Oxidative stress in the erythrocytes of cattle intoxicated with<i>Senecio</i>sp

Bondan, Carlos; Soares, Júlio César Mendes; Cecim, Marcelo; Lopes, Sônia Terezinha dos Anjos; Graça, Dominguita Lühers; Rocha, Ricardo Xavier da

doi:10.1111/j.1939-165x.2005.tb00060.x

Cited by 15 publications

(10 citation statements)

References 24 publications

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“…Sharma et al (1981) reported increased erythrocyte osmotic fragility in calves poisoned by lantana. Erythrocyte osmotic fragility increased due to lipid peroxidation and oxidative stress in cattle intoxicated with Senico sp (Bondan et al, 2005). Gossypol, a yellow polyphenolic compound, from whole cottonseed or cotton seed meal had been reported to increase the osmotic fragility of lactating cows (Mena et al, 2004), growing heifers (Colin-Negrete et al, 1996), cattle (Wyse et al, 1991), sheep and goats (Menges 1991;Matondi et al, 2007).…”

Section: Extracts Of Leaves Plants and Herbsmentioning

confidence: 99%

A review of the factors that influence erythrocyte osmotic fragility

Igbokwe¹

2019

Sokoto J. Vet. Sc.

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Erythrocyte osmotic fragility is a laboratory test which evaluates the stability of the erythrocyte membrane to osmotic stress. The aim of this review is to highlight research findings on the intrinsic and extrinsic factors that influence erythrocyte osmotic fragility. The extrinsic factors include the type, ionic strength and pH of incubation media, type of anticoagulant and storage time of the blood, ambient temperature, drugs, medicinal plant extracts, xenobiotics, chemical agents; whereas intrinsic factors are age, sex, breed, species, pregnancy, lactation and genetic factors. Membrane composition, ion transports, aquaporin action, lipid peroxidation, and eryptosis of erythrocytes are involved in the variability of osmotic fragility. Increased osmotic fragility and improved osmotic stability of erythrocytes are pathophysiological phenomena that require appropriate interpretation in research or clinical investigation and the understanding of the factors affecting osmotic fragility will aid in the laboratory assessment of conditions related to erythrocytes where erythrocyte osmotic fragility test is used.

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Section: Extracts Of Leaves Plants and Herbsmentioning

confidence: 99%

A review of the factors that influence erythrocyte osmotic fragility

Igbokwe¹

2019

Sokoto J. Vet. Sc.

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“…Pyrrolizidine alkaloids (PA), eremophilanolides and cacalolides are characteristic compounds isolated from Senecio species (13). Although the toxic effects exhibited by these plants have been largely attributed to their content of PA (14) the development of oxidative stress and the consequent generation of reactive oxygen species (ROS) and ROS-mediated cellular damage (15,16), likely also contribute to toxicity.…”

Section: Introductionmentioning

confidence: 99%

The selective cytotoxicity elicited by phytochemical extract from Senecio graveolens (Asteraceae) on breast cancer cells is enhanced by hypoxia

Echiburú-Chau¹,

Alfaro-Lira

Brown

et al. 2014

International Journal of Oncology

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Breast cancer is the second cause of cancer‑related deaths in woman and the incidence of the disease has increased worldwide, in part due to improvements in early detection. Several drugs with anticancer effects have been extracted from plants in the last 20 years, many of which are particularly effective against breast cancer cells. In particular, we have become interested in the ethanolic extract from Senecio graveolens (synonym of S. nutans), a plant commonly called Chachacoma, in an effort to isolate compounds that could demonstrate cytotoxic effects on breast cancer cells. Senecio (Asteraceae) is the largest gender in Chile comprising approximatly 200 species. These herbs inhabit areas over 3,500 meters above the sea level in the Andes Mountains. S. graveolens is commonly used by local communities for its medicinal properties, particularly its capacity to ameliorate high-altitude-associated sickness. The cytotoxic effect of the alcoholic extract from S. graveolens, as well as its most abundant compound 4-hydroxy-3-(3-methyl-2-butenyl)acetophenone, were tested in the breast cancer cell lines ZR-75-1, MCF-7 and MDA-MB‑231, and non-tumorigenic MCF-10F cells. We show that the phytochemical extract was able to induce cytotoxicity in cancer cells but not in MCF-10F. Importantly, this effect was enhanced under hypoxic conditions. However, 4-hydroxy-3-(3-methyl-2-butenyl)acetophenone, the main compound, did not by itself show an effective anticarcinogenic activity in comparison to the whole extract. Interestingly, the cytotoxic effect of the phytochemical extract was dependent on the basal MnSOD protein expression. Thus, cytotoxicity was increased when MnSOD levels were low, but resistance was evident when protein levels were high. Additionally, the crude extract seems to trigger cell death by a variety of processes, including autophagy, apoptosis and necrosis, in MCF-7 cells. In summary, S. graveolens extract possess anticancer activity displaying a specific cytotoxic effect on cancer cells, thus serving as a potential source of phytochemical compounds for cancer treatment.

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“…Oxidative stress has been evaluated in people in many different diseases including asthma, active and passive smoking, heart failure, renal failure, cancer, COPD, pulmonary hypertension, diabetes mellitus, ischemia and reperfusion injury, periodontal disease, blunt trauma, pneumonia, and ARDS . In large animals, changes in various biomarkers indicative of oxidative stress has been documented in a wide variety of conditions including recurrent airway obstruction in horses and various inflammatory diseases in cows and horses …”

Section: Inflammatory Respiratory Diseasementioning

confidence: 99%

“…306 In large animals, changes in various biomarkers indicative of oxidative stress has been documented in a wide variety of conditions including recurrent airway obstruction in horses and various inflammatory diseases in cows and horses. [307][308][309][310][311][312][313][314][315][316][317][318][319][320] There are several markers of oxidative stress that have been evaluated in dogs and cats in many different disease states, some of which are inflammatory in nature. [321][322][323][324][325][326][327][328][329][330][331][332][333][334][335][336][337] These include antioxidants such as vitamins A, C, and E; glutathione; cysteine; oxygen radical absorbance capacity; lipid peroxidation via malondialdehyde; oxidative damage to DNA; and elemental concentration of copper, selenium, zinc, magnesium, and iron.…”

Section: Oxidative Stressmentioning

confidence: 99%