Oxidative stress in rat brain but not in liver following oral administration of a low dose of nanoparticulate silver

Skalska, Joanna; Dąbrowska–Bouta, Beata; Strużyńska, Lidia

doi:10.1016/j.fct.2016.09.026

Cited by 61 publications

(46 citation statements)

References 58 publications

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“…1c), which is mostly in the form of GSH, supports this thesis. This interpretation of the data is supported also by our previous results showing a lower reduced-to-oxidized glutathione ratio in brains of AgNP-treated rats (Skalska et al 2016). This deficiency of reduced glutathione (GSH) presumably emerges from direct interactions between silver and –SH groups since it is known that silver generally has a high affinity for –SH groups (Bragg and Rainnie 1974) .…”

Section: Discussionsupporting

confidence: 89%

“…Our previous results revealed that AgNPs induce alterations in the expression of myelin-specific proteins CNP, MAG, and MOG which may cause the observed ultrastructural changes in myelin sheaths (Dąbrowska-Bouta et al 2016). Moreover, we also observed induction of oxidative stress in the homogenates of the whole brain of rats subjected to a low dose of particulate silver (Skalska et al 2016). Based on these data, we hypothesized that myelin in the CNS, whose membranes are composed of lipids rich in unsaturated fatty acids, may be a target of AgNP-induced oxidative stress.…”

Section: Introductionmentioning

confidence: 60%

“…AgNPs were reported to alter the expression of oxidative stress-related genes (Rahman et al 2009; Krawczyńska et al 2015), as well as biochemical parameters (Skalska et al 2016). …”

Section: Discussionmentioning

confidence: 99%

“…A number of in vitro studies on the toxicity of AgNPs in various cellular systems have shown that AgNPs influence the function of mitochondria, perturb cellular respiration, and increase free radical production, consequently leading to oxidative stress and cell death (AshaRani et al 2009; Foldbjerg et al 2009; Piao et al 2011; Ziemińska et al 2014). In addition, animal experimental models have also linked oxidative stress to AgNP-induced cytotoxicity (Strużyński et al 2013; Wu and Zhou 2013; Skalska et al 2016). In AgNP-exposed rodents, up-regulation of oxidative stress-related genes has been demonstrated (Rahman et al 2009).…”

Section: Introductionmentioning

confidence: 99%

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Prolonged Exposure to Silver Nanoparticles Results in Oxidative Stress in Cerebral Myelin

et al. 2018

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Currently, silver nanoparticles (AgNPs) are frequently used in a wide range of medical and consumer products. Substantial usage of AgNPs is considered to create substantive risks to both the environment and the human health. Since there is increasing evidence that the main mechanism of toxicity of AgNPs relates to oxidative stress, in the current study we investigate oxidative stress-related biochemical parameters in myelin isolated from adult rat brain subjected to a low dose of AgNPs. Animals were exposed for 2 weeks to 0.2 mg/kg b.w. of small (10 nm) AgNPs stabilized in citrate buffer or silver citrate established as a control to compare the effects of particulate and ionic forms of silver. We observe enhanced peroxidation of lipids and decreased concentrations of protein and non-protein –SH groups in myelin membranes. Simultaneously, expression of superoxide dismutase, a free radical scavenger, is increased whereas the process of protein glutathionylation, being a cellular protective mechanism against irreversible oxidation, is found to be inefficient. Results indicate that oxidative stress-induced alterations in myelin membranes may be the cause of ultrastructural disturbances in myelin sheaths.

