Oxidative stress-induced cognitive impairment in obesity can be reversed by vitamin D administration in rats

Hajiluian, Ghazaleh; Farhangi, Mahdieh Abbasalizad; Nameni, Ghazaleh; Shahabi, Parviz; Megari-Abbasi, Mehran

doi:10.1080/1028415x.2017.1348436

Cited by 54 publications

(37 citation statements)

References 43 publications

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“…Indeed, it has been reported that obese rats treated with VD supplementation showed a reduced inflammatory biomarkers in the hippocampus. [ 11 ] Moreover, VD supplementation has also shown a significant improvement in the cognitive performance in elderly patients with senile dementia. [ 12 ] VD deficiency affects the endocrinal function as it leads to increasing insulin resistance and an alteration in pancreatic β-cell function.…”

Section: Introductionmentioning

confidence: 99%

Vitamin D deficiency in elderly: Risk factors and drugs impact on vitamin D status

Kweder¹,

Eidi

2018

Avicenna J Med

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Introduction:Vitamin D (VD) deficiency is a major public health problem worldwide. In spite of its high prevalence, particularly among elderly people, VD deficiency is still underestimated by many physicians. Increasingly, VD deficiency is associated with several known geriatric syndromes.Methods:The study sample consisted of 125 patients, aged 75 years and older, admitted to the acute geriatric unit. The plausible association between the serum 25-hydroxyvitamin D [25(OH)D] level and patient age, sex, body mass index, renal function, cholecystectomy history, and the prescribed drugs had been investigated. The Fisher's exact test was used to conduct the statistical analysis of data.Results:Surprisingly, furosemide treatment was correlated with normal 25(OH)D levels and an increased incidence of secondary hyperparathyroidism. Unlike the other four parameters mentioned above, our data showed that only the patient sex exhibited a significant association with 25(OH)D level as elderly males suffered from a serious VD deficiency as compared to elderly females.Conclusion:Old age is an independent risk factor for VD deficiency. The supplementary dose of VD should be precisely defined to achieve the optimal serum 25(OH)D level in elderly people. The definition of the normal serum 25(OH)D threshold in elderly furosemide-treated patients is worth of further studies.

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Section: Introductionmentioning

confidence: 99%

Vitamin D deficiency in elderly: Risk factors and drugs impact on vitamin D status

Kweder¹,

Eidi

2018

Avicenna J Med

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“…; Hajiluian et al . ). Interestingly, previous data indicating that HFD‐induced behavioral changes and hippocampal dysfunction as a consequence of increased oxidative stress were obtained in the NNT‐deficient C57Bl/6J mice (Arnold et al .…”

Section: Discussionmentioning

confidence: 97%

“…HFDs are known to induce metabolic derangements that are accompanied by systemic inflammation, oxidative imbalance (Furukawa et al 2004;Studzinski et al 2009), cognitive decline, and behavioral alterations (Tucsek et al 2014;Cordner and Tamashiro 2015). Some of these alterations can be prevented by antioxidant administration (Alzoubi et al 2013(Alzoubi et al , 2018Chang et al 2014;Liu et al 2014;Hajiluian et al 2017). Interestingly, previous data indicating that HFD-induced behavioral changes and hippocampal dysfunction as a consequence of increased oxidative stress were obtained in the NNT-deficient C57Bl/6J mice (Arnold et al 2014;Krishna et al 2015).…”

Section: Discussionmentioning

confidence: 98%

Nicotinamide nucleotide transhydrogenase is required for brain mitochondrial redox balance under hampered energy substrate metabolism and high‐fat diet

Francisco

Ronchi

Navarro

et al. 2018

Journal of Neurochemistry

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Among mitochondrial NADP‐reducing enzymes, nicotinamide nucleotide transhydrogenase (NNT) establishes an elevated matrix NADPH/NADP+ by catalyzing the reduction of NADP+ at the expense of NADH oxidation coupled to inward proton translocation across the inner mitochondrial membrane. Here, we characterize NNT activity and mitochondrial redox balance in the brain using a congenic mouse model carrying the mutated Nnt gene from the C57BL/6J strain. The absence of NNT activity resulted in lower total NADPH sources activity in the brain mitochondria of young mice, an effect that was partially compensated in aged mice. Nonsynaptic mitochondria showed higher NNT activity than synaptic mitochondria. In the absence of NNT, an increased release of H2O2 from mitochondria was observed when the metabolism of respiratory substrates occurred with restricted flux through relevant mitochondrial NADPH sources or when respiratory complex I was inhibited. In accordance, mitochondria from Nnt‐/‐ brains were unable to sustain NADP in its reduced state when energized in the absence of carbon substrates, an effect aggravated after H2O2 bolus metabolism. These data indicate that the lack of NNT in brain mitochondria impairs peroxide detoxification, but peroxide detoxification can be partially counterbalanced by concurrent NADPH sources depending on substrate availability. Notably, only brain mitochondria from Nnt−/− mice chronically fed a high‐fat diet exhibited lower activity of the redox‐sensitive aconitase, suggesting that brain mitochondrial redox balance requires NNT under the metabolic stress of a high‐fat diet. Overall, the role of NNT in the brain mitochondria redox balance especially comes into play under mitochondrial respiratory defects or high‐fat diet.

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“…Vitamin D is thought to have antioxidant properties although involved mechanisms have not been fully described yet and further research is required [18,170]. Vitamin D, acting through its nuclear receptors, can stimulate the expression of genes coding for antioxidant enzymes such as SODs and GPxs [171]. It has also been confirmed that after exposure of the skin to UV radiation, calcitriol and its precursors increase p53 levels, which reduces intracellular ROS [172].…”

Section: Vitamin D-function and Antioxidant Effectmentioning

confidence: 99%

Ionizing Radiation as a Source of Oxidative Stress—The Protective Role of Melatonin and Vitamin D

Nuszkiewicz

Woźniak

Szewczyk-Golec

2020

IJMS

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Ionizing radiation (IR) has found widespread application in modern medicine, including medical imaging and radiotherapy. As a result, both patients and healthcare professionals are exposed to various IR doses. To minimize the negative side effects of radiation associated with oxidative imbalance, antioxidant therapy has been considered. In this review, studies on the effects of melatonin and vitamin D on radiation-induced oxidative stress are discussed. According to the research data, both substances meet the conditions for use as agents that protect humans against IR-induced tissue damage. Numerous studies have confirmed that melatonin, a hydro- and lipophilic hormone with strong antioxidant properties, can potentially be used as a radioprotectant in humans. Less is known about the radioprotective effects of vitamin D, but the results to date have been promising. Deficiencies in melatonin and vitamin D are common in modern societies and may contribute to the severity of adverse side effects of medical IR exposure. Hence, supporting supplementation with both substances seems to be of first importance. Interestingly, both melatonin and vitamin D have been found to selectively radiosensitise cancer cells, which makes them promising adjuvants in radiotherapy. More research is needed in this area, especially in humans.

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Oxidative stress-induced cognitive impairment in obesity can be reversed by vitamin D administration in rats

Abstract: Vitamin D improved hippocampus oxidative stress and inflammatory markers in HFD-induced obese rats and improved cognitive performance. Further studies are needed to better clarify the underlying mechanisms.

Cited by 54 publications

References 43 publications

Vitamin D deficiency in elderly: Risk factors and drugs impact on vitamin D status

Vitamin D deficiency in elderly: Risk factors and drugs impact on vitamin D status

Nicotinamide nucleotide transhydrogenase is required for brain mitochondrial redox balance under hampered energy substrate metabolism and high‐fat diet

Ionizing Radiation as a Source of Oxidative Stress—The Protective Role of Melatonin and Vitamin D

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