Oxidative Stress in Preretinopathic Diabetes Subjects and Antioxidants

Nebbioso, Marcella; Federici, Matteo; Rusciano, Dario; Evangelista, Mariasilvia; Pescosolido, Nicola

doi:10.1089/dia.2011.0172

Cited by 45 publications

(35 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Vitamin E is shown to ameliorate retinal hemodynamic abnormalities in diabetic patients [98], and oral administration of α-lipoic acid with genistein and vitamins for 30 days is shown to improve ERG oscillatory potential in patients with proliferative diabetic retinopathy [99]. Antioxidant properties containing calcium dobesilate and A C C E P T E D M A N U S C R I P T ACCEPTED MANUSCRIPT 25 pycnogenol reduce the progression of diabetic retinopathy [100,101].…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Oxidative stress, mitochondrial damage and diabetic retinopathy

Kowluru

Mishra

2015

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Diseas

280

246

View full text Add to dashboard Cite

Diabetes has emerged as an epidemic of the 21st century, and retinopathy remains the leading cause of blindness in young adults and the mechanism of this blinding disease remains evasive. Diabetes-induced metabolic abnormalities have been identified, but a causal relationship between any specific abnormality and the development of this multi-factorial disease is unclear. Reactive oxygen species (ROS) are increased and the antioxidant defense system is compromised. Increased ROS result in retinal metabolic abnormalities, and these metabolic abnormalities can also produce ROS. Sustained exposure to ROS damages the mitochondria and compromises the electron transport system (ETC), and, ultimately, the mitochondrial DNA (mtDNA) is damaged. Damaged mtDNA impairs its transcription, and the vicious cycle of ROS continues to propagate. Many genes important in generation and neutralization of ROS are also epigenetically modified further increasing ROS, and the futile cycle continues to fuel in. Antioxidants have generated beneficial effects in ameliorating retinopathy in diabetic rodents, but limited clinical studies have not been encouraging. With the ongoing use of antioxidants for other chronic diseases, there is a need for a controlled trial to recognize their potential in ameliorating the development of this devastating disease.

show abstract

Section: Accepted Manuscriptmentioning

confidence: 99%

Oxidative stress, mitochondrial damage and diabetic retinopathy

Kowluru

Mishra

2015

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Diseas

280

246

View full text Add to dashboard Cite

show abstract

“…In humans, a clinical trial with ALA supplementation failed to demonstrate prevention of diabetic macular oedema [57]. However, another study including diabetic subjects who had not yet developed retinopathy and who received ALA in combination with other antioxidants showed improvements in electroretinogram [58].…”

Section: Mechanism Of Action In Other Diabetic Complicationsmentioning

confidence: 99%

Efficacy of α-lipoic acid in diabetic neuropathy

Παπάνας

Ziegler

2014

Expert Opinion on Pharmacotherapy

169

View full text Add to dashboard Cite

ALA is a valuable therapeutic option for diabetic neuropathy. When compared with currently licensed analgesic drugs, it is better tolerated, has a more rapid onset of action, and improves paraesthesiae, numbness, sensory deficits, and muscle strength in addition to neuropathic pain. In clinical practice, ALA may be chosen in patients with early neuropathic deficits and symptoms, in whom clinical improvement is more likely. ALA should also be considered when comorbidities render other analgesics less appropriate or in the presence of cardiovascular autonomic neuropathy.

show abstract

“…L-carnitine, which facilitates the transport of long chain fatty acids into mitochondria, improves insulin sensitivity in insulin-resistant patients, suggesting a possible beneficial effect on the progression of diabetic retinopathy [55]. Recently, a preliminary human study suggested that α-lipoic acid treatment improved the electroretinogram results in patients with diabetic retinopathy [56]. However, the treatment period was only 4weeks so the study could not reveal long-term results.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Lithospermic Acid, an Antioxidant, on Development of Diabetic Retinopathy in Spontaneously Obese Diabetic Rats

Jin

Wang

et al. 2014

PLoS ONE

View full text Add to dashboard Cite

BackgroundLithospermic acid B (LAB), an active component isolated from Salvia miltiorrhiza radix, has been reported to have antioxidant effects. We examined the effects of LAB on the prevention of diabetic retinopathy in Otsuka Long-Evans Tokushima Fatty (OLETF) rats, an animal model of type 2 diabetes.Methods and FindingsLAB (10 or 20 mg/kg) or normal saline were given orally once daily to 24-week-old male OLETF rats for 52 weeks. At the end of treatment, fundoscopic findings, vascular endothelial growth factor (VEGF) expression in the eyeball, VEGF levels in the ocular fluid, and any structural abnormalities in the retina were assessed. Glucose metabolism, serum levels of high-sensitivity C-reactive protein (hsCRP), monocyte chemotactic protein-1 (MCP1), and tumor necrosis factor-alpha (TNFα) and urinary 8-hydroxy-2′-deoxyguanosine (8-OHdG) levels were also measured. Treatment with LAB prevented vascular leakage and basement membrane thickening in retinal capillaries in a dose-dependent manner. Insulin resistance and glucose intolerance were significantly improved by LAB treatment. The levels of serum hsCRP, MCP1, TNFα, and urinary 8-OHdG were lower in the LAB-treated OLETF rats than in the controls.ConclusionsTreatment with LAB had a preventive effect on the development of diabetic retinopathy in this animal model, probably because of its antioxidative effects and anti-inflammatory effects.

show abstract

Oxidative Stress in Preretinopathic Diabetes Subjects and Antioxidants

Abstract: Results of this preliminary study suggest that an oral treatment with AOs in PRD subjects may have a protective effect on retinal cells, as detected by ERG analysis, through the strengthening of the plasma AO barrier.

Cited by 45 publications

References 29 publications

Oxidative stress, mitochondrial damage and diabetic retinopathy

Oxidative stress, mitochondrial damage and diabetic retinopathy

Efficacy of α-lipoic acid in diabetic neuropathy

The Effect of Lithospermic Acid, an Antioxidant, on Development of Diabetic Retinopathy in Spontaneously Obese Diabetic Rats

Contact Info

Product

Resources

About