Oxidative stress in patients with chronic heart failure and type 2 diabetes mellitus

Arzamastseva, N. E.; Ланкин, В. З.; Konovalova, G. G.; Tikhaze, A. K.; Агеев, Ф Т; Lapina, Y.V.; Narusov, O Yu; Mareev, V Yu; Belenkov, Yu. N.

doi:10.1007/s10517-007-0052-8

Cited by 10 publications

(4 citation statements)

References 8 publications

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“…Previously it was demonstrated that oxidative stress under hyperglycemic conditions promotes lipid infiltration to the vascular wall caused by increased oxidation of lipoproteins [12] .…”

Section: Discussionmentioning

confidence: 99%

Proinflammatory monocyte polarization in type 2 diabetes mellitus and coronary heart disease

Nikiforov¹,

Galstyan²,

Недосугова³

et al. 2017

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How to cite this article: Nikiforov NG, Galstyan KO, Nedosugova LV, Elizova NV, Kolmychkova KI, Ivanova EA. Proinflammatory monocyte polarization in type 2 diabetes mellitus and coronary heart disease. Vessel Plus 2017;1:192-5.Aim: Type 2 diabetes mellitus (T2DM) is associated with rapid progression of atherosclerosis. There is no doubt that inflammation is involved in atherogenesis. Recent studies showed the relationship between the development of atherosclerotic plaque formation and the amount of pro-inflammatory (M1) activated macrophages in situ. Methods: The authors studied the ability of circulating monocytes isolated from patients with diabetes (n = 28), coronary heart disease (CHD) (n = 27) and healthy subjects (n = 50) to be activated into M1 phenotype in vitro. Results: Increased levels of basal and stimulated secretion of tumor necrosis factor alpha (TNF-α) was observed in diabetic patients compared with healthy subjects. On the contrary, in patients with CHD, decreased secretion of the pro-inflammatory cytokine, TNF-α, was found. A direct correlation between glycated hemoglobin (HbA1c) levels in T2DM patients and basal secretion of TNF-α from monocytes was observed. Conclusion: The authors found diametrically different responses of monocytes from T2DM and CHD under pro-inflammatory stimuli. Key words:Type 2 diabetes mellitus, coronary heart disease, M1/M2 monocyte polarization, oxidative stress, atherosclerosis, inflammatory ABSTRACTArticle history:

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“…Previously it was demonstrated that oxidative stress under hyperglycemic conditions promotes lipid infiltration to the vascular wall caused by increased oxidation of lipoproteins [12] .…”

Section: Discussionmentioning

confidence: 99%

Proinflammatory monocyte polarization in type 2 diabetes mellitus and coronary heart disease

Nikiforov¹,

Galstyan²,

Недосугова³

et al. 2017

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“…Several groups have reported increased lipid peroxidation and carbonyl stress in the cardiovascular system of diabetic patients (Arzamastseva et al, 2007; Anderson et al, 2009; Annadurai et al, 2014). Studies in diabetic rat heart show that HNE binds preferentially to cysteine > histidine > lysine residues in the mitochondria (LoPachin et al, 2009).…”

Section: Cardio-metabolic Disease and Oxidative Stress In Striated Mumentioning

confidence: 99%

The â€œGoldilocks Zoneâ€ from a redox perspectiveâ€”Adaptive vs. deleterious responses to oxidative stress in striated muscle

et al. 2014

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Consequences of oxidative stress may be beneficial or detrimental in physiological systems. An organ system's position on the “hormetic curve” is governed by the source and temporality of reactive oxygen species (ROS) production, proximity of ROS to moieties most susceptible to damage, and the capacity of the endogenous cellular ROS scavenging mechanisms. Most importantly, the resilience of the tissue (the capacity to recover from damage) is a decisive factor, and this is reflected in the disparate response to ROS in cardiac and skeletal muscle. In myocytes, a high oxidative capacity invariably results in a significant ROS burden which in homeostasis, is rapidly neutralized by the robust antioxidant network. The up-regulation of key pathways in the antioxidant network is a central component of the hormetic response to ROS. Despite such adaptations, persistent oxidative stress over an extended time-frame (e.g., months to years) inevitably leads to cumulative damages, maladaptation and ultimately the pathogenesis of chronic diseases. Indeed, persistent oxidative stress in heart and skeletal muscle has been repeatedly demonstrated to have causal roles in the etiology of heart disease and insulin resistance, respectively. Deciphering the mechanisms that underlie the divergence between adaptive and maladaptive responses to oxidative stress remains an active area of research for basic scientists and clinicians alike, as this would undoubtedly lead to novel therapeutic approaches. Here, we provide an overview of major types of ROS in striated muscle and the divergent adaptations that occur in response to them. Emphasis is placed on highlighting newly uncovered areas of research on this topic, with particular focus on the mitochondria, and the diverging roles that ROS play in muscle health (e.g., exercise or preconditioning) and disease (e.g., cardiomyopathy, ischemia, metabolic syndrome).

