Oxidative stress in patients with primary insomnia

Güleç, Mustafa; Özkol, Halil; Selvı, Yavuz; Tülüce, Yasin; Aydın, Adem; Beşiroğlu, Lütfullah; Özdemir, Pınar Güzel

doi:10.1016/j.pnpbp.2012.02.011

Cited by 107 publications

(68 citation statements)

References 53 publications

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“…For example, levels of thiobarbituric acid reactive substances were elevated in postmenopausal women with insomnia, although blood concentrations of catalase, superoxide dismutase, and glutathione were found to be normal (Hachul de Campos et al, 2006). In an investigation on participants with primary insomnia, significantly lower GSH-Px (selenium-containing antioxidant enzyme) activity and higher MDA levels were found compared with controls (Gulec et al, 2012). Further evidence of a relationship between sleep and oxidative stress is provided by a study revealing increased levels of myeloperoxidase-modified low-density lipoprotein following five nights of sleep restriction in healthy males (Boudjeltia et al, 2011).…”

Section: Sleep and Its Effect On Oxidative Stressmentioning

confidence: 99%

A review of lifestyle factors that contribute to important pathways associated with major depression: Diet, sleep and exercise

Lopresti

Hood

Drummond

2013

Journal of Affective Disorders

529

412

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Research on major depression has confirmed that it is caused by an array of biopsychosocial and lifestyle factors. Diet, exercise and sleep are three such influences that play a significant mediating role in the development, progression and treatment of this condition. This review summarises animal and human-based studies on the relationship between these three lifestyle factors and major depressive disorder, and their influence on dysregulated pathways associated with depression, namely neurotransmitter processes, immuno-inflammatory pathways, hypothalamic-pituitary-adrenal (HPA) axis disturbances, oxidative stress and antioxidant defence systems, neuroprogression, and mitochondrial disturbances. Increased attention in future clinical studies on the influence of diet, sleep and exercise on major depressive disorder and investigations of their effect on physiological processes will help to expand our understanding and treatment of major depressive disorder. Mental health interventions, taking into account the bidirectional relationship between these lifestyle factors and major depression are also likely to enhance the efficacy of interventions associated with this disorder.

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Section: Sleep and Its Effect On Oxidative Stressmentioning

confidence: 99%

A review of lifestyle factors that contribute to important pathways associated with major depression: Diet, sleep and exercise

Lopresti

Hood

Drummond

2013

Journal of Affective Disorders

529

412

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“…This is characterised by sleep onset difficulties, sleep-disordered breathing, and frequent night-time awakenings (Hvolby 2014;Sedky et al 2014). While there continues to be uncertainty about the direction of this ADHD-sleep relationship, it has been confirmed that sleep problems are associated with increased O&NS (Boudjeltia et al 2011;Gulec et al 2012), thereby presenting an additional contributory cause for the increased O&NS observed in ADHD.…”

Section: Potential Causes Of Oandns In Adhdmentioning

confidence: 99%

Oxidative and nitrosative stress in ADHD: possible causes and the potential of antioxidant-targeted therapies

