2024
DOI: 10.1002/jev2.12468
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Oxidative stress induces extracellular vesicle release by upregulation of HEXB to facilitate tumour growth in experimental hepatocellular carcinoma

Jiufei Duan,
Zhao Huang,
Siyuan Qin
et al.

Abstract: Extracellular vesicles (EVs) play a crucial role in triggering tumour‐aggressive behaviours. However, the energetic process by which tumour cells produce EVs remains poorly understood. Here, we demonstrate the involvement of β‐hexosaminidase B (HEXB) in mediating EV release in response to oxidative stress, thereby promoting the development of hepatocellular carcinoma (HCC). Mechanistically, reactive oxygen species (ROS) stimulate the nuclear translocation of transcription factor EB (TFEB), leading to the upreg… Show more

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