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Section: Discussionsupporting

confidence: 89%

Section: Introductionmentioning

confidence: 60%

“…AgNPs were reported to alter the expression of oxidative stress-related genes (Rahman et al 2009; Krawczyńska et al 2015), as well as biochemical parameters (Skalska et al 2016). …”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Prolonged Exposure to Silver Nanoparticles Results in Oxidative Stress in Cerebral Myelin

et al. 2018

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“…However, it is not known whether Ag NPs provoke such a disease. It was shown that 10 nm of citratestabilized Ag NPs accumulation leads to oxidative stress in brain [89]. This suggests that Ag NPs may pass through the blood-brain barrier (BBB).…”

Section: In Vivo Toxicological Information and Experiments About Silvmentioning

confidence: 99%

Assessment of Nano-toxicity and Safety Profiles of Silver Nanoparticles

Budama‐Kilinc¹,

Çakır-Koç²,

Zorlu³

et al. 2018

Silver Nanoparticles - Fabrication, Characterization and Applications

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Nanotoxicology, which is related with toxic potentials of nanoparticles (NPs) and their adverse effects on living organisms and environment, is a sub-branch of toxicology discipline. Nano-toxicity of NPs depends on their doses, unique chemical, and physical properties. Nowadays, silver (Ag) NPs are used in many consumer and scientific applications such as antimicrobial and pharmaceutical applications, water purification systems, textile industry, and food packaging processes. However, the information that about their nano-toxic potentials is still not complete, and it is considered that several parameters of Ag NPs such as size, shape, surface, and stability affect the toxic potential in different ways. Nano-toxic potentials of Ag NPs were mentioned as in vivo, in vitro, and in silico the studies. In this chapter, it was evaluated the common unique properties of NPs are related with nanotoxicology such as size, surface area and modifications, shape, agglomeration status, and dose. : in vivo, in vitro, in silico, nanoparticles, nano-toxicity, silver within organism, and the mechanisms of the actions. At the same time, this concept involves the isolation of the poisons, the analysis of toxic materials as quantitative and qualitative besides that risk analyses, optimization processes, and treatments of poisons [1]. Keywords

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Advanced Nanomaterials for Cancer Therapy: Gold, Silver, and Iron Oxide Nanoparticles in Oncological Applications

Singh,

Pandit,

Balusamy

et al. 2024

Adv Healthcare Materials

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Cancer remains one of the most challenging health issues globally, demanding innovative therapeutic approaches for effective treatment. Nanoparticles, particularly those composed of gold, silver, and iron oxide, have emerged as promising candidates for changing cancer therapy. This comprehensive review demonstrates the landscape of nanoparticle‐based oncological interventions, focusing on the remarkable advancements and therapeutic potentials of gold, silver, and iron oxide nanoparticles. Gold nanoparticles have garnered significant attention for their exceptional biocompatibility, tunable surface chemistry, and distinctive optical properties, rendering them ideal candidates for various cancer diagnostic and therapeutic strategies. Silver nanoparticles, renowned for their antimicrobial properties, exhibit remarkable potential in cancer therapy through multiple mechanisms, including apoptosis induction, angiogenesis inhibition, and drug delivery enhancement. With their magnetic properties and biocompatibility, iron oxide nanoparticles offer unique cancer diagnosis and targeted therapy opportunities. This review critically examines the recent advancements in the synthesis, functionalization, and biomedical applications of these nanoparticles in cancer therapy. Moreover, the challenges are discussed, including toxicity concerns, immunogenicity, and translational barriers, and ongoing efforts to overcome these hurdles are highlighted. Finally, insights into the future directions of nanoparticle‐based cancer therapy and regulatory considerations, are provided aiming to accelerate the translation of these promising technologies from bench to bedside.

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Oxidative stress in rat brain but not in liver following oral administration of a low dose of nanoparticulate silver

Cited by 61 publications

References 58 publications

Prolonged Exposure to Silver Nanoparticles Results in Oxidative Stress in Cerebral Myelin

Prolonged Exposure to Silver Nanoparticles Results in Oxidative Stress in Cerebral Myelin

Assessment of Nano-toxicity and Safety Profiles of Silver Nanoparticles

Advanced Nanomaterials for Cancer Therapy: Gold, Silver, and Iron Oxide Nanoparticles in Oncological Applications

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