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“…The results show that antioxidant capacity in terms of the CUPRAC assay were significantly higher in both phases of roasted seed extracts compared to those of raw seed extracts (p<0.05), resulting also in a significantly higher antioxidant capacity in roasted compared to those of raw seeds in total (p<0.05). Oxidative stress plays an important role in ageing and the pathogenesis of chronic diseases such as atherosclerosis and diabetes (Arzamastseva et al, 2007;Giacco & Brownlee, 2010). Many epidemiological studies suggest that consumption of a fruit-and vegetable-rich diet inversely correlates with the risk of chronic diseases.…”

Section: Cuprac Assaymentioning

confidence: 99%

In vitro health beneficial activities of Pumpkin seeds from Cucurbita moschata cultivated in Lemnos

Sakka

Karantonis

2015

IJFS

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Pumpkin seeds are commonly consumed in Greece. Although Cucurbita moschata is locally grown in Lemnos and is traditionally used in pumpkin pies, the seeds are currently discarded after consumption of the fruit flesh. The aim of the present study was to investigate the nutritional functionality of pumpkin seeds from Cucurbita moschata grown in Lemnos. Cucurbita moschatas' seeds, raw or roasted, were appropriately extracted and the results are presented for raw versus (vs) roasted seed extracts. The phenolic content was expressed as µg gallic acid/g of seeds according to Folin-Ciocalteau assay (370.3 ± 19.1 vs 551.0 ± 22.0). Antioxidant capacity was expressed as equivalent amount for 50% scavenging in mg of seeds for DPPH (50.03 ± 5.91 vs 25.82 ± 6.77) and ABTS (17.85 ± 0.77 vs 12.77 ± 0.76) assays, and as µmol of trolox/g of seeds for FRAP (1.19 ± 0.05 vs 2.50 ± 0.23) and CUPRAC (2.13 ±0.11 vs 3.25 ± 0.06) assays. Anti-inflammatory/antithrombotic and anti-diabetic activities were expressed as mg of seeds for 50% inhibition of platelet activating factor (0.62 vs 0.15) and as µg of seeds for 25% inhibition of alpha-glycosidase (40.0 vs 61.0) activities respectively. Moreover, anti-atherogenic activity was expressed as the % increase in lag time of human plasma oxidation (62.7 versus 163.2) Raw and roasted pumpkin seed extracts exert anti-oxidant, anti-thrombotic/anti-inflammatory, antiatherogenic and antidiabetic activities. Cucurbita moschata seeds may represent a novel opportunity for development of functional foods, with a local interest in Lemnos that would contribute also to the regional public health improvement.

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Oxidative stress in patients with chronic heart failure and type 2 diabetes mellitus

Cited by 10 publications

References 8 publications

Proinflammatory monocyte polarization in type 2 diabetes mellitus and coronary heart disease

Proinflammatory monocyte polarization in type 2 diabetes mellitus and coronary heart disease

The â€œGoldilocks Zoneâ€ from a redox perspectiveâ€”Adaptive vs. deleterious responses to oxidative stress in striated muscle

In vitro health beneficial activities of Pumpkin seeds from Cucurbita moschata cultivated in Lemnos

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Oxidative stress in patients with chronic heart failure and type 2 diabetes mellitus

Cited by 10 publications

References 8 publications

Proinflammatory monocyte polarization in type 2 diabetes mellitus and coronary heart disease

Proinflammatory monocyte polarization in type 2 diabetes mellitus and coronary heart disease

The â€œGoldilocks Zoneâ€ from a redox perspectiveâ€”Adaptive vs. deleterious responses to oxidative stress in striated muscle

In vitro health beneficial activities of Pumpkin seeds from Cucurbita moschata cultivated in Lemnos

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The â€œGoldilocks Zoneâ€ from a redox perspectiveâ€”Adaptive vs. deleterious responses to oxidative stress in striated muscle