Oxidative stress in patients with refractory temporal lobe epilepsy and mesial temporal sclerosis: Possible association with major depressive disorder?

Filho, Gerardo Maria de Araújo; Martins, Denise Poltronieri; Lopes, A. M.; Brait, Beatriz de Jesus; Furlan, Ana Eliza Romano; Oliveira, Camila Ive Ferreira; Marques, Lúcia Helena Neves; Souza, Dorotéia Rossi Silva; Almeida, Eduardo Alves de

doi:10.1016/j.yebeh.2017.12.025

Cited by 17 publications

(12 citation statements)

References 50 publications

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“…Patients with epilepsy have a three-fold risk for psychiatric comorbidities compared to the general population [2]. Almost 20-22% of patients with epilepsy suffer from depression [2][3][4][5][6][7], while its prevalence may reach 60% in patients with temporal lobe epilepsy [8,9].…”

Section: Introductionmentioning

confidence: 99%

Depression and quality of life in patients with epilepsy in Northwest Greece

Siarava

Hyphantis

Katsanos

et al. 2019

Seizure

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The purpose of the present study was to compare depression and QoL between patients with epilepsy and healthy controls, evaluating potentially related factors to depression and QoL in patients with epilepsy in Northwest Greece. Methods: A case study was conducted in adult patients with epilepsy followed up at the University Hospital of Ioannina and in healthy controls. The Patient Health Questionnaire (PHQ-9) for depression's severity evaluation, the WHOQOL-BREF questionnaire for the QoL estimation and the Adverse Event Profile (AEP) questionnaire for the Antiepileptic Drugs (AEDs) adverse effects assessment were used. Results: Seventy patients with epilepsy and 70 controls were recruited. The PHQ-9 score was higher in patients compared to controls and slightly higher than reported in patients with epilepsy. PHQ-9 was significantly associated with the AEP score. Our patients had a poorer QoL compared to controls. The level of education, the AEP and the PHQ-9 scores were associated to QoL, the last two being the most powerful predictors of QoL. Conclusion: Patients with epilepsy in Northwest Greece had higher rates of depression than reported in patients with epilepsy and poorer QoL compared to controls. The adverse effects of AEDs were related to depression in our study, while the adverse effects of AEDs and depression were more powerful predictors of QoL compared to demographics and other characteristics of epilepsy.

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Section: Introductionmentioning

confidence: 99%

Depression and quality of life in patients with epilepsy in Northwest Greece

Siarava

Hyphantis

Katsanos

et al. 2019

Seizure

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“…Furthermore, in this series MDA levels showed high sensibility and specificity, indicating discriminatory power and a potential prognostic tool for oxidative stress in patients with schizophrenia, according to another study (Pawar and Abhang, 2017). In contrast, similar values of TEAC, which correspond to the antioxidant capacity and protection against free radicals and reactive oxygen species (Gilca et al, 2014;Filho et al, 2018), were showed in all groups, but reduced level in patients using antipsychotics was also reported (Gilca et al, 2014).…”

Section: Discussionmentioning

confidence: 80%

“…Oxidative stress, an imbalance between reactive oxygen species and antioxidant agents, can be measured also by biomarkers such as malondialdehyde (MDA), a byproduct of lipid peroxidation that impairs the functioning of neuronal cells (Emiliani et al, 2014;Liencres et al, 2014;Pawar and Abhang, 2017;Zheng et al, 2019). Additionally, the competence of antioxidant components can be evaluated by the trolox equivalent antioxidant capacity (TEAC) (Gilca et al, 2014;Filho et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Research Article Genetic and biochemical biomarkers related to oxidative stress in patients with schizophrenia

Forner¹,

Andreguetto²,

Lopes³

et al. 2019

Genet. Mol. Res.

