/β-catenin signaling pathway and promoting the occurrence and progression of HCC.…”

Section: Discussionmentioning

confidence: 99%

Pantothenate Kinase 1 Inhibits the Progression of Hepatocellular Carcinoma by Negatively Regulating Wnt/β-catenin Signaling

Zi¹,

Gao²,

Wang³

et al. 2022

Int. J. Biol. Sci.

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Hyperactivation of Wnt/β-catenin signaling has been reported in hepatocellular carcinoma (HCC). However, the mechanisms underlying the hyperactivation of Wnt/β-catenin signaling are incompletely understood. In this study, Pantothenate kinase 1 (PANK1) is shown to be a negative regulator of Wnt/β-catenin signaling. Downregulation of PANK1 in HCC correlates with clinical features. Knockdown of PANK1 promotes the proliferation, growth and invasion of HCC cells, while overexpression of PANK1 inhibits the proliferation, growth, invasion and tumorigenicity of HCC cells. Mechanistically, PANK1 binds to CK1α, exerts protein kinase activity and cooperates with CK1α to phosphorylate N-terminal serine and threonine residues in β-catenin both in vitro and in vivo. Additionally, the expression levels of PANK1 and β-catenin can be used to predict the prognosis of HCC. Collectively, the results of this study highlight the crucial roles of PANK1 protein kinase activity in inhibiting Wnt/β-catenin signaling, suggesting that PANK1 is a potential therapeutic target for HCC.

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“…Therefore, highly reactive molecules react with DNA bases, resulting in pro-mutagenic DNA adducts. Oxidative stress has been shown to contribute to cell migration, invasion, and metastasis in hepatocellular carcinoma [ 43 , 44 , 45 ].…”

Section: Liver and Oxidative Stressmentioning

confidence: 99%

Oxidative Stress in Chronic Hepatitis B—An Update

Popa

2022

Microorganisms

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In recent years, the role of oxidative stress has been investigated in an increasing number of infections. There is a close link between the inflammation that accompanies infections and oxidative stress. Excessive reactive oxygen species induce harmful effects on cell components, including lipids, proteins, and nucleic acids. A growing body of evidence attests to the role of oxidative stress in the pathogenesis of viral liver infections, especially in hepatitis C virus (HCV) infection. Regarding hepatitis B virus (HBV) infection, the data are limited, but important progress has been achieved in recent years. This review presents the latest advances pertaining to the role of the oxidative stress byproducts in the pathogenesis of chronic hepatitis B, constituting a source of potential new markers for the evaluation and monitoring of patients with chronic hepatitis B.

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Oxidative stress in obesity-associated hepatocellular carcinoma: sources, signaling and therapeutic challenges

Cited by 44 publications

References 122 publications

TRIM proteins in hepatocellular carcinoma

TRIM proteins in hepatocellular carcinoma

Pantothenate Kinase 1 Inhibits the Progression of Hepatocellular Carcinoma by Negatively Regulating Wnt/β-catenin Signaling

Oxidative Stress in Chronic Hepatitis B—An Update

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