Lopresti

2015

ADHD Atten Def Hyp Disord

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Attention deficit hyperactivity disorder (ADHD) has a complex etiology although theories associated with disturbances in dopaminergic and noradrenergic activity are most commonly cited.The importance of these catecholamines in ADHD is supported by its effective treatment utilising stimulant and non-stimulant medications that modify their activity. Recently there has been interest in oxidative and nitrosative stress (O&NS) in ADHD and its potential to contribute to this condition. In this article, research investigating O&NS in ADHD is reviewed and its impact on catecholaminergic activity and neurological structure is discussed. Lifestyle, environmental, ADHD is most commonly treated with stimulant medications such as methylphenidate and amphetamines, non-stimulants such as atomoxetine, and alpha2-adrenergic agonists such as clonidine and guanfacine. Through their effects on dopamine and noradrenaline transporters, stimulants inhibit the reuptake of dopamine and noradrenaline, thereby increasing the extracellular levels of these neurotransmitters. These stimulants also inhibit monoamine oxidase, the enzyme that metabolises these catecholamines (Wilens et al. 2011). Atomoxetine works as a selective reuptake inhibitor of noradrenaline leading to its increased extracellular concentration (Garnock- Jones and Keating 2009).While effective, these medications are associated with several adverse effects. These include loss of appetite, growth delay and sleep disturbances (Cortese et al. 2013). It is important to note that despite their widely accepted short-term efficacy, the long-term effectiveness of pharmacological treatments on social, educational and occupational functioning in people with ADHD continues to be debated (Huang and Tsai 2011;Langberg and Becker 2012;Nijmeijer et al. 2008). On a positive note, recent analyses using the Swedish national registrar suggests that long-term stimulant use in people with ADHD is associated with reduced rates of substance use, criminality, and serious traffic accidents (Chang et al. 2014a;Chang et al. 2014b;Lichtenstein et al. 2012).Despite wide appreciation of catecholaminergic theories associated with ADHD, there has been increased research into other biological mechanisms associated with ADHD. For example, in psychiatry there has been interest in immune-inflammatory pathways and oxidative and nitrosative stress (O&NS). In particular, it has been confirmed through recent meta-analyses that depression is Increased O&NS has also been found in bipolar disorder (Andreazza et al. 2008;Brown et al. 2014),

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“…3 Research has demonstrated an association between sleep/wake disruption and flattened diurnal cortisol rhythms in women awaiting breast cancer surgery. 12 Furthermore, in breast cancer patients undergoing chemotherapy, poor sleep quality has been associated with increases in inflammatory cytokines (interleukin-6 and interleukin-1 receptor agonist) and C-reactive protein.…”

Section: Discussionmentioning

confidence: 99%

“…Telomere shortening occurs via normal aging but can be accelerated through exposure to oxidative stress. In the only study to date examining the association between sleep and oxidative stress, Gulec et al 3 demonstrated that patients with primary insomnia have significantly higher levels of oxidative stress indicators and lower levels of free radical scavenging anti-oxidants. This suggests a potential link between sleep, oxidative stress, and TL as a pathway to health or disease.…”

mentioning

confidence: 99%

A Nested Case-Controlled Comparison of Telomere Length and Psychological Functioning in Breast Cancer Survivors with and without Insomnia Symptoms

Garland

Palmer²,

Donelson³

et al. 2014

Rejuvenation Research

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The ability to achieve sufficient restorative sleep is important in the maintenance of physical and mental health; however, disturbed sleep and insomnia symptoms are a common experience among women with breast cancer. In non-cancer populations, insufficient sleep quantity and quality has been associated with shortened telomere length (TL), a measure of accumulated cellular damage and human aging. This feasibility study compared TL in women previously diagnosed with breast cancer with clinically significant insomnia symptoms (n = 70) to an age-and body mass index (BMI)-matched comparison group (n = 70) of breast cancer survivors. Women with significant insomnia symptoms had higher levels of unemployment compared to women without insomnia. TL was positively skewed and shorter in the insomnia group (Median = 6.000, S = 1.000, standard error [SE] = 0.287) than the control group (Median = 6.195, S = -0.269, SE = 0.287); however, this was not significant ( p = 0.29). Women with insomnia also reported significantly higher levels of depression ( p < 0.001), anxiety ( p < 0.001), and fatigue ( p < 0.001). This study provides the first measure of effect size and variability of TL in women with breast cancer and highlights the need for larger sample sizes to investigate the impact of insomnia and co-morbid symptom distress on cellular aging.

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Oxidative stress in patients with primary insomnia

Cited by 107 publications

References 53 publications

A review of lifestyle factors that contribute to important pathways associated with major depression: Diet, sleep and exercise

A review of lifestyle factors that contribute to important pathways associated with major depression: Diet, sleep and exercise

Oxidative and nitrosative stress in ADHD: possible causes and the potential of antioxidant-targeted therapies

A Nested Case-Controlled Comparison of Telomere Length and Psychological Functioning in Breast Cancer Survivors with and without Insomnia Symptoms

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