Oxidative stress in the pathogenesis of type 1 diabetes: the role of adipocyte xanthine oxidase

Иванов, В. В.; Шахристова, Е. В.; Степовая, Е. А.; Литвяков, Н. В.; Перекуча, Н. А.; Носарева, О. Л.; Фёдорова, Т. С.; Новицкий, В. В.

doi:10.20538/1682-0363-2017-4-134-143

Cited by 5 publications

(3 citation statements)

References 15 publications

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“…These results highlighted that oxidative stress, as a key factor, contributes to the progression of UC. Studies have also shown that allopurinol can inhibit XDH mRNA transcription in the adipocytes of alloxan-induced diabetes rats [32]. Our results showed that DPI and allopurinol could inhibit the XOR upregulation in colonic mucosa and that allopurinol can also inhibit CoCl 2 -induced XOR upregulation in colon epithelial cells.…”

Section: Discussionsupporting

confidence: 70%

Hypoxia-Mediated Upregulation of Xanthine Oxidoreductase Causes DNA Damage of Colonic Epithelial Cells in Colitis

Li,

Wang

et al. 2024

Inflammation

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Xanthine oxidoreductase (XOR) is the primary source of hydrogen peroxide and superoxide anions in the intestinal mucosa. However, its speci c contribution to the colonic disease progression remains unclear. In this study, we investigated the role of XOR in ulcerative colitis (UC) and attempted to identify the underlying mechanisms. We used the dextran sulfate sodium (DSS)-induced mouse model to mimic UC and found that the XOR inhibitors (allopurinol and diphenyleneiodonium sulfate (DPI) signi cantly alleviated UC in mice. Also, cobalt chloride (CoCl 2 ) and 1% O 2 treatment increases the expression of XOR and caused DNA oxidative damage in colonic epithelial cells. Furthermore, we found that XOR accumulated in the nucleus may directly cause DNA oxidative damage and regulates HIF1α protein levels. In addition, allopurinol effectively protected colon epithelial cells from CoCl 2 -induced DNA damage. Altogether, our data provide new evidence that XOR could induce DNA damage under hypoxic conditions indicating a signi cant role of XOR in the initiation and early development of colitis-associated colorectal cancer (CAC).

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Section: Discussionsupporting

confidence: 70%

Hypoxia-Mediated Upregulation of Xanthine Oxidoreductase Causes DNA Damage of Colonic Epithelial Cells in Colitis

Li,

Wang

et al. 2024

Inflammation

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“…Численні дослідження, в тому числі з морфології змін судинної стінки, а саме базальної мембрани при ЦД1, вказують на її потовщення у судинах мікроциркуляторного русла скелетних м'язів, предиктором чого є ступінь і тривалість гіперглікемії [3]. Згідно з сучасними уявленнями про механізми виникнення цукрового діабету як 1-го, так і 2-го типу та розвиток їх ускладнень, важливу роль відіграє окиснювальний стрес [4]. У науковій літературі зберігається інтерес до вивчення ролі гомоцистеїну та нітротирозину як маркерів окиснювального стресу в патогенезі цукрового діабету [5,6].…”

Section: окиснювальний стрес як фактор ризику розвитку діабетичної міопатії у дітейunclassified

Окислительный Стресс Как Фактор Риска Развития Диабетической Миопатии У Детей

Pashkovа¹,

Chudova²

2021

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Background. The purpose was to determine the pathogenetic role of oxidative stress in the development of diabetic myopathy in children with diabetes mellitus. Materials and methods. The study included 60 children with type 1 diabetes mellitus (DM1), aged 11 to 17 years. Group 1 included 20 patients with a duration of disease less than 1 year. Group 2 consisted of 20 patients with a duration of diabetes from 1 to 5 years. Group 3 was formed of 20 kids with the duration of diabetes over 5 years. The control group consisted of 20 apparently healthy children. All children underwent the skeletal muscle index determination, ultrasound examination of skeletal muscles, and determination of the level of creatine phosphokinase, homocysteine, and nitrotyrosine in the blood serum. Results. According to the conducted ultrasound diagnostics, the DM1 children were found to present a decrease in the mass of skeletal muscles due to a reduced muscle thickness in the dynamics of the disease. It was proved that hyperglycemia in children with DM1 resulted in the significant oxidative stress confirmed by an increase in the blood serum content of homocysteine and nitrotyrosine, and damage to skeletal muscles, which was confirmed by high blood serum levels of creatine phosphokinase, started from 1 year of illness. Significant changes were found in group 3 of children, where high values of homocysteine and nitrotyrosine were determined in comparison with both the control and group 1 of the study (p < 0.05). An inverse correlation was found between the levels of homocysteine, nitrotyrosine, and the skeletal muscle index, respectively (r = –0.39 (p < 0.05); r = –0.35 (p < 0.05)), and the dependence of these indicators on the state of glycemic control. Conclusions. There is a progressively increased activity of creatine phosphokinase from 1 year of DM1, which indicated early damage to the muscle tissue in children with type 1 diabetes mellitus. One of the causes of skeletal muscle damage and the formation of diabetic myopathy in diabetic children is oxidative stress, which increased with poor glycemic control.

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“…Discussion. Modern ideas about the pathogenetic mechanisms of complications of diabetes mellitus, including diabetic myopathy, indicate the leading role of oxidative stress in the pathogenesis of their development [6,7]. The increased activity of oxidative processes leads to the progression of pathological changes in the microvascular blood flow and the gradual depletion of the capillary network in skeletal muscles.…”

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confidence: 99%

Risk Factors for Developing Diabetic Myopathy in Children With Type 1 Diabetes Mellitus

Chudova

Pashkovа

2021

RS Global - World Science

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Aim of study: to determine the pathogenetic factors that have an impact on the development of diabetic myopathy in children with DM1, to investigate the structure of the factors. The observation group included 136 children 14.3 ± 0.3 years old who have been suffering from DM1 for 1 to 10 years. Diagnosed diabetic myopathy in 45 (33.1%) patients (19 (24.4%) boys and 25 (44.8%) girls). By factor analysis, 5 factors were identified that are of leading importance in the pathogenesis of the development of diabetic myopathy in children with DM1. These factors accounted for 73.33% of the total dispersion. The first rank place was represented by the group factor (nitrotyrosine and homocysteine), which accounted for 19.54% of the total dispersion; interpreted as a factor of "oxidative stress". The second rank place was represented by the content of triglyceride in the blood serum and the level of the triglyceride-glucose complex, which amounted to 16.69% of the total dispersion; interpreted as "insulin resistance factor". The third rank place was interpreted as "the state of peripheral blood supply", which accounted for 13.93% of the total variance, and included the indicators of the ankle-brachial index before and after exercise stress. The fourth rank place was interpreted as an "anamnestic factor", which accounted for 12.04% of the total dispersion, and included three risk factors: age, sex of the patient, and duration of DM1. The fifth factor ("inflammation factor") included the indicators of glycosylated hemoglobin and interleukin-6, and demonstrates the development of chronic low-level inflammation against the background of hyperglycemia. Thus, using factor analysis, we determined that oxidative stress, insulin resistance, impaired peripheral circulation, duration of diabetes mellitus, female sex, chronic hyperglycemia, increased activity of proinflammatory cytokines had a priority effect on the pathogenesis of diabetic myopathy. We have formed a factorial model that will optimize the diagnosis of diabetic myopathy, improve approaches to its therapy and prevention, identifying among children with DM1 the risk group for the development and progression of this complication.

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Oxidative stress in the pathogenesis of type 1 diabetes: the role of adipocyte xanthine oxidase

Cited by 5 publications

References 15 publications

Hypoxia-Mediated Upregulation of Xanthine Oxidoreductase Causes DNA Damage of Colonic Epithelial Cells in Colitis

Hypoxia-Mediated Upregulation of Xanthine Oxidoreductase Causes DNA Damage of Colonic Epithelial Cells in Colitis

Окислительный Стресс Как Фактор Риска Развития Диабетической Миопатии У Детей

Risk Factors for Developing Diabetic Myopathy in Children With Type 1 Diabetes Mellitus

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