Oxidative stress in the retina: Implications for retinopathy of prematurity

Couroucli, Xanthi I.

doi:10.1016/j.cotox.2017.11.008

Cited by 8 publications

(5 citation statements)

References 72 publications

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“…Moreover, always in adults, the increase of oxidized proteins has been associated with multiple diseases, like cancer, heart failure, pre-eclampsia, ARDS, Parkinson, Alzheimer, and sepsis (Floor and Wetzel, 1998; Lenz et al, 1999; Winterbourn et al, 2000; Butterfield et al, 2001; Zusterzeel et al, 2001; Abu-Zidan et al, 2002; Castegna et al, 2002). In the neonatal period, the oxidation of proteins plays a key role in some diseases such as intraventricular hemorrhage, retinopathy of prematurity, bronchopulmonary dysplasia, NEC (Gladstone and Levine, 1994; Ramsay et al, 2001; Perrone et al, 2009, 2010, 2014, 2018; Couroucli, 2017).…”

Section: Redox Biology and Oxidative Stressmentioning

confidence: 99%

Oxidative Stress and Neonatal Respiratory Extracorporeal Membrane Oxygenation

et al. 2018

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Oxidative stress is a frequent condition in critically ill patients, especially if exposed to extracorporeal circulation, and it is associated with worse outcomes and increased mortality. The inflammation triggered by the contact of blood with a non-endogenous surface, the use of high volumes of packed red blood cells and platelets transfusion, the risk of hyperoxia and the impairment of antioxidation systems contribute to the increase of reactive oxygen species and the imbalance of the redox system. This is responsible for the increased production of superoxide anion, hydrogen peroxide, hydroxyl radicals, and peroxynitrite resulting in increased lipid peroxidation, protein oxidation, and DNA damage. The understanding of the pathophysiologic mechanisms leading to redox imbalance would pave the way for the future development of preventive approaches. This review provides an overview of the clinical impact of the oxidative stress during neonatal extracorporeal support and concludes with a brief perspective on the current antioxidant strategies, with the aim to focus on the potential oxidative stress-mediated cell damage that has been implicated in both short and long-term outcomes.

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Section: Redox Biology and Oxidative Stressmentioning

confidence: 99%

Oxidative Stress and Neonatal Respiratory Extracorporeal Membrane Oxygenation

et al. 2018

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“…In phase 1, from birth to approximately 30 weeks postmenstrual age, retinal vascularization is restricted by hyperoxia (due to supplemental oxygen therapy), a lack of nutrition, and growth hormones from the mother-child interface. Blood vessel growth decreases as the retina ages and metabolic demands increase, leading to hypoxia [7][8][9]. When the infant is shifted from respiratory support to room air, the hypoxic retina is brought on by phase 2 oxygen-regulated molecules such as VEGF and erythropoietin (EPO) that work to stimulate neovascularization of the retina.…”

Section: Figurementioning

confidence: 99%

“…This results in the stop of retinal vessel formation and the depletion of certain existing retinal vessels. In better-developed babies, exposure to high oxygen concentrations lowers preexisting vasculature that is not seen with a controlled oxygen supply, which largely prevents vessel creation, claim a few studies [8].…”

Section: Phase 1 (Vasoconstrictive Phase)mentioning

confidence: 99%

A Narrative Review on Managing Retinopathy of Prematurity: Insights Into Pathogenesis, Screening, and Treatment Strategies

Bishnoi,

Prasad,

Upadhyay

et al. 2024

Cureus

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Retinopathy of prematurity (ROP) is a rare proliferative ocular condition that can happen in premature babies (born preterm <36 weeks) or who weigh <1.5 kg at birth (low birth weight babies). ROP is a major cause of childhood blindness. It is a premature disease since retina vascularization is completed only by 40 weeks of life. The survivability for preterm infants has increased owing to recent improvements in neonatal care during the past decade. As a result, the prevalence of ROP has risen concurrently. The abnormal development of blood vessels in the retina is the cause of this illness.It occurs in two phases, phases 1 and 2. Most preterm infants weighing <1.5 kg need supplemental oxygen for respiratory support at birth. This leads to the initiation of phase 1 (vasoconstrictive phase). Phase 1 is characterized by loss of maternal-fetal connection and hyperoxia due to supplemental oxygen therapy. Oxygen's vasoconstrictive and obliterative action is primarily observed in developing retinal vessels. The inhibition of vascular endothelial growth factor follows from this. Phase 2 (vasoproliferative phase) shows the dilatation and tortuosity of the bigger existing vessels together with neovascularization and proliferation of new vessels into the vitreous when the baby is shifted from respiratory support to room air. Now, the retina gets hypoxic, where the retina becomes more metabolically active but is yet minimally vascularized, leading to VEGF-induced vasoproliferation, which might result in retinal detachment.Patients with ROP face the danger of loss of vision. If correct and quick treatment is not provided, they might land into permanent blindness. Yet, ROP remains one of the most preventable causes of childhood blindness worldwide. Blindness caused by ROP can only be avoided if screening programs are readily available, pertinent, and appropriate. The initial stage in the therapy of ROP is the screening of premature neonates. Timely screening and management for ROP is important to avoid this irreversible loss of vision. The treatment is based on the severity of the disease. Management may include pharmacological interventions like intravitreal and anti-vascular endothelial growth factor and nonpharmacological interventions like laser surgery, vitrectomy, and scleral buckling.We conducted a thorough literature search of studies on pathogenesis, risk factors, classification, and various treatment options for retinopathy of prematurity in infants, using a mixture of pertinent keywords. Only those studies published in peer-reviewed journals between 2010 and 2023 and written in English were included. Duplicate studies, unavailable in full-text for free, or studies unrelated to our subject matter were excluded. After thoroughly evaluating the selected studies, the results were synthesized and presented narratively. This article sheds light on the pathogenesis of ROP, particularly its relation to oxygen use, screening, and potential therapeutic management of ROP. Today advances in screening techniques have improved th...

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“…It starts after preterm birth when supplemental oxygen, required during resuscitation/stabilization in the delivery room, causes cessation of normal retinal vascularization. The enhanced production of ROS, due to supplemental oxygen, determines structural and functional changes in several retinal molecules leading to the arrest of neurovascular development and the obliteration of existing vascular beds [ 64 ].…”

Section: Free Radical Disease In Newbornmentioning

confidence: 99%

Oxygen for the Newborn: Friend or Foe?

et al. 2023

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Oxygen supplementation is widely used in neonatal care, however, it can also cause toxic effects if not used properly. Therefore, it appears crucial to find a balance in oxygen administration to avoid damage as a consequence of its insufficient or excessive use. Oxygen toxicity is mainly due to the production of oxygen radicals, molecules normally produced in humans and involved in a myriad of physiological reactions. In the neonatal period, an imbalance between oxidants and antioxidant defenses, the so-called oxidative stress, might occur, causing severe pathological consequences. In this review, we focus on the mechanisms of the production of oxygen radicals and their physiological functions in determining a set of diseases grouped together as “free radical diseases in the neonate”. In addition, we describe the evolution of the oxygenation target recommendations during neonatal resuscitation and post-stabilization phases with the aim to define the best oxygen administration according to the newest evidence.

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Oxidative stress in the retina: Implications for retinopathy of prematurity

Cited by 8 publications

References 72 publications

Oxidative Stress and Neonatal Respiratory Extracorporeal Membrane Oxygenation

Oxidative Stress and Neonatal Respiratory Extracorporeal Membrane Oxygenation

A Narrative Review on Managing Retinopathy of Prematurity: Insights Into Pathogenesis, Screening, and Treatment Strategies

Oxygen for the Newborn: Friend or Foe?

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