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We evaluated the association of glutathione Stransferase polymorphisms (GSTT1 and GSTM1) and oxidative stress biomarkers in patients with schizophrenia. A total of 162 subjects were studied: 53 had schizophrenia (Total Study Group-TSG), and 109 without the disorder (Total Control Group-TCG). To analyze oxidative stress, TSG was distributed into treatment-responsive schizophrenia (N = 26) and treatment-resistant (N = 27) versus

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“…Previously, a significant association between suicidal behaviors and oxidative toxicity including elevated AOPP levels was reported [76]. Moreover, de Araujo Filho et al [31] observed that MDA levels were significantly increased in comorbid TLE patients and depression. Nevertheless, in our study, mood disorders due to TLE with depressive symptoms and anxiety disorders due to TLE are accompanied by somewhat lowered MDA levels, while anxiety disorders due to TLE also show a lower lowered oxidative stress toxicity index than patients with TLE without these comorbidities.…”

Section: Discussionmentioning

confidence: 92%

“…The association between redox status and psychosis is more complex, with no or minimal changes being observed in first-episode psychosis [28,29] and in chronic schizophrenia [30], although deficit, but not non-deficit schizophrenia, is accompanied by increased levels of AOPP and lipid hydroperoxides (LOOH), but not MDA, and lowered levels of -SH groups and TRAP (Maes et al, in preparation). A recent study showed that MDA levels were significantly higher in TLE patients with depression than in those without [31], suggesting that this comorbidity may increase oxidative stress toxicity.…”

Section: Introductionmentioning

confidence: 99%

Increased Oxidative Stress Toxicity and Lowered Antioxidant Defenses in Temporal Lobe Epilepsy and Mesial Temporal Sclerosis: Associations with Psychiatric Comorbidities

Maes¹,

Supasitthumrong²,

Limotai³

et al. 2020

Preprint

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Oxidative stress toxicity (OSTOX), as well as lowered antioxidant defenses (ANTIOX), play a role in temporal lobe epilepsy (TLE). Nevertheless, the associations between OSTOX/ANTIOX and psychiatric comorbidities in TLE are largely unknown.Thus, this study examines plasma malondialdehyde (MDA), lipid hydroperoxides (LOOH), advanced oxidation protein products (AOPP), nitric oxide metabolites (NOx), total radical trapping antioxidant parameter (TRAP) and sulfhydryl (-SH) groups in Depression due to TLE (n=25); Anxiety Disorders due to TLE (n=27); Psychotic Disorder due to TLE (n=25); “pure TLE” (n=27); and healthy controls (n=40).TLE and mesial temporal sclerosis (MTS) were characterized by significant increases in OSTOX (MDA, AOPP, LOOH) and lowered ANTIOX (-SH groups, TRAP). The discrimination of pure TLE from controls yielded a significant area under the ROC curve for MDA (0.999), AOPP (0.851), -SH groups (0.899) and the OSTOX/ANTIOX ratio (0.996). Seizure frequency is significantly associated with increased MDA and lowered LOOH and NOx levels. Increased MDA was associated with the severity of depressive and physiosomatic symptoms, whilst increased AOPP levels predicted suicidal ideation. Depression and anxiety disorders co-occurring with TLE showed significantly lower MDA levels than TLE without any comorbidities. The psychotic and negative symptoms of TLE are associated with increased MDA levels and excitation with increased LOOH and lowered TRAP levels.These results indicate that oxidative stress toxicity especially protein oxidation and aldehyde formation coupled with lowered -SH groups play a key role in the pathophysiology of TLE/MTS. Increased aldehyde formation also impacts psychopathology, psychosis, as well as negative and depressive symptoms.

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Oxidative stress in patients with refractory temporal lobe epilepsy and mesial temporal sclerosis: Possible association with major depressive disorder?

Cited by 17 publications

References 50 publications

Depression and quality of life in patients with epilepsy in Northwest Greece

Depression and quality of life in patients with epilepsy in Northwest Greece

Research Article Genetic and biochemical biomarkers related to oxidative stress in patients with schizophrenia

Increased Oxidative Stress Toxicity and Lowered Antioxidant Defenses in Temporal Lobe Epilepsy and Mesial Temporal Sclerosis: Associations with Psychiatric Comorbidities

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