Oxidative Stress in Tunisian Patients With Acute Lymphoblastic Leukemia and Its Involvement in Leukemic Relapse

Mahmoud, Lobna Ben; Mdhaffar, M.; Ghozzi, H.; Ammar, Mariam; Hakim, Ahmed; Atheymen, Rim; Sahnoun, Zouheir; Elloumi, Moez; Zeghal, Khaled Mounir

doi:10.1097/mph.0000000000000793

Cited by 15 publications

(19 citation statements)

References 31 publications

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“…It is well known that overproduction of ROS such as superoxide radicals (O 2 •− ), hydrogen peroxide (H 2 O 2 ), and the highly reactive hydroxyl radicals (OH • ) leads to the oxidative damage of lipids, proteins, and DNA . If not repaired DNA damage may bring mutagenesis and cause the onset or the development of different types of cancers, high ROS level was particularly incriminated in the resistance to BCR/ABL kinase inhibitors established in experimental cell lines. Our study was conducted to comprehend the mechanisms of resistance to IM order to find therapeutic solutions that may help prevent a relapse from this drug in CML.…”

Section: Discussionmentioning

confidence: 99%

Relationship of oxidative stress in the resistance to imatinib in Tunisian patients with chronic myeloid leukemia: A retrospective study

Ammar

Mahmoud

Medhaffar

et al. 2019

Clinical Laboratory Analysis

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Background This work aimed to evaluate oxidative stress in chronic myeloid leukemia (CML) patients treated with tunisian (IM) vs controls and in CML patients with resistance to IM vs patients without resistance to IM. Methods The study included 40 CML patients and 34 controls. Of 40 patients with CML, 26 patients were developed in resistance to IM. The oxidant/antioxidant markers were evaluated by spectrophotometric methods for all used samples. Results For CML patients, increased malondialdehyde (MDA) and advanced oxidation protein products (AOPP) levels were found compared to controls (P < .001; P = .01). Higher catalase (CAT) activity (P = .048) and lower superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities, reduced Glutathione (GSH) and vitamin C levels were found in CML patients (P < .001). The comparison between the resistant vs no‐resistant CML patients revealed higher MDA level (P = .02) and CAT and SOD activities in IM‐resistant patients (P = .04, P = .03). GPx activity was reduced (P = .04). Furthermore, increased mean ratio of MDA/GSH, MDA/GPx, and SOD/(GPx + CAT) was found in IM‐resistant patients as compared with no‐resistant (P = .01, P = .01, P = .035). The mean ratio of GPx/GSH in the IM‐resistant CML patients was lower than in IM no‐resistant one (P = .039). For IM‐resistant patients, we found negative correlation between MDA level and the ratio SOD/(CAT + GPx) (r = −0.46, P = .002); and positive correlation between SOD and (CAT + GPx) activities (r = 0.38, P = .06) and between GSH level and GPx activity (r = 0.53, P = .01). Conclusions Our results have shown a highly disturbed oxidative profile in IM‐resistant CML patients as compared to no‐resistant. The H2O2 has a key role in the resistance to IM treatment.

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Section: Discussionmentioning

confidence: 99%

Relationship of oxidative stress in the resistance to imatinib in Tunisian patients with chronic myeloid leukemia: A retrospective study

Ammar

Mahmoud

Medhaffar

et al. 2019

Clinical Laboratory Analysis

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“…During this study total inhibitor capability (TAC) cut considerably all told growth tissue during a correlational statistics with MDA levels which can be explained with the ensuing result of the SFN conjugation with the intracellular thiols of the tumor cells, like GSH, leading to a decrease within the pool of cellular-SH teams, which is able to doubtless render cells additional at risk of aerophilous stress [47], Is in agreement with Sarban et al World Health Organization studied the inhibitor arms in patients with atrophic arthritis, they reported associate degree multiplied MDA concentration that is that the most potent marker of aerophilous stress and cut levels of TAC and inhibitor enzymes [48] [49].…”

Section: Ferreira First State Oliveira Et Al (2014) Additionallymentioning

confidence: 96%

Role of Sulforaphane on Histone Deacetylase Activity in Solid Ehrlich Carcinoma

El-Keey¹,

Ibrahim²,

El-Ghonamy³

et al. 2020

JBM

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Histone acylation is one in every of the posttranslational modification that incorporates a role within the regulation of sequence expression. This study was aimed to ameliorate neoplasm cell model Solid Ehrlich malignant neoplastic disease with sulforaphane extracted from cabbage alone and together with immune suppressant drug (MTX) by study the activity of simple protein deacetylase accelerator (HDAC). In this study, sulforaphane was extracted from cabbage leaves and evaluated victimization GC-MS and ultraviolet illumination spectrophotometry. 60 white male rats were divided into six equal groups. Group I: management ordinarily. The remaining mice were subjected to Ehrlich neoplasm cells. Group II: Tumor-bearing group. Group III: immune suppressant drug "MTX" treated group. Group IV, V treated with SFN before and when Paul Ehrlich cells implantation group VI (Methotrexate and sulforaphane-treated group). This result showed that sulforaphane was extracted from cabbage (Brassica oleracea) in concentration of 833 µg/g leave. HDAC was attenuated when treatment with sulforaphane after treatment with methotrexate or sulforaphane alone. The desoxyribonucleic acid injury was attenuated in neoplasm tissue of tumor-bearing mice when treatment with immune suppressant drug and hyperbolic considerably in tumor tissue of tumor-bearing mice treated with sulforaphane before and after carcinogenesis and together with methotrexate treatment after carcinogenesis.

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“…Battisti et al evaluated the oxidative status and antioxidant defense of patients with ALL and found that CAT and SOD activities in the whole blood of patients with ALL were lower by different levels than those in the normal control group and that SOD activity was lowest in newly diagnosed patients [ 105 ]. However, Ben Mahmoud et al found that the plasmatic activities of CAT and SOD and the plasma levels of reduced GSH were elevated in patients with ALL and that SOD activity and GSH levels were substantially correlated with ALL relapse [ 108 ]. Nishiura et al found that serum levels of Mn-SOD in patients with ALL were substantially higher than those in normal controls, but as the disease subsided, serum levels of Mn-SOD decreased [ 109 ].…”

Section: Redox Regulation In Leukemiamentioning

confidence: 99%

Redox Control in Acute Lymphoblastic Leukemia: From Physiology to Pathology and Therapeutic Opportunities

Chen

Zhao

2021

Cells

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Acute lymphoblastic leukemia (ALL) is a hematological malignancy originating from B- or T-lymphoid progenitor cells. Recent studies have shown that redox dysregulation caused by overproduction of reactive oxygen species (ROS) has an important role in the development and progression of leukemia. The application of pro-oxidant therapy, which targets redox dysregulation, has achieved satisfactory results in alleviating the conditions of and improving the survival rate for patients with ALL. However, drug resistance and side effects are two major challenges that must be addressed in pro-oxidant therapy. Oxidative stress can activate a variety of antioxidant mechanisms to help leukemia cells escape the damage caused by pro-oxidant drugs and develop drug resistance. Hematopoietic stem cells (HSCs) are extremely sensitive to oxidative stress due to their low levels of differentiation, and the use of pro-oxidant drugs inevitably causes damage to HSCs and may even cause severe bone marrow suppression. In this article, we reviewed research progress regarding the generation and regulation of ROS in normal HSCs and ALL cells as well as the impact of ROS on the biological behavior and fate of cells. An in-depth understanding of the regulatory mechanisms of redox homeostasis in normal and malignant HSCs is conducive to the formulation of rational targeted treatment plans to effectively reduce oxidative damage to normal HSCs while eradicating ALL cells.

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Oxidative Stress in Tunisian Patients With Acute Lymphoblastic Leukemia and Its Involvement in Leukemic Relapse

Cited by 15 publications

References 31 publications

Relationship of oxidative stress in the resistance to imatinib in Tunisian patients with chronic myeloid leukemia: A retrospective study

Relationship of oxidative stress in the resistance to imatinib in Tunisian patients with chronic myeloid leukemia: A retrospective study

Role of Sulforaphane on Histone Deacetylase Activity in Solid Ehrlich Carcinoma

Redox Control in Acute Lymphoblastic Leukemia: From Physiology to Pathology and Therapeutic Opportunities

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