Oxidative stress in thyroid dysfunction

Abstract

Thyroidal dysfunction is a risk factor for the development of many metabolic disorders and pathologies. In this work we evaluated the status of the oxidative stress in hypo- and hyperthyroidism, as a sign for developing associated diseases. A total of 44 participants have been recruited and distributed into three groups: Euthyroidism (6), Hypothyroidism (29) and hyperthyroidism (9). Their hematological and biochemical parameters were diagnosed. Free thyroxin 4 (FT4) and thyroid stimulating hormone (TSH) were determined using Elisa kits. Malondialdehyde (MDA), glutathione peroxidase (GPx), superoxide dismutase (SOD) and glutathione (GSH) were measured in plasma samples by spectrophotometric methods. Our results showed an increase in lipid peroxidation in both hypo- and hyperthyroidism (1.14 ±0.631 µmol. L-1 and 0.904 ±0.179 µmol. L-1 , respectively) in comparison to normal cases (0.821 ±0.173 µmol.L-1 ). Our findings highlight the misbalance of the oxidative stress occurrence in hypo- and hyper-thyroidism due to the subsequent metabolic rate disturbances.

Changes in Lipid and Protein Peroxidation in Blood Serum and Respiratory Lungs Homogenate in Experimental Iodine Deficiency, Insulin Resistance and Their Combination

“…Under conditions of excessive thyroid function, free radical processes are sharply intensifi ed, which refl ects the growth of LPO and OMP products [4,5,6]. The main points of application of thyroid hormones are the intracellular receptors of the mitochondria and the nucleus.…”

“…It is known about a decrease in the level of reactive oxygen sorts due to the inhibition of metabolic processes in the body in conditions of hypothyroidism. In hypothyroid animals, the activity of antioxidant enzymes, in particular those belonging to the fi rst line, decreases (superoxide desmutases -SOD, catalases and glutathione peroxidase -GP) [4,5]. At the same time, oxygen tissues starvation and activation of LPO are reactions that characterize the course of most pathological processes, especially those that have a chronic course and are accompanied by the development of destructive changes in tissues and organs [4,9].…”