Oxidative Stress Induced by the 2,4-Dichlorophenoxyacetic Herbicide

Tayeb, Wafa; Nakbi, Amel; Chaieb, Ikbal; Hammami, Mohamed

doi:10.5772/33393

Cited by 3 publications

(3 citation statements)

References 62 publications

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“…Production of ROS can also be stimulated by phenoxy herbicides perhaps due to ROS formation by autoxidation, or a direct attack of the phenoxyl radicals on sensitive enzymes from a number of metabolic pathways (Selassie et al, 1998[ 153 ]). Indeed, several studies demonstrated that 2,4-D induced oxidative stress and depleted antioxidants both in vitro and in vivo (Bukowska, 2003[ 20 ]; Kubrak et al, 2013[ 94 ]; Matviishyn et al, 2014[ 118 ]; Wafa et al, 2012[ 184 ]).…”

Section: Principal Molecular Mechanisms Of Pesticide Toxicitymentioning

confidence: 99%

Pesticide toxicity: a mechanistic approach

Lushchak

Matviishyn

Husak

et al. 2018

EXCLI Journal; 17:Doc1101; ISSN 1611-2156

163

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Section: Principal Molecular Mechanisms Of Pesticide Toxicitymentioning

confidence: 99%

Pesticide toxicity: a mechanistic approach

Lushchak

Matviishyn

Husak

et al. 2018

EXCLI Journal; 17:Doc1101; ISSN 1611-2156

163

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“…Herbicides used in agriculture have known negative side effects in nontarget organisms. In particular, 2,4-dichlorophenyoxyacetic acid (2,4-D) is one of the most successfully and widely used herbicides worldwide in forestry and agriculture [1][2][3][4], despite being classified as possibly carcinogenic for humans [5] and having impacts on wildlife. It disrupts cell membranes and causes oxidative stress in nontarget organisms such as yeast, fish, amphibians, birds, rats, and humans, where it can be an oxidant and an endocrine disruptor, as well as being neurotoxic, immunosuppressive, and hepatotoxic [1,6,7].…”

Section: Introductionmentioning

confidence: 99%

“…In particular, 2,4‐dichlorophenyoxyacetic acid (2,4‐D) is one of the most successfully and widely used herbicides worldwide in forestry and agriculture , despite being classified as possibly carcinogenic for humans and having impacts on wildlife. It disrupts cell membranes and causes oxidative stress in nontarget organisms such as yeast, fish, amphibians, birds, rats, and humans, where it can be an oxidant and an endocrine disruptor, as well as being neurotoxic, immunosuppressive, and hepatotoxic . The effects of 2,4‐D are poorly known in invertebrates, but it influences sex ratio and gene expression of heat shock proteins in exposed dipterans , reduces body size and increases oxidative stress in earthworms , accelerates adult emergence in caterpillars , and has suspected effects on reproductive function and community composition of dung beetles .…”

Section: Introductionmentioning

confidence: 99%

Effects of an herbicide on physiology, morphology, and fitness of the dung beetle Euoniticellus intermedius (Coleoptera: Scarabaeidae)

González‐Tokman

Martínez-Morales

Farrera

et al. 2016

Enviro Toxic and Chemistry

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Some agrochemical compounds threaten nontarget organisms and their functions in the ecosystem. The authors experimentally evaluated the effects of one of the most common herbicide mixtures used worldwide, containing 2,4-dichlorophenoxyacetic acid and picloram, on dung beetles, which play fundamental roles in the function of natural and managed ecosystems. The present study employed techniques of physiology and geometric morphometrics, besides including fitness measurements, to assess the effects of the herbicide in the introduced beetle Euoniticellus intermedius. Because herbicide components promote oxidative stress and affect survival in certain insects, the authors predicted negative effects on the beetles. Unexpectedly, no effect of herbicide concentration was found on clutch size, sex ratio, and fluctuating asymmetry, and it even increased physiological condition and body size in exposed beetles. Because the studied species presents 2 male morphs, the authors, for the first time, evaluated the effect of a pollutant on the ratio of these morphs. Contrary to the prediction, the herbicide mixture increased the proportion of major males. Thus, the herbicide does not threaten populations of the studied beetles. The present study discusses how both negative and positive effects of pollutants on wild animals modify natural and sexual selection processes occurring in nature, which ultimately impact population dynamics. The authors recommend the use of physiological and geometric morphometrics techniques to assess the impact of pollutants on nontarget animals. Environ Toxicol Chem 2017;36:96-102. © 2016 SETAC.

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2,4-Dichlorphenoxicacetic Acid at Low Concentrations Enhances Reproductive Ability and Oxidative Stress Resistance of Yeast Saccharomyces Cerevisiae

Bayliak

Burdylyuk

2015

jpnu

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2,4-dichlorphenoxicacetic acid (2,4-D) is one of the most widely used herbicides withwell documented toxic effects on non-target organisms. In this study, the effect of lowconcentrations of 2,4-D on reproductive activity and resistance of yeast S. cerevisiae to oxidativestress was evaluated. Supplementation of the cultivation medium with 0.1-100 µM 2,4-D did notaffect the rate of yeast growth. In early stationary phase, yeast cultures grown with 0.1 and 1 µM2,4-D had higher number of reproductively active cells than control ones (without 2,4-D). Inexponential phase, S. cerevisiae cells grown in the presence of 1-100 µM 2,4-D were more resistantto hydrogen peroxide comparing to control ones. Thus, the herbicide increased reproductivepotential and cross-resistance to oxidative stress in yeast but the effective concentrations of 2,4-Dwere different for these phenomena. In summary, the results suggest possible involvement ofcertain hormetic mechanisms in the influence of 2,4-D at low concentrations on yeast

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Oxidative Stress Induced by the 2,4-Dichlorophenoxyacetic Herbicide

Cited by 3 publications

References 62 publications

Pesticide toxicity: a mechanistic approach

Pesticide toxicity: a mechanistic approach

Effects of an herbicide on physiology, morphology, and fitness of the dung beetle Euoniticellus intermedius (Coleoptera: Scarabaeidae)

2,4-Dichlorphenoxicacetic Acid at Low Concentrations Enhances Reproductive Ability and Oxidative Stress Resistance of Yeast Saccharomyces Cerevisiae

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