Oxidative stress induced by corticosterone administration in broiler chickens (Gallus gallus domesticus)

Lin, Hai; Decuypere, Eddy; Buyse, Johan

doi:10.1016/j.cbpc.2004.09.013

Cited by 288 publications

(226 citation statements)

References 42 publications

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“…Likewise, decreased SOD activity is likely related to oxidative inactivation of enzymes by free radicals (Pigeolet et al 1990) due to reduced de novo synthesis (Kaushik and Kaur 2003). Despite possible redox imbalance, no cellular damage in cell membranes was observed, as indicated by a lack of differences among treatments in TBARS (Lin et al 2004). In addition, salinity affected the leukocyte profile, causing increased proportions of lymphocytes and granulocytes (table 1).…”

Section: Discussionmentioning

confidence: 99%

Physiological Stress Responses in Amphibian Larvae to Multiple Stressors Reveal Marked Anthropogenic Effects even below Lethal Levels

Burraco

Gómez-Mestre

2016

Physiological and Biochemical Zoology

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Natural and anthropogenic disturbances cause profound alterations in organisms, inducing physiological adjustments to avoid, reduce, or remedy the impact of disturbances. In vertebrates, the stress response is regulated via neuroendocrine pathways, including the hypothalamic-pituitary-interrenal axis that regulates the secretion of glucocorticoids. Glucocorticoids have cascading effects on multiple physiological pathways, affecting the metabolic rate, reactive oxygen species production, or immune system. Determining the extent to which natural and anthropogenic environmental factors induce stress responses in vertebrates is of great importance in ecology and conservation biology. Here we study the physiological stress response in spadefoot toad tadpoles (Pelobates cultripes) against three levels of a series of natural and anthropogenic stressors common to many aquatic systems: salinity (0, 6, and 9 ppt), herbicide (0, 1, and 2 mg/L acid equivalent of glyphosate), water acidity (pH 4.5, 7.0, and 9.5), predators (absent, native, and invasive), and temperature (217, 257, and 297C). The physiological stress response was assessed examining corticosterone levels, standard metabolic rate, activity of antioxidant enzymes, oxidative cellular damage in lipids, and immunological status. We found that common stressors substantially altered the physiological state of tadpoles. In particular, salinity and herbicides cause dramatic physiological changes in tadpoles. Moreover, tadpoles reduced corticosterone levels in the presence of natural predators but did not do so against invasive predators, indicating a lack of innate recognition. Corticosterone and the antioxidant enzyme glutathione reductase were the most sensitive parameters to stress in this study. Anthropogenic perturbations of aquatic systems pose serious threats to larval amphibians even at nonlethal concentrations, judging from the marked physiological stress responses generated, and reveal the importance of incorporating physiological information onto conservation, ecological, and evolutionary studies.

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Section: Discussionmentioning

confidence: 99%

Physiological Stress Responses in Amphibian Larvae to Multiple Stressors Reveal Marked Anthropogenic Effects even below Lethal Levels

Burraco

Gómez-Mestre

2016

Physiological and Biochemical Zoology

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“…In greenfinches (Carduelis chloris), the induction of an inflammatory response that produced free radicals (i.e., Bertrand et al 2006) promoted a rise in plasma TAS (Hõrak et al 2007). In domestic chickens (Gallus gallus domesticus), corticoid-induced stress increased plasma lipid peroxidation (Lin et al 2004a(Lin et al , 2004b as well as TAS and uric acid levels (Lin et al 2004a(Lin et al , 2004bMaurice et al 2007). Here, a similar adaptive response could have developed but as a result of oxidative challenges derived from aging.…”

Section: Discussionmentioning

confidence: 99%

Age and Breeding Effort as Sources of Individual Variability in Oxidative Stress Markers in a Bird Species

Alonso‐Álvarez

Pérez‐Rodríguez

García

et al. 2010

Physiological and Biochemical Zoology

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Oxidative stress is the imbalance between the production of pro-oxidant substances and the level of antioxidant defenses, which leads to oxidative damage. It has been proposed that senescence is the result of accumulated oxidative damage throughout life. In birds, the sources of individual variability in oxidative stress are still poorly understood. Among these sources, age, as related to senescence, should be particularly relevant. Furthermore, recent findings suggest that breeding effort may also deeply influence susceptibility to oxidative stress. However, there is still no evidence of a link between breeding effort and oxidative damage in any vertebrate. Here we analyzed 288 captive red-legged partridges (Alectoris rufa) across a wide age range (i.e., 1-8 yr old), thus including potentially senescent birds. In spite of limitations due to the crosssectional approach, results revealed that old birds produced less offspring and endured higher levels of oxidized glutathione and peroxidized lipids in erythrocytes than did middle-aged individuals. Old birds also showed higher plasma total antioxidant status and uric acid levels than did younger birds, but lower amounts of circulating carotenoids. Furthermore, hatching success was negatively correlated to lipid peroxidation in females but not in males, supporting the hypothesis that breeding effort promotes oxidative damage.

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“…For example, in broilers corticosterone administration caused decreases in serum SOD activity as well as in the apparent digestibility of energy, relative weight of bursa and thymus, total antioxidant capacity, and antibody titers to Newcastle disease virus [133]. In contrast, there was an increase in SOD activity in the chicken heart during short-term corticosterone administration [134]. In growing chickens exposed to high ammonia and low humidity blood antioxidative capacities and pectoral muscle SOD and GSH-Px activities were significantly reduced [135].…”

Section: Other Environmental Stressesmentioning

confidence: 97%

Antioxidant Systems in Poultry Biology: Superoxide Dismutase

Surai¹

2016

J Anim Res Nutr

168

135

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Commercial poultry production is associated with various stresses responsible for decreasing productive and reproductive performance of growing chicks, breeders and commercial layers. A growing body of evidence shows that most of stresses in poultry production at the cellular level are associated with oxidative stress. Recently, a concept of the cellular antioxidant defense has been revised with special attention paid to cellular redox status maintenance and cell signaling. In fact, antioxidant systems of the living cell are based on three major levels of defense and superoxide dismutase (SOD) is shown to belong to the first level of the antioxidant defense network. Cellular antioxidant defenses are shown to include several options and vitagene activation in stress conditions is considered as a fundamental adaptive mechanism. The vitagene family includes various genes regulating synthesis of protective molecules including thioredoxins, sirtuins, heat shock proteins and SOD. However, by the time of writing no comprehensive review on the roles and effects of SOD in poultry biology has appeared. Therefore, the aim of this review is a critical analysis of the role of SOD in poultry biology with specific emphasis to its functions as an essential part of the vitagene network. From the analysis of the recent data related to SOD in poultry physiology and adaptation to stresses it is possible to conclude that: a) SOD as important vitagene is the main driving force in cell/body adaptation to various stress conditions. Indeed, in stress conditions additional synthesis of SOD is an adaptive mechanism to decrease ROS formation; b) If the stress is too high SOD activity is decreased and apoptosis is activated; c) there are tissue-specific differences in SOD expression which also depends on the strength of such stress-factors as heat, heavy metals, mycotoxins and other stressors; d) SOD is shown to provide an effective protection against lipid peroxidation in chicken embryonic tissues and semen; e) SOD is shown to be protective in heat and cold stress, toxicity stress as well as in other oxidative-stress related conditions in poultry production; f) there are complex interactions inside the antioxidant network of the cell/body to ensure an effective maintenance of homeostasis in stress conditions. Indeed, in many cases, nutritional antioxidants (vitamin E, selenium, carotenoids, phytochemicals, etc.) in the feed can increase SOD expression; g) nutritional means of SOD upregulation in stress conditions of poultry production and physiological and commercial consequences await further investigation; h) vitagene upregulation in stress conditions is emerging as an effective means for stress management.

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Oxidative stress induced by corticosterone administration in broiler chickens (Gallus gallus domesticus)

Cited by 288 publications

References 42 publications

Physiological Stress Responses in Amphibian Larvae to Multiple Stressors Reveal Marked Anthropogenic Effects even below Lethal Levels

Physiological Stress Responses in Amphibian Larvae to Multiple Stressors Reveal Marked Anthropogenic Effects even below Lethal Levels

Age and Breeding Effort as Sources of Individual Variability in Oxidative Stress Markers in a Bird Species

Antioxidant Systems in Poultry Biology: Superoxide Dismutase

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