Oxidative Stress in Vivax Malaria

Bilgin, Ramazan; Yalçın, M. Serkan; Yücebilgiç, Güzide; Koltas, Ismail Soner; Yazar, Süleyman

doi:10.3347/kjp.2012.50.4.375

Cited by 31 publications

(36 citation statements)

References 17 publications

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“…The mean erythrocyte concentration of SOD was significantly lower in patients than healthy subjects. Several studies reported reduction of SOD activities of erythrocytes in patients with malaria [15][16][17][18], which confirms results obtained. This affirms its role as an antioxidant, where levels decreased in an effort to offset the oxidant stress.…”

Section: Discussionsupporting

confidence: 81%

Changes in Levels of Antioxidant Markers and Status of Some Enzyme Activities among FalciparumMalaria Patients in Yemen

Ezzi

Salahy

Shnawa

et al. 2017

JMEN

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Clinical data indicate that oxidative stress and activities may play important roles in Plasmodium falciparum. The aim of this study was to assess the erythrocyte antioxidants and evaluate enzyme activities as marker for Plasmodium falciparum malaria patients. The diagnosis of malaria was confirmed by thick and thin film with Giemsa staining of malaria parasite. Ninety consenting individuals, sixty infected patients and thirty uninfected subjects comprising both sexes were randomly selected and age range between 18 to 48 years. The levels of Erythrocytic superoxide dismutase eSOD, serum ceruloplasmin (CP), vitamin C, alkaline phosphatase (ALP) and lactate dehydrogenase (LDH) were determined. Low levels of essential antioxidants such as eSOD and vitamin C in the patients have been found to be associated with an increased risk of Plasmodium falciparum malaria. Low levels of antioxidants observed in the falciparum malaria patients may be due to their increased utilization to free radical scavenger. High level of CP observed in the Plasmodium falciparum malaria patients may be of powerful potency against oxidative stress. Furthermore, lowered levels of antioxidants especially of vitamin C in malaria infection suggest that antioxidant may play a major role in the treatment of malaria infection. It was detected that serum levels of ALP and LDH were significantly higher in Plasmodium falciparum malaria patients group, compared with the healthy group. Higher levels of LDH and ALP in the Plasmodium falciparum malaria patients may be used in the diagnosis and treatment and monitoring of patients with malaria. Results also suggest that the rise in LDH activity may be as a result of the cellular anoxia of liver rather than other tissues in malaria patients.

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Section: Discussionsupporting

confidence: 81%

Changes in Levels of Antioxidant Markers and Status of Some Enzyme Activities among FalciparumMalaria Patients in Yemen

Ezzi

Salahy

Shnawa

et al. 2017

JMEN

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“…This was more common in P. vivax and mixed infection than P. falciparum infection. Our findings regarding the reduction in SOD level with that of severity of malarial infection is in correlation with the studies done by Erel et al, Bilgin et al and Narsaria et al 12,24,25 The SOD levels though not specific for malaria, along with positive parasite identification could be a sensitive indicator for severity of malaria infection.…”

Section: Discussionsupporting

confidence: 92%

“…12 Bilgin et al in their study found the activities superoxide dismutase and glutathione peroxidase were found to be significantly lower in vivax malaria patients. 24 Narsaria et al also found that there is significant elevation of malondialdehyde and protein carbonyl levels reflect the increased oxidative stress, whereas decreased levels of glutathione and superoxide dismutase point toward utilization of the antioxidants in severe malaria. 25 Thus, these changes in oxidants and antioxidants suggests the production of reactive oxygen species and their possible role in pathogenesis of severe malaria.…”

Section: Discussionmentioning

confidence: 97%

Platelet count and Superoxide Dismutase as a marker for severity of Plasmodium infection.

2017

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Background: Malaria continues to be an important public health problem in developing and underdeveloped countries with high morbidity and mortality. It continues to be one of the major public health problems in India. Plasmodium vivax is the major parasite type causing malaria and Plasmodium falciparum is the major cause of serious and complicated disease. Haematological abnormality which is most commonly seen in malaria is thrombocytopenia followed by anaemia. Identification of predictors of disease severity is critical to improve patient care. This study was undertaken to evaluate the severity of thrombocytopenia and erythrocyte SOD level in infections by plasmodium vivax, falciparum and mixed infection.Methods: A hospital based cross sectional study done on confirmed cases of malaria in a tertiary care hospital in costal Karnataka. All patients tested positive for malaria (either by rapid diagnostic test or peripheral smear) were included and patients presenting with fever who were but treated empirically for malaria were excluded in the study. The type of malarial infection was diagnosed with QBC and thin peripheral smear method; platelet count was done by automated cell counter and estimation of superoxide dismutase (SOD) by nitro blue tetrazolium chloride reduction method.Results: A total of forty infected malaria patients were evaluated. The age range of the infective patients were between 15 to 70 years. Males were more commonly affected than females in the ratio of 5.6:1. The most common type of malaria infection was from P. vivax and mixed infection (40% each) followed by P. falciparum (20%). Majority (50%) of the patient had severe infection followed by mild infection (35%) and moderate infection. The mean platelet count was 1,14,250/cu mm in P.falciparum, 85,000/cu mm in P.vivax infection and 60,625/cu mm in mixed infection. The mean platelet count was least (56,181/cu mm) in severe infective patients than in moderate (91,666/cu mm) and mild (1,21,500/cu mm) infections. The SOD levels was reduced more in P. vivax (26.43U/mg Hb) and mixed infection (20.96U/mg Hb) than P.falciparum (32.74U/mg Hb). SOD levels were proportionally low in severe infection (14.94U/mg Hb), when compared to moderate (20.35 U/mg Hb) and mild infection (32.19 U/mg Hb).Conclusions: Anaemia and thrombocytopenia are the most frequent haematological complications associated malaria. Thrombocytopenia is associated with increase in parasite density and severity of the infection, its more common in P.vivax and mixed infection than P.falciparum infection. The SOD level substantially reduces depending on the severity of malaria. Thrombocytopenia and reduced SOD level is a powerful predictor of disease severity. These parameters could be useful in the clinical approach of patients with malaria for prompt timely initiation of anti-malarial therapy and reduce the mortality.

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“…Es característico en la parasitemia por Plasmodium la actividad muy dinámica de las enzimas oxidantes y antioxidantes [18][19][20] . En esta infección se disminuyen las enzimas con función anti-oxidante (catalasas, superóxido dismutasas, glutation peroxidasas) pudiendo generar especies reactivas del oxígeno y que los fármacos antimaláricos (cloroquina y primaquina) aumentan la producción de ERO en linfocitos y macrófagos para la destrucción del microorganismo 1 .…”

Section: Discussionunclassified

Evaluación del efecto genotóxico en pacientes con malaria de una región de Colombia

Cuesta

Martínez

Massaro

et al. 2014

Rev. chil. infectol.

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Oxidative Stress in Vivax Malaria

Cited by 31 publications

References 17 publications

Changes in Levels of Antioxidant Markers and Status of Some Enzyme Activities among FalciparumMalaria Patients in Yemen

Changes in Levels of Antioxidant Markers and Status of Some Enzyme Activities among FalciparumMalaria Patients in Yemen

Platelet count and Superoxide Dismutase as a marker for severity of Plasmodium infection.

Evaluación del efecto genotóxico en pacientes con malaria de una región de Colombia

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