Oxidative stress in women with perimenopausal symptoms

Abstract

Objective: In this study, we examined the relationships between perimenopausal symptoms, biochemical parameters, and markers of oxidative stress in women in perimenopause and compared them with those of premenopausal women.Methods: Sixty-two women (age, 53.2 T 5.7 y) with perimenopausal symptoms were recruited to participate in our study. The control group consisted of 18 women without perimenopausal symptoms (age, 40 T 5 y).Clinical perimenopausal symptoms were evaluated via the questionnaire of the Menopausal Rating Scale. Our participants were checked for basic biochemical parameters. The oxidative status of our samples was determined through the examination of lipoperoxides, 8-oxoguanine (8-oxoG) levels, and the total antioxidant status (TAS).Results: Perimenopausal women had higher total cholesterol values and lower paraoxonase-1 (PON1) activity compared to reference values. Other biochemical parameters as well as 8-oxoG levels were unchanged compared with those of healthy control women. Lipoperoxide levels were significantly increased compared with those of premenopausal women. We found an indirect correlation between PON1 arylesterase (PON1 A) activity and lipoperoxide levels, between PON1 A activity and atherogenic index, between age and TAS, and between age and 8-oxoG levels. DNA repair ability and the total antioxidant status of women in perimenopause were significantly increased compared with women in premenopause. Hypercholesterolemic women had significantly increased lowdensity lipoprotein cholesterol levels when compared with normocholesterolemic individuals, but these values were still within the reference range. Normocholesterolemic women had significantly decreased high-density lipoprotein cholesterol levels, below the reference range. We found no correlations between perimenopausal symptoms and biochemical parameters or oxidative stress markers.Conclusions: We found that women in perimenopause are under increased oxidative stress manifested by reduced PON1 A activity and elevated lipoperoxidation, DNA repair ability, and TAS. Nutritional antioxidant supplementation may be an effective approach in improving menopausal symptoms.

Association of oxidative stress biomarkers with adiposity and clinical staging in women with breast cancer

“…Regarding the negative role of oxidative stress in the development of cancer, previous studies have shown that obesity in post-menopausal women can accelerate the reactive oxygen species generation. 14,30,31 Our results confirmed that higher values of 8-OHdG were observed in women with a large WC, whereas lower levels of retinol were correlated with an overweight status. 8-OHdG has been widely used as a biomarker of oxidative stress, and breast cancer has been considered to be a prognostic factor because a more aggressive tumour profile was associated with 8-OHdG serum levels and expression.…”

Inter-relações entre índice -3, estresse oxidativo e composição corporal em mulheres com câncer de mama

“…Regarding the negative role of oxidative stress in the development of cancer, previous studies have shown that obesity in postmenopausal women can accelerate ROS generation (12,26,27). Our results confirmed that higher values of 8-OHdG were observed in women with a large waist circumference, while lower levels of retinol were correlated with overweight.…”

Effect of Cruciferous Vegetable Intake on Oxidative Stress Biomarkers: Differences by Breast Cancer Status

“…Djuric and colleagues found significant differences by gender using a marker of oxidative damage (5-hydroxymethyl-2′-deoxyuridine [5-OHmdU] in DNA from nucleated blood cells) in a small isoflavone supplementation study ( n = 12) (25). It took longer to observe a decrease inoxidative damage in men (>3 weeks) than in women (~1 week) possibly due to including premenopausal women who may exhibit lower levels of reactive oxygen species due to significant variability by phase of the menstrual cycle (48, 49) and because the small level of supplementation (50 mg) was not enough to impact the typically higher weight of men. However, no difference was observed using isoprostane biomarkers (